Ex vivo effects of ibogaine on the activity of antioxidative enzymes in human erythrocytes

Nikolić‐Kokić, Aleksandra; Oreščanin-Dušić, Zorana; Spasojević, Ivan; Slavić, Marija; Mijušković, Ana; Paškulin, Roman; Miljević, Čedo; Spasić, Mihajlo; Blagojević, Duško

doi:10.1016/j.jep.2015.01.037

Cited by 12 publications

(27 citation statements)

References 34 publications

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“…Ibogaine's anti-addictive activity is achieved through its effects on receptors (N-methyl-D-aspartate [9], nicotinic [10], 5-hydroxytryptamine 2A (5-HT 2A ), muscarinic [1] and kappa, sigma-2 and mu opioid receptors [1]), inhibition of monoamine oxidase [1], antagonism of 5-HT and dopaminergic transporters [1], and through adaptive changes in ATP-related cell energy homeostasis [11][12][13]. Paškulin et al [14] showed an increase in the production of energy-related enzymes in rat brain after intraperitoneal (i.p.)…”

Section: Introductionmentioning

confidence: 99%

“…injection of 20 mg/kg b.w., and in yeast Saccharomyces cerevisiae [11] cultivated with ibogaine at a concentration of 1 mg/L, which corresponds to the dose in the brain. It was also shown that ibogaine caused rapid depletion of ATP that was accompanied by increased production of reactive oxygen species (ROS) [13] and activation of antioxidant defense enzymes in yeast [11]. While ibogaine in vitro did not show any significant antioxidant properties per se [12], the observed ibogaineassociated increase in activities of antioxidant enzymes (cytosolic copper-zinc superoxide dismutase (SOD1), glutathione reductase (GR) [13] and catalase (CAT) [15]) in different in vitro [12] and ex vivo [13] model systems supported ibogaine as a pro/antioxidative agent.…”

Section: Introductionmentioning

confidence: 99%

“…It was also shown that ibogaine caused rapid depletion of ATP that was accompanied by increased production of reactive oxygen species (ROS) [13] and activation of antioxidant defense enzymes in yeast [11]. While ibogaine in vitro did not show any significant antioxidant properties per se [12], the observed ibogaineassociated increase in activities of antioxidant enzymes (cytosolic copper-zinc superoxide dismutase (SOD1), glutathione reductase (GR) [13] and catalase (CAT) [15]) in different in vitro [12] and ex vivo [13] model systems supported ibogaine as a pro/antioxidative agent. In previous work on yeast [11], elevated expression of metabolic enzymes involved in glycolysis and of SOD protein were detected after 5 h at a dose of 1 mg/L ibogaine (equivalent to ibogaine levels found in brains of rats that received 20 mg/kg b.w., i.p.).…”

Section: Introductionmentioning

confidence: 99%

“…Having in mind ibogaine pharmacokinetics, as well as its influence on both energy metabolism and the activity of antioxidant enzymes explored ex vivo [11,12,15] and in vitro [13] using different doses and experimental models, herein we examined the effects of ibogaine in vivo after application of a single dose (1 or 20 mg/kg b.w., p.o.) on rat liver and erythrocytes after 6 and 24 h. Histological examination of the liver was performed in order to (i) visualize the potential changes in the amount of glycogen (as representation of energy metabolism), and (ii) to examine the possible morphological effects on hepatocytes.…”

Section: Introductionmentioning

confidence: 99%

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Effects of ibogaine per os application on redox homeostasis in rat liver and erythrocytes

Uzelac

Tatalović

Mijović

et al. 2019

ARCH BIOL SCI BELGRA

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Ibogaine, administered as a single oral dose (1-25 mg/kg body weight), has been used as an addiction-interrupting agent. Its effects persist for up to 72 h. Ex vivo results showed that ibogaine induced cellular energy consumption and restitution, followed by increased reactive oxygen species production and antioxidant activity. Therefore, the aim of this work was to explore the effect of a single oral dose of ibogaine (1 or 20 mg/kg body weight) on antioxidative defenses in rat liver and erythrocytes. Six and 24 h after ibogaine administration, histological examination showed glycogenolytic activity in hepatocytes, which was highest after 24 h in animals that received 20 mg/kg ibogaine. There were no changes in the activities of superoxide dismutases, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase in the liver and erythrocytes after ibogaine treatment, regardless of the dose. Hepatic xanthine oxidase activity was elevated in rats that received 20 mg/kg compared to the controls (p<0.01), suggesting faster adenosine turnover. TBARS concentration was elevated in the group treated with 1 mg/kg after 24 h compared to the controls (p<0.01), suggesting mild oxidative stress. Our results show that ibogaine treatment influenced hepatic redox homeostasis, but not sufficiently to remodel antioxidant enzyme activities at 6 and 24 h post-ibogaine application.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of ibogaine per os application on redox homeostasis in rat liver and erythrocytes

Uzelac

Tatalović

Mijović

et al. 2019

ARCH BIOL SCI BELGRA

View full text Add to dashboard Cite

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“…(LIU et al, 2015), antioxidante (NIKOLIĆ-KOKIĆ et al, 2015), antifúngica (ATA et al, 2010), antiespasmódica (GIRARDOT et al, 2012) LI et al, 2015;WADA et al, 2015;ZHAO et al, 2015).…”

Section: Alcaloidesunclassified

Síntese De 11a-N-Arilsulfonil-Tetrahidro-5h-Benzo[a]carbazóis Com Ação Antitumoral

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The Iboga Alkaloids

Lavaud

Massiot

2017

Progress in the Chemistry of Organic Natural Products 105

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Iboga alkaloids are a particular class of indolomonoterpenes most often characterized by an isoquinuclidine nucleus. Their first occurrence was detected in the roots of Tabernanthe iboga, a sacred plant to the people of Gabon, which made it cult object. Ibogaine is the main representative of this class of alkaloids and its psychoactive properties are well documented. It has been proposed as a drug cessation treatment and has a wide range of activities in targeting opioids, cocaine, and alcohol. The purpose of this chapter is to provide a background on this molecule and related compounds and to update knowledge on the most recent advances made. Difficulties linked to the status of ibogaine as a drug in several countries have hampered its development, but 18-methoxycoronaridine is currently under evaluation for the same purposes and for the treatment of leishmaniasis. The chapter is divided into six parts: an introduction aiming at defining what is called an iboga alkaloid, and this is followed by current knowledge on their biosynthesis, which unfortunately remains a "black box" as far as the key construction step is concerned. Many of these alkaloids are still being discovered and the third and fourth parts of the chapter discuss the analytical tools in use for this purpose and give lists of new monomeric and dimeric alkaloids belonging to this class. When necessary, the structures are discussed especially with regard to absolute configuration determinations, which remain a point of weakness in their assignments. Part V gives an account of progress made in the synthesis, partial and total, which the authors believe is key to providing solid solutions to the industrial development of the most promising molecules. The last part of the chapter is devoted to the biological properties of iboga alkaloids, with particular emphasis on ibogaine and 18-methoxycoronaridine.

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Ex vivo effects of ibogaine on the activity of antioxidative enzymes in human erythrocytes

Cited by 12 publications

References 34 publications

Effects of ibogaine per os application on redox homeostasis in rat liver and erythrocytes

Effects of ibogaine per os application on redox homeostasis in rat liver and erythrocytes

Síntese De 11a-N-Arilsulfonil-Tetrahidro-5h-Benzo[a]carbazóis Com Ação Antitumoral

The Iboga Alkaloids

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