Evolving Societal Risks and Necessary Precautions in the Age of Nuclear Power and Therapeutic Radiation: An American Perspective

Pham, Martin H.; Yu, Cheng; Rusch, Mairead; Holloway, Catherine; Chang, Eric L.; Apuzzo, Michael L.J.

doi:10.1016/j.wneu.2014.09.007

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…After decades of research, very few treatment options exist to combat the effects of whole-body irradiation [ 11 , 17 ]. With the growing risk of mass exposure to life-threatening doses of IR, there is an urgent need to develop effective, nontoxic medical countermeasures [ 6 , 8 , 26 ]. A variety of synthetic compounds, as well as those derived from natural sources, have been tested for their radioprotective potential in vitro as well as in vivo .…”

Section: Discussionmentioning

confidence: 99%

“…Currently, radiation therapy of cancers is the main contributor to radiation injury [ 1 – 4 ]. However, with the growing use of nuclear energy sources and the development of nuclear weapons by nations worldwide, there is a growing risk of mass exposure of the general population to IR caused by nuclear reactor accidents or acts of nuclear terrorism [ 5 , 6 ]. Such incidents would demand immediate therapeutic intervention to prevent widespread morbidity and mortality caused by radiation injury [ 7 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

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MDP: A Deinococcus Mn2+-Decapeptide Complex Protects Mice from Ionizing Radiation

Gupta

Gayen

Smith³

et al. 2016

PLoS ONE

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The radioprotective capacity of a rationally-designed Mn2+-decapeptide complex (MDP), based on Mn antioxidants in the bacterium Deinococcus radiodurans, was investigated in a mouse model of radiation injury. MDP was previously reported to be extraordinarily radioprotective of proteins in the setting of vaccine development. The peptide-component (DEHGTAVMLK) of MDP applied here was selected from a group of synthetic peptides screened in vitro for their ability to protect cultured human cells and purified enzymes from extreme damage caused by ionizing radiation (IR). We show that the peptides accumulated in Jurkat T-cells and protected them from 100 Gy. MDP preserved the activity of T4 DNA ligase exposed to 60,000 Gy. In vivo, MDP was nontoxic and protected B6D2F1/J (female) mice from acute radiation syndrome. All irradiated mice treated with MDP survived exposure to 9.5 Gy (LD70/30) in comparison to the untreated mice, which displayed 63% lethality after 30 days. Our results show that MDP provides early protection of white blood cells, and attenuates IR-induced damage to bone marrow and hematopoietic stem cells via G-CSF and GM-CSF modulation. Moreover, MDP mediated the immunomodulation of several cytokine concentrations in serum including G-CSF, GM-CSF, IL-3 and IL-10 during early recovery. Our results present the necessary prelude for future efforts towards clinical application of MDP as a promising IR countermeasure. Further investigation of MDP as a pre-exposure prophylactic and post-exposure therapeutic in radiotherapy and radiation emergencies is warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MDP: A Deinococcus Mn2+-Decapeptide Complex Protects Mice from Ionizing Radiation

Gupta

Gayen

Smith³

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

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“…There has been a growing number of incidents in recent years, and the possibility of radiological terrorism seems most alarming. [1][2][3][4][5][6] The multiplication effect-fear of terrorism and fear of radiation-makes the probability of committing acts of radiological terrorism very high. [7][8][9][10] The most probable scenario considered is the spread of radioactive material (dirty bomb) in the central part of a large city.…”

mentioning

confidence: 99%

Diagnostic Criteria for Assessment by General Practitioners of Patients Injured in Radiation Incidents and Cases of Radiological Terrorism

Zahariev

Hristov

2017

Disaster med. public health prep.

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The general practitioner is an important figure in the provision of medical care during radiation incidents and cases of radiological terrorism. Knowing the nature of the radiation injury is essential for correct diagnosis and treatment. Insufficient knowledge of most physicians, and of general practitioners in particular, on the clinical manifestation of radiation injuries is the reason such conditions remain unrecognized and improperly treated. We suggest some simple diagnostic criteria for assessment of the injured by general practitioners, based on the results of our own studies and on the recommendations of prominent international organizations. (Disaster Med Public Health Preparedness. 2018;12:507–512)

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Surface modification of petroleum residue-activated carbon using citric acid for enhanced cobalt removal from an aqueous solution

Choi

Jeon

Choi

2023

Korean J. Chem. Eng.

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Evolving Societal Risks and Necessary Precautions in the Age of Nuclear Power and Therapeutic Radiation: An American Perspective

Cited by 3 publications

References 10 publications

MDP: A Deinococcus Mn2+-Decapeptide Complex Protects Mice from Ionizing Radiation

MDP: A Deinococcus Mn2+-Decapeptide Complex Protects Mice from Ionizing Radiation

Diagnostic Criteria for Assessment by General Practitioners of Patients Injured in Radiation Incidents and Cases of Radiological Terrorism

Surface modification of petroleum residue-activated carbon using citric acid for enhanced cobalt removal from an aqueous solution

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