Ex-Vivo Expansion of Cardiac Stem Cell Therapy Products for Clinical Use: The Importance of Moving towards the Optimization of Process Development

Bardelli, Silvana

doi:10.23937/2469-570x/1410017

Int J Stem Cell Res Ther

2016

DOI: 10.23937/2469-570x/1410017

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Ex-Vivo Expansion of Cardiac Stem Cell Therapy Products for Clinical Use: The Importance of Moving towards the Optimization of Process Development

Silvana Bardelli¹

Abstract: The interest in stem cell-based therapies is rapidly increasing given the general progressive population ageing and as a consequence of the massive incidence of Heart Failure (HF). This urgent clinical need has prompted innovation in the field of stem cell applications towards the effort of developing new regenerative approaches.

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2016

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Stem Cell Banking and Its Impact on Cardiac Regenerative Medicine

Bardelli

Moscarelli

2016

Advances in Experimental Medicine and Biology

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Cardiovascular diseases, including heart failure, are the most frequent cause of death annually, even higher than any other pathologies. Specifically, patients who suffer from myocardial infarction may encounter adverse remodeling processes of the heart that can ultimately lead to heart failure. Prognosis of patients affected by heart failure is very poor with 5-year mortality close to 50 %. Despite the impressive progress in the clinical treatment of heart failure in recent years, heart transplantation is still required to avoid death as the result of the inexorable decline in cardiac function. Unfortunately, the availability of donor human hearts for transplantation largely fails to cover the number of potential recipient requests. From this urgent unmet clinical need the interest in stem cell applications for heart regeneration made its start, and has rapidly grown in the last decades. Indeed, the discovery and application of stem and progenitor cells as therapeutic agents has raised substantial interest with the objective of reversing these processes, and ultimately inducing cardiac regeneration. In this scenario, the role of biobanking may play a remarkable role to provide cells at the right time according to the patient's clinical needs, mostly for autologous use in the acute setting of myocardial infarction, largely reducing the time needed for cell preparation and expansion before administration.

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Stem Cell Banking and Its Impact on Cardiac Regenerative Medicine

Bardelli

Moscarelli

2016

Advances in Experimental Medicine and Biology

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Ex-Vivo Expansion of Cardiac Stem Cell Therapy Products for Clinical Use: The Importance of Moving towards the Optimization of Process Development

Cited by 1 publication

References 23 publications

Stem Cell Banking and Its Impact on Cardiac Regenerative Medicine

Stem Cell Banking and Its Impact on Cardiac Regenerative Medicine

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