Ex vivo evaluation of a new neonatal/infant oxygenator: comparison of the                 Terumo CAPIOX® Baby RX with Dideco Lilliput 1 and Polystan Safe Micro in the                 piglet model

Dubois, Jasperina; Jamaer, Luc; Mees, Urbain; Pauwels, JL; Briers, F; Lehaen, Jeroen; Hendrikx, Marc

doi:10.1191/0267659104pf758oa

Cited by 18 publications

(16 citation statements)

References 15 publications

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“…However, it is one aspect still controversial currently, and it is reasonable to assume that this has not occurred, because in addition to the distribution of oxygenators have been similar in both groups, Dubois et al [19] in 2004, demonstrated performance and degree of hemolysis similar of two (Lilliput and Safe Micro) of the most used in this study. In addition, Jensen et al [20] in 2003, found that a hollow fiber membrane oxygenator used here, act similarly in both coagulation and fibrinolysis systems, as in serum cytokines concentrations TNF-á, IL-6 and IL-8, which proved to be even similar when other oxygenators coated with heparin were used.…”

Section: Fig 6 -Il-6/il10 Proportion In the Aprotinin And Control Grmentioning

confidence: 78%

Avaliação da aprotinina na redução da resposta inflamatória sistêmica em crianças operadas com circulação extracorpórea

Ferreira¹,

Vicente²,

Évora³

et al. 2010

Rev Bras Cir Cardiovasc

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Avaliação da aprotinina na redução da resposta inflamatória sistêmica em crianças operadas com circulação extracorpóreaAssessment of aprotinin in the reduction of inflammatory systemic response in children undergoing surgery with cardiopulmonary bypass Abstract Objective: To assess if the hemostatic high-dose aprotinin is able to reduce the inflammatory process after cardiopulmonary bypass (CPB) in children.Methods: A prospective randomized study was performed on children aged 30 days to 4 years who underwent correction of acyanogenic congenital heart disease with CPB and were divided into two groups: Control (n=9) and Aprotinin (n=10). In the Aprotinin Group the drug was administered before and during CPB and the systemic inflammatory response and hemostatic and multiorgan dysfunctions were assessed through clinical and biochemical markers. Differences were considered to be significant when P<0.05.Results: The groups were similar regarding demographic and intraoperative variables, except for a greater hemodilution in the Aprotinin Group. The drug had no benefit regarding time of mechanical pulmonary ventilation, staying in the postoperative ICU and length of hospitalization, or regarding the use of inotropic drugs and renal function. The partial arterial oxygen pressure/ inspired oxygen fraction ratio (PaO 2 /FiO 2 ) was significantly reduced 24 h after surgery in the Control Group. Blood loss was similar for both groups. Significant leukopenia was observed in the Aprotinin Group during CPB, followed by leukocytosis. Tumor necrosis factor alpha (TNF-á), interleukins (IL)-6, IL-8, IL-10, IL-6/IL-10 ratio did not differ significantly between groups. The postoperative IL-6/IL-10 ratio increased significantly in the Control Group. There were no complications with the use of aprotinin.Conclusion: In this study, hemostatic high-dose aprotinin did not minimize the clinical manifestations or serum markers of the inflammatory systemic response. Descriptors 86FERREIRA, CA ET AL -Assessment of aprotinin in the reduction of inflammatory systemic response in children undergoing surgery with cardiopulmonary bypass Bras Cir Cardiovasc 2010; 25(1): 85-98 Rev

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Section: Fig 6 -Il-6/il10 Proportion In the Aprotinin And Control Grmentioning

confidence: 78%

Avaliação da aprotinina na redução da resposta inflamatória sistêmica em crianças operadas com circulação extracorpórea

Ferreira¹,

Vicente²,

Évora³

et al. 2010

Rev Bras Cir Cardiovasc

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“…These results correlate well with our previous clinical results under nonpulsatile perfusion, as well as other investigators' results with these identical oxygenators in a neonatal piglet model. 8,9 Changing the perfusion modes from non-pulsatile to pulsatile flow did not produce any changes in the pressure drops of the membranes in both oxygenators. However, the change in perfusion mode significantly increased SHE levels (up to five to six times compared to the baseline) in both oxygenators at pre-oxygenator, post-oxygenator, and pre-cannula stages during normothermic CPB, hypothermic CPB, and after rewarming.…”

Section: Discussionmentioning

confidence: 93%

“…1 It is also documented that there were significant differences in pressure drops among different brands of hollow-fiber membrane oxygenators in clinical as well as in animal experiments. 8,9 The objectives of this investigation were (1) to compare two hollow-fiber membrane oxygenators (Capiox Baby RX05 versus Lilliput 1-D901) in terms of pressure drops and surplus hemodynamic energy (SHE) during normothermic and hypothermic CPB in a simulated neonatal model; and (2) to evaluate pulsatile and non-pulsatile perfusion modes for each oxygenator in terms of SHE levels.…”

Section: Introductionmentioning

confidence: 99%

Comparison of hollow-fiber membrane oxygenators with different perfusion modes during normothermic and hypothermic CPB in a simulated neonatal model

Ündar

Lukic

et al. 2006

Perfusion

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“…Free serum hemoglobin samples were analyzed spectrophotometrically with a Sigma Diagnostics serum hemoglobin kit. 21 Whole blood was withdrawn from the femoral artery and centrifuged at 1000g after being allowed to clot for 2 hours. The resulting serum was stored at Ϫ80°C until measurement.…”

Section: Inflammatory Mediators and Free Serum Hemoglobinmentioning

confidence: 99%

Emboli Formation Rather Than Inflammatory Mediators Are Responsible for Increased Cerebral Water Content After Conventional and Assisted Beating-Heart Myocardial Revascularization in a Porcine Model

Bierbach¹,

Meier²,

Kasper-König³

et al. 2008

Stroke

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Background and Purpose-Emboli and proinflammatory mediators are suspected of generating cerebral edema after coronary surgery. In contrast to cardiopulmonary bypass (CPB), off-pump coronary artery bypass surgery (OPCAB) reduces microemboli count and proinflammatory mediator release but carries the risk of hemodynamic instability. A microaxial blood pump can augment cardiac output. Methods-Coronary bypasses were constructed in pigs with CPB and cardioplegia (nϭ9), OPCAB (nϭ9), or blood-pump support CAB (nϭ9). Nine animals underwent sham operation. Embolus count was monitored and regional cerebral blood flow was assessed with microspheres in 21 brain specimens per animal (nϭ189 per group). Interleukins 6 and 8 and tumor necrosis factor-␣ concentrations were determined. These variables were studied before, during, and for 4 hours after surgery. Finally, cerebral water content was determined. Results-During CPB and blood-pump CAB, a significant number of emboli were counted in contrast to OPCAB and controls (PϽ0.05). During CPB, regional cerebral blood flow was affected (32 of 189) and showed reactive hyperemia except in 10 specimens after aortic cross-clamp release. This impairment persisted in 20 specimens. During and after OPCAB, regional cerebral blood flow remained nearly unchanged but showed low flow during (58 of 189) and after (35 of 189) the blood-pump run. A significant increase in proinflammatory mediators was observed only in the CPB group. CPB and blood-pump CAB significantly increased cerebral water content (PϽ0.05). A strong correlation between embolic load and cerebral water content was observed in all groups. No correlation between proinflammatory mediator release and cerebral water content was detected. Conclusions-Emboli formation rather than inflammatory mediators are responsible for increased cerebral water content after conventional and assisted beating-heart myocardial revascularization. (Stroke. 2008;39:213-219.)

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Ex vivo evaluation of a new neonatal/infant oxygenator: comparison of the Terumo CAPIOX® Baby RX with Dideco Lilliput 1 and Polystan Safe Micro in the piglet model

Abstract: The BRX is as safe as the DL1 and the PSM, with superior performance in pressure drop, efficient blood gas management and lower haemolysis. The BRX exhibited the lowest prime, hold-up volume and breakthrough time.

Cited by 18 publications

References 15 publications

Avaliação da aprotinina na redução da resposta inflamatória sistêmica em crianças operadas com circulação extracorpórea

Avaliação da aprotinina na redução da resposta inflamatória sistêmica em crianças operadas com circulação extracorpórea

Comparison of hollow-fiber membrane oxygenators with different perfusion modes during normothermic and hypothermic CPB in a simulated neonatal model

Emboli Formation Rather Than Inflammatory Mediators Are Responsible for Increased Cerebral Water Content After Conventional and Assisted Beating-Heart Myocardial Revascularization in a Porcine Model

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