Ewing's sarcoma of the pelvis

Capanna, Rodolfo; Toni, Aldo; Sudanese, A; McDonald, Douglas J.; Bacci, Gaetano; Campanacci, Mario

doi:10.1007/bf00183366

Cited by 25 publications

(6 citation statements)

References 14 publications

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“…In the European Intergroup Cooperative Study, eight of nine patients that developed a secondary malignancy had received radiation [10]. Radiation has often been reserved for more difficult to resect locations such as the pelvis [7, 14, 18–20]. Radiation has also been preferred for local treatment in the presence of metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies, in which up to 80–90% of patients received radiation therapy (XRT) for local control with or without surgery, have shown that XRT alone for local control is associated with poor outcomes [8, 12, 17]. Many patients received XRT for local control because metastatic disease and pelvic location were thought to preclude aggressive local treatment [7, 14, 18–20]. …”

Section: Introductionmentioning

confidence: 99%

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Should Aggressive Surgical Local Control Be Attempted in All Patients with Metastatic or Pelvic Ewing's Sarcoma?

Thorpe

Weiß

Goodman³

et al. 2012

Sarcoma

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In previous reports, patients with Ewing's sarcoma received radiation therapy (XRT) for definitive local control because metastatic disease and pelvic location were thought to preclude aggressive local treatment. We sought to determine if single-site metastatic disease should be treated differently from multicentric-metastatic disease. We also wanted to reinvestigate the impact of XRT, pelvic location, and local recurrence on outcomes. Our results demonstrated a significant difference in overall survival (OS) between patients with either localized disease or a single-metastatic site and patients with multicentric-metastatic disease (P = 0.004). Local control was also found to be an independent predictor of outcomes as demonstrated by a significant difference in OS between those with and without local recurrence (P = 0.001). Axial and pelvic location did not predict a decreased OS. Based on these results, we concluded that pelvic location and the diagnosis of metastatic disease at diagnosis should not preclude aggressive local control, except in cases of multicentric-metastatic disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Should Aggressive Surgical Local Control Be Attempted in All Patients with Metastatic or Pelvic Ewing's Sarcoma?

Thorpe

Weiß

Goodman³

et al. 2012

Sarcoma

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“…Most regimens are a combination of these (ARAI et al 1991;BADER et al 1989;BURGERTet al 1990;CANGIR et al 1990;CAPANNA et al 1990;DUNST et al 1991;HAYES et al 1989;NESBIT et al 1990;OBERLIN et al 1985;SAILER et al 1988;WILKINS et al 1986). Most regimens are a combination of these (ARAI et al 1991;BADER et al 1989;BURGERTet al 1990;CANGIR et al 1990;CAPANNA et al 1990;DUNST et al 1991;HAYES et al 1989;NESBIT et al 1990;OBERLIN et al 1985;SAILER et al 1988;WILKINS et al 1986).…”

Section: Systemic Therapymentioning

confidence: 99%

Radiation Therapy in Pediatric Oncology

Cassady¹

1994

Medical Radiology

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The use of general descriptive names, registered, trademarks, etc. in this publications does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Typesetting: Thomson Press (India) Ltd., New Delhi SPIN: 1 0042321 21 13130/SPS -5 4 3 2 I 0 -printed on acid-free paper PrefaceThis book provides a thorough review of the role that radiation therapy currently plays in the management of most childhood tumors. Extensively augmented with figures and tables where appropriate, it also provides a concise review of current diagnostic and therapeutic approaches for major childhood malignancies. Extensive and up-to-date reference lists are an added benefit. Chapters on principles of pediatric radiation therapy, etiology of childhood tumors, and newer, molecular approaches in pediatric oncology are provided.Authors include leaders in the field writing on their particular areas of interest and expertise, providing a diversity of approach useful to the reader.Many people have been responsible for this book. Primary thanks must go to our many childhood patients and their parents who have allowed us the privilege of treating them. Appreciation and thanks are due to my many teachers and particular role models, HENRY

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“…Pelvic Ewing sarcoma (ES) accounts for roughly a quarter of all primary tumor sites with literature reports ranging between 15 and 35% [1][2][3][4][5][6][7][8][9]. Since 1970, the introduction of chemotherapy drastically improved the overall prognosis of ES but survival of pelvic primaries remained inferior to that of extremity locations [6,7,[10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Pelvic ES's infamous and dismal prognosis led to an increased effort of analyzing outcomes in treated patient cohorts since the 1990s. Some studies did not find differences in disease-free and overall survival by comparing operatively treated pelvic ES with or without radiation therapy with radiation therapy alone [8,10,12]. Meanwhile, other studies published improved local control and overall survival rates for patients who underwent pelvic tumor resection or combined local treatment [2,11,[25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Pelvic Ewing sarcoma: a retrospective outcome analysis of 104 patients who underwent pelvic tumor resection at a single supra-regional center

et al. 2020

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Background Local treatment in pelvic Ewing sarcoma (ES) consists of operation, radiation therapy, or a combination of both. Reported outcomes vary depending on the treatment modality performed. It is the objective of this study to analyze surgical outcome and complications as well as oncological outcome and complications of chemo- and radiation therapy in this patient cohort and evaluate prognostic factors. Methods Retrospective review of 104 patients who underwent tumor resection for pelvic ES from 1988 to 2014. Results All patients underwent pelvic resection and radiation therapy was administered in 77.9%. Margins were clear in 94.2%. The response to chemotherapy was good in 78.8%. Local recurrence occurred in 7.7%. The presence of distant metastases at the time of operation was the most important negative predictor for overall survival (p = 0.003). The cumulative 5- and 10-year survival rates were 82.7% and 80.1% for non-metastasized and 61.4% and 41.6% for metastasized pelvic ES at operation. In the presence of a single-distant metastatic site at operation compared to multiple metastatic sites, the cumulative survival rates were 64.3% versus 50% at five and 50.7% versus 16.7% at 10 years. Conclusions A combined treatment approach of tumor resection and radiation therapy leads to a local control and overall survival rates comparable with those of extremity locations in this study’s patient cohort with localized pelvic ES. Therefore, surgical tumor resection (combined with (neo-)adjuvant radiation therapy) in non-metastatic pelvic ES seems feasible. In metastatic patients, however, the significance of tumor resection as a part of local treatment remains less certain and improved outcomes of combined local treatment approaches need to be weighed against these patients’ prognosis and quality of life.

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Ewing's sarcoma of the pelvis

Cited by 25 publications

References 14 publications

Should Aggressive Surgical Local Control Be Attempted in All Patients with Metastatic or Pelvic Ewing's Sarcoma?

Should Aggressive Surgical Local Control Be Attempted in All Patients with Metastatic or Pelvic Ewing's Sarcoma?

Radiation Therapy in Pediatric Oncology

Pelvic Ewing sarcoma: a retrospective outcome analysis of 104 patients who underwent pelvic tumor resection at a single supra-regional center

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