Ex-vivo complexation, skin permeation, interaction and cytodermal toxicity studies of p-tertbutylcalix[4]arene nanoemulsion for radiation decontamination

Sharma, Navneet; Ojha, Himanshu; Pathak, Dharam Pal; Goel, Rajeev K.; Sharma, Rakesh

doi:10.1016/j.lfs.2016.11.007

Cited by 12 publications

(5 citation statements)

References 37 publications

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“…Calixarene nanoemulsion is a cream preparation and new to the market as compared with the other products tested. Calixarenes can chelate some transuranic elements, particularly uranium, and different preparations have been tested for decontamination of radionuclides from skin (Spagnul et al 2010a and b; Spagnul et al 2011; Phan et al 2013; Sharma et al 2017; Finet 2020).…”

Section: Resultsmentioning

confidence: 99%

“…However, to date, no experimental model seems suitable to evaluate the efficacy of these new compounds in comparison to existing ones. Decontamination of actinide-contaminated healthy skin has been studied in a number of ex vivo/in vitro models ranging from human or animal stratum corneum preparations; full thickness pig, bovine or human skin; as well as in vivo approaches, mainly using rat (Gerasimo et al 1997; Tymen et al 2000; Houpert et al 2004; Rana et al 2012; Mannis and Brandl 2015; Grivès et al 2017; Sharma et al 2017; Tazrart et al 2018). Probably the most well-known is the use of pig skin obtained from the ears or abdomen and placed in the Franz diffusion cell system.…”

Section: Introductionmentioning

confidence: 99%

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A Simple, Rapid, Comparative Evaluation of Multiple Products for Decontamination of Actinide-contaminated Rat Skin Ex Vivo

Griffiths

Devilliers

Laroche³

et al. 2021

Health Physics

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Decontamination of skin is an important medical countermeasure in order to limit potential internal contamination by radionuclides such as actinides. Minimizing skin surface contamination will ultimately prevent internal contamination and subsequent committed effective dose as well as contamination spreading. The decontamination agents tested on a rat skin ex vivo model ranged from water to hydrogel wound dressings. A surfactantcontaining cleansing gel and calixarene nanoemulsion with chelation properties demonstrated marked decontamination efficacies as compared with water or the chelator DTPA. Based on efficacy to remove different actinide physicochemical forms from skin, the results demonstrate that all products can remove the more soluble forms, but a further component of emulsifying or tensioactive action is required for less soluble forms. This indicates that for practical purposes, successful decontamination will depend on identification of the actinide element, the physicochemical form, and possibly the solvent. This study offers a simple, quick, cheap, reproducible screening method for efficacy evaluation of multiple products for removal of a variety of contaminants.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Simple, Rapid, Comparative Evaluation of Multiple Products for Decontamination of Actinide-contaminated Rat Skin Ex Vivo

Griffiths

Devilliers

Laroche³

et al. 2021

Health Physics

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“…The rat abdomen skin was used for the in vitro skin permeation/retention studies. 34,35 Female SD rats weighting 200±20 g were purchased from Henan Experimental Animal Center. Animal experiments were conducted in accordance with the guidelines for the use and care of experimental animals approved by the Animal Ethics Committee of Luoyang Normal University.…”

Section: In Vitro Skin Permeation and Retention Studies Preparation Omentioning

confidence: 99%

<p>Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention</p>

Niu¹,

Yuan²,

Chen³

et al. 2020

IJN

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“…Buccal mucosa of goat was used in the current study, obtained from a local slaughterhouse. Mucosa was washed with isotonic phosphate buffer, and then kept in normal saline to preserve it for further use [34]. The Franz diffusion cell consists of two compartments: one donor and one recipient compartment.…”

Section: In Vitro Drug Release Of the Filmsmentioning

confidence: 99%

Synthesis of thiolated arabinoxylan and its application as sustained release mucoadhesive film former

et al. 2018

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The present work aimed to synthesize thiolated arabinoxylan (TAX), and to evaluate its mucoadhesive potential. Synthesis of TAX was accomplished by esterification of arabinoxylan (AX) with thioglycolic acid (TGA). The appearance of a characteristic peak at 2516 cm in the FTIR spectrum of TAX, and presence of 6.01 ± 1.03 m moles of thiol per gram of the polymer confirmed successful thiolation of AX. The incorporation of the thiol group considerably promoted mucoadhesive strength of the polymer-viz. 3.99-fold. Moreover, in vivo safety analysis in albino rats revealed TAX to be safe in the concentration range of 750-1000 mg kg body weight. Synthesized TAX was utilized to prepare Tizanidine HCl (TZN HCl) loaded sustained release (SR) mucoadhesive buccal films using a solvent casting technique. Results proved that the prepared films were of uniform thickness, good mechanical strength (with folding endurance >300), acceptable moisture contents (5%-7%) and surface pH (6.23 ± 0.81 to 6.43 ± 0.49) compatible to that of the buccal cavity. Presence of greater that 90% of drug contents indicated the excellent drug loading ability of the prepared films. Results of in vitro dissolution studies and ex vivo permeation studies conducted respectively by USP dissolution apparatus II and Franz diffusion cell indicated that sustained effect of TAX was achieved for 8 h. These results have conclusively proven that TAX has the potential to improve the bioavailability of TZN HCl due to enhanced mucoadhesion in buccal cavity, hence signifying its suitability as a mucoadhesive buccal film former.

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Ex-vivo complexation, skin permeation, interaction and cytodermal toxicity studies of p-tertbutylcalix[4]arene nanoemulsion for radiation decontamination

Cited by 12 publications

References 37 publications

A Simple, Rapid, Comparative Evaluation of Multiple Products for Decontamination of Actinide-contaminated Rat Skin Ex Vivo

A Simple, Rapid, Comparative Evaluation of Multiple Products for Decontamination of Actinide-contaminated Rat Skin Ex Vivo

<p>Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention</p>

Synthesis of thiolated arabinoxylan and its application as sustained release mucoadhesive film former

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