Ewing's Sarcoma of the Talus in an Adolescent Female: An Unusual Case Presentation With Review of Literature

Abstract

Ewing's sarcoma is an aggressive primary malignant bone tumor that affects long and flat bones and is commonly seen in children and adolescents. The involvement of the foot especially the talus is an extremely rare entity with less than 15 cases reported in the literature. The rarity and atypical symptoms often lead to delays in diagnosis affecting the prognosis and survival. We present a 14-year-old female with pain and swelling of the left ankle for 18 months. She was being treated previously for an ankle sprain and was later suspected of avascular necrosis of the talus, before presenting to us. Clinicoradiology-pathological workup confirmed the diagnosis of Ewing sarcoma of the talus. Further, the metastatic workup revealed multiple skeletal metastases at the time of diagnosis. The metastatic lesion of the right femur required prophylactic fixation, otherwise, the patient was treated with palliative chemotherapy and radiotherapy. Ewing's sarcoma of the foot involving the talus is extremely rare and is a commonly misdiagnosed entity, affecting the overall prognosis of the patient. A high index of suspicion and a multidisciplinary approach is imperative for its early diagnosis and definitive management.

Expression of NKX2.2 in Non-Ewing Tumors With Round Cell Morphology

“…Ewing sarcoma is an aggressive neoplasm and most often occurs in children and young adults [ 1 ]. The diagnosis has proved difficult for clinicians and pathologists because it belongs to the category of “small round blue cell tumor.” Many other sarcomas are also identified under this umbrella, all of which have almost similar morphologic characteristics [ 2 ].…”

“…Ewing sarcoma is an aggressive neoplasm and most often occurs in children and young adults [1]. The diagnosis has proved difficult for clinicians and pathologists because it belongs to the category of "small round blue cell tumor."…”