Ex-vivo cellular MRI with b-SSFP: quantitative benefits of 3 T over 1.5 T

Abstract

There are several factors that contributed to this important result. First, a greater-than-linear SNR gain was achieved in mouse brain images at 3 T. Second, a reduction in the bandwidth, and the associated increase in repetition time and SNR, produced a dramatic increase in the contrast generated by iron-labeled cells.

Tracking and evaluation of dendritic cell migration by cellular magnetic resonance imaging

“…41 The detection of iron-labeled cells depends primarily on the total amount of iron per cell (or per voxel), the echo time and spatial resolution. 42 The majority of studies utilizing MRI for the detection of ironlabeled cells have examined large groups of cells (10 6 SPIO have a similar core to USPIO, although slightly larger (7 nm), and are usually coated with dextran or carboxydextran and have a hydrodynamic diameter of roughly 60-150 nm. These coatings render the iron particles biocompatible and biodegradable.…”

Tumor metastasis, physical sciences and the value of multidisciplinary collaborations

“…These studies were facilitated by the development of novel magnetic resonance imaging (MRI) techniques and hardware ('Single Cell MRI') that allow detection of single cancer cells that remain dormant in vivo, detectable due to their retention of iron microparticles loaded into cells prior to their in vivo injection (e.g. [21][22][23][24], reviewed in [25]). Examples of iron-loaded cells in vitro and in vivo, along with in vivo mouse brain MRI images, are shown in figure 1.…”

“…The journal Convergent Science Physical Oncology is providing a valuable new forum for facilitating these interactions. [21][22][23][24] and as reviewed in [25]. Scale bars in A and B, 100 µm.…”

Supressão das anomalias de fase e batimentos laterais em espectros de RMN 13c obtidos com a sequência de precessão livre no estado estacionário

“…[1][2][3][4][5][6][7][8] Esta sequência apresenta como principal vantagem a utilização de intervalos de tempo entre os pulsos (T p ) menores que os tempos de relaxação longitudinal (T 1 ) e transversal (T 2 ). Este decréscimo de T p possibilita realizar a promediação de milhares de espectros por unidades de T 1 , proporcionando um ganho significativo na razão s/r, quando comparada com as demais sequências utilizadas na RMN.…”