Ewing sarcoma/primitive neuroectodermal tumor of the kidney in a child

“…Extraosseous (EO) ES is usually seen in the soft tissue of the lower extremities and the paravertebral region but has also been reported to arise in the gastrointestinal tract [10], kidney [11], uterus [12] and other infrequent sites [13, 14, 15]. …”

Section: Introductionmentioning

confidence: 99%

An Unusual Location of Extraosseous Ewing's Sarcoma

Geens¹,

Robays²,

Verswijvel

et al. 2013

Case Rep Oncol

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“…PNETs are derived from primitive neural crest cells and usually occur in bone or soft tissues of the extremities, trunk, head, and neck, and less commonly in the viscera or kidneys [5,6]. However, many cases of PNET of the kidney have been reported since the original description of this condition by Seemayer et al [3], with 14 cases reported in Japan [7][8][9][10][11][12][13]. The typical histological features of renal PNET are monotonous proliferation of immature and small round cells with at least partial formation of Homer-Wright-type or Flexner-type rosettes [1,14].…”

Section: Discussionmentioning

confidence: 98%

Primary Ewing’s sarcoma/primitive neuroectodermal tumor of the kidney that responded to low-dose chemotherapy with ifosfamide, etoposide, and doxorubicin

et al. 2010

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A primitive neuroectodermal tumor (PNET) is a small round cell tumor that arises from the nerve crest. This tumor usually occurs in the central nervous system or soft tissue, but it can occur in the kidney in rare cases. Herein we report a case with severe multiple liver metastases after surgery for right renal PNET. The patient was a 21-year-old man with a chief complaint of right abdominal pain. Hemorrhage in a right renal malignant tumor was diagnosed, and radical nephrectomy was performed. Histopathology showed bare nuclear round atypical cells with a scarce cytoplasm proliferating like a seat and nest. Some of the cells formed a rosette structure and the tumor cells were positive for CD99, leading to diagnosis of PNET. Severe multiple liver metastases occurred 6 months after surgery, and six courses of chemotherapy with ifosfamide, etoposide and doxorubicin were performed. After this treatment, residual tumor was removed, but the tumor cells were absent histologically.

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“…[6] EO ES is generally seen in the lower extremities and the paravertebral region. It has also been reported to arise in the gastrointestinal tract, [7] kidney, [8] uterus [9] and other infrequent sites. [10][11][12] Imaging is worthwhile for local spread, resectability and metastases.…”

Section: Discussionmentioning

confidence: 99%

Pictorial Review of Extraosseous Ewing’s Tumour: A Single Center Experience

Fayyaz

Niazi

Iqbal

2017

J Cancer Allied Spec

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Purpose: Ewing’s family tumour is an extremely rare tumour, with annual incidence rates amongst Caucasian children <21 years being in the range of 2–3 cases per million in the U.S. There are mainly three subtypes including Ewing’s sarcoma (ES) of bone, extraosseous (EO) Ewing’s tumour and Peripheral primitive neuroectodermal tumour. Although extremely rare, this study represents a review of various types of cases and the significance of imaging including its baseline and post-treatment response radiological characteristics. There are a very few cases of EO ES in the current literature with variable spectrum of tumour site and their imaging characteristics.Materials and Methods: Electronic records were retrospectively reviewed from 1 May 2011 to 1 May 2016 with patients who were diagnosed as histologically proven ES. A number of patients, gender and base line computed tomography (CT)/magnetic resonance imaging findings for staging were reviewed.Results: A total of 568 patients with diagnosed ES were analysed, of which 15 patients had EO type of ES. Of these only 8 patients had baseline imaging available which included tumours arising from the occipital region, orbit, anterior mediastinum, anterior abdominal wall, mesentery, kidney, prostate gland and presacral region.Conclusion: EO ES is a rare entity and can involve a wide array of soft tissue organs. A cross-sectional imaging with CT and MR has a key role in pre- and post-treatment assessment.Key words: Computed tomography, Ewing’s sarcoma, extraosseous Ewing’s, magnetic resonance imaging, peripheral primitive neuroectodermal tumour

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Ewing sarcoma/primitive neuroectodermal tumor of the kidney in a child

Cited by 14 publications

References 17 publications

An Unusual Location of Extraosseous Ewing's Sarcoma

An Unusual Location of Extraosseous Ewing's Sarcoma

Primary Ewing’s sarcoma/primitive neuroectodermal tumor of the kidney that responded to low-dose chemotherapy with ifosfamide, etoposide, and doxorubicin

Pictorial Review of Extraosseous Ewing’s Tumour: A Single Center Experience

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