Ewing's Primary Cutaneous Sarcoma in a Pregnant Patient: A Case Report

Posada, Marielos; Villalta, Gabriela; Roldan, Maria-Sofia; Sarti, Helga M

doi:10.1016/j.adengl.2020.12.010

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Primary cutaneous tumours tend to be less aggressive than osseous ones, their growth is usually characterised by a single superficial mass, with a smaller tumour size. These characteristics provide easier identification and diagnosis through clinical examination, avoiding the further spread of the tumour and facilitating surgical resection 10 11. Fortunately, this case was detected early, and diagnostic and staging of the tumour were promptly done documenting the absence of metastatic involvement, and additionally pregnancy was near its term, allowing termination at 37 weeks to rapidly start the treatment of the tumour.…”

Section: Discussionmentioning

confidence: 91%

Malignant tumour in pregnancy: Ewing-like sarcoma of the gluteal region

Gouveia,

Xavier,

Silva

et al. 2024

BMJ Case Rep

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We report a case of an Ewing-like sarcoma of the gluteal region with ongoing growth during the second trimester of pregnancy and noted during the third trimester. This lesion was consequently studied to infer its malignant potential. Several examinations were conducted to characterise this lesion, such as ultrasound and MR, which showed signs of tumourous invasion of the deep tissues of the gluteal region.Given that the pregnancy was at the end of the third trimester, the decision was made to schedule the delivery at 37 weeks of gestation and treat the tumour afterwards to balance maternal and fetal health.This case illustrates the need for a detailed investigation and guidance by a multidisciplinary team to provide prenatal counselling regarding a malignant tumour during pregnancy.

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Section: Discussionmentioning

confidence: 91%

Malignant tumour in pregnancy: Ewing-like sarcoma of the gluteal region

Gouveia,

Xavier,

Silva

et al. 2024

BMJ Case Rep

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“…Overall, the prognosis is good, with favorable maternal and fetal outcomes, providing close clinical surveillance and multidisciplinary management during the prenatal and postnatal periods. [25][26][27] Additional larger longitudinal study sets of patients with this exceedingly rare tumor need to be evaluated to determine long-term prognosis and outcome in pregnancy. 3,22…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Ewing Sarcoma of the Scalp With Metastasis to the Lung: An Unusual Manifestation During Pregnancy

Regmi¹,

Raouf²,

Mudaliar³

et al. 2023

The American Journal of Dermatopathology

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:A 32-year-old G2P1L1 (5 months pregnant) woman presented with a 3-month history of a slow-growing cystic lesion on her scalp vertex. Similar lesions in the exact location were excised twice in the past with a diagnosis of trichilemmal carcinoma (TC). A biopsy of the scalp lesion showed morphology and immunoprofile consistent with previously diagnosed TC. Staging PET/CT demonstrated a 4.7 cm right upper lobe lung, and a subsequent lung biopsy showed a small, round blue-cell tumor with necrosis, morphologically identical to the prior biopsies from the scalp. Considering the unusual clinical course of TC, a lung biopsy was sent for next-generation sequencing that showed EWSR1-FLI1 (type1) fusion. Additionally, CD99 immunostaining revealed uniform cytoplasmic and membranous staining in the tumor cells. The previous scalp excision specimen was also sent for mutation analysis, which showed EWSR1-FLI1 fusion. In conjunction with clinical history and histological and molecular findings, a definitive diagnosis of primary cutaneous Ewing sarcoma (PCES) with local recurrence and metastasis to the lung was made. We present a case of PCES, which was previously misdiagnosed and treated as TC. This case emphasizes the importance of CD99 in the initial screening of cutaneous small round blue-cell tumors to avoid misdiagnosis from other morphological overlaps. Also, despite its rarity, PCES should be included in the differential diagnosis of small, round, blue cell tumors at cutaneous sites. Our case also exemplifies common biases in medical decision-making, including premature closure and anchoring bias which can result in misdiagnosis or diagnostic delay and associated delay in appropriate management.

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Ewing's Primary Cutaneous Sarcoma in a Pregnant Patient: A Case Report

Cited by 2 publications

References 8 publications

Malignant tumour in pregnancy: Ewing-like sarcoma of the gluteal region

Malignant tumour in pregnancy: Ewing-like sarcoma of the gluteal region

Primary Cutaneous Ewing Sarcoma of the Scalp With Metastasis to the Lung: An Unusual Manifestation During Pregnancy

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