Ex Vivo Administration of Human Mesenchymal Stem Cells Ameliorates Injury in Pig Lungs Through an Increase in Parenchymal VEGF and a Decrease in Circulating IL-8

Mordant, Pierre; Nakajima, Daisuke; Kalaf, R.; Maahs, Lucas; Behrens, P.; Coutinho, R.; Iyer, R.; Davies, John E.; Cypel, Marcelo; Liu, M.; Waddell, Thomas K.; Keshavjee, S.

doi:10.1016/j.healun.2015.01.746

Cited by 2 publications

(1 citation statement)

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“…Normothermic ESHP has been shown to maintain aerobic metabolism and limit exposure to cold ischemia during organ preservation. It also facilitates the delivery of pharmaceuticals to recondition dysfunctional organs, including stem cell and gene therapies ( 132 – 136 ). Finally, normothermic ESHP provides an opportunity to perform metabolic and functional assessments during the preservation interval in order to identify organs that are suitable for transplantation (Figures 2 C and 3 ) ( 22 , 137 , 138 ).…”

Section: Dcd Heart Transplantationmentioning

confidence: 99%

Transplantation of Hearts Donated after Circulatory Death

White

Messer

Large

et al. 2018

Front. Cardiovasc. Med.

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Cardiac transplantation has become limited by a critical shortage of suitable organs from brain-dead donors. Reports describing the successful clinical transplantation of hearts donated after circulatory death (DCD) have recently emerged. Hearts from DCD donors suffer significant ischemic injury prior to organ procurement; therefore, the traditional approach to the transplantation of hearts from brain-dead donors is not applicable to the DCD context. Advances in our understanding of ischemic post-conditioning have facilitated the development of DCD heart resuscitation strategies that can be used to minimize ischemia-reperfusion injury at the time of organ procurement. The availability of a clinically approved ex situ heart perfusion device now allows DCD heart preservation in a normothermic beating state and minimizes exposure to incremental cold ischemia. This technology also facilitates assessments of organ viability to be undertaken prior to transplantation, thereby minimizing the risk of primary graft dysfunction. The application of a tailored approach to DCD heart transplantation that focuses on organ resuscitation at the time of procurement, ex situ preservation, and pre-transplant assessments of organ viability has facilitated the successful clinical application of DCD heart transplantation. The transplantation of hearts from DCD donors is now a clinical reality. Investigating ways to optimize the resuscitation, preservation, evaluation, and long-term outcomes is vital to ensure a broader application of DCD heart transplantation in the future.

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