Ex vivo fecal fermentation of human ileal fluid collected after raspberry consumption modifies (poly)phenolics and modulates genoprotective effects in colonic epithelial cells

Dobani, Sara; Latimer, Cheryl; McDougall, Gordon J.; Allwood, J. William; Pereira‐Caro, Gema; Moreno‐Rojas, José Manuel; Ternan, Nigel G.; Pourshahidi, L. Kirsty; Lawther, Roger; Tuohy, Kieran; Rio, Daniele Del; O’Connor, Gloria; Rowland, Ian; Almutairi, Tahani Mazyad; Crozier, Alan; Gill, Chris

doi:10.1016/j.redox.2021.101862

Cited by 24 publications

(17 citation statements)

References 49 publications

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“…Moreover, an oxidative challenge COMET assay showed that post-raspberry ileal fermentate significantly reduced (~30%) DNA damage in the CCD 841 CoN normal cell line. The results indicate that colon-available raspberry polyphenols and their microbial-derived catabolites may play a role in protection against colorectal cancer [96]. Evidence from other research confirmed the anti-cancerous potential of 4 kDa peptide derived from buckwheat.…”

Section: Anti-cancermentioning

confidence: 52%

Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview

Samtiya

Aluko

Dhewa

et al. 2021

Foods

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Plant foods are consumed worldwide due to their immense energy density and nutritive value. Their consumption has been following an increasing trend due to several metabolic disorders linked to non-vegetarian diets. In addition to their nutritive value, plant foods contain several bioactive constituents that have been shown to possess health-promoting properties. Plant-derived bioactive compounds, such as biologically active proteins, polyphenols, phytosterols, biogenic amines, carotenoids, etc., have been reported to be beneficial for human health, for instance in cases of cancer, cardiovascular diseases, and diabetes, as well as for people with gut, immune function, and neurodegenerative disorders. Previous studies have reported that bioactive components possess antioxidative, anti-inflammatory, and immunomodulatory properties, in addition to improving intestinal barrier functioning etc., which contribute to their ability to mitigate the pathological impact of various human diseases. This review describes the bioactive components derived from fruit, vegetables, cereals, and other plant sources with health promoting attributes, and the mechanisms responsible for the bioactive properties of some of these plant components. This review mainly compiles the potential of food derived bioactive compounds, providing information for researchers that may be valuable for devising future strategies such as choosing promising bioactive ingredients to make functional foods for various non-communicable disorders.

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Section: Anti-cancermentioning

confidence: 52%

Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview

Samtiya

Aluko

Dhewa

et al. 2021

Foods

Self Cite

321

147

View full text Add to dashboard Cite

show abstract

“…A reduction in tumor growth has been associated with diets supplemented with anthocyanins, flavonols, flavonones and hydrolysable tannins [80]. The antioxidant capacity of phenolic compounds, found in raspberries, is greatly due to their radical scavenging activity, since they can easily donate electrons and hydrogen atoms due to their highly conjugated systems and aromatic structures [81]. Compared with ellagitannins, anthocyanins have a higher antioxidant activity, since they can scavenge produced free radicals through two different pathways, whereas ellagitannins only use one pathway.…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Likewise, anthocyanins can reduce the expression levels of inducible nitric oxide synthase, cyclooxygenase-2, IL-1β and IL-6 [100], reducing inflammation. The anti-inflammatory activity of phenolic compounds may be due to their ability to interfere with oxidative stress signaling and suppress proinflammatory signaling transduction [81]. These compounds have been reported to block the secretion of proinflammatory cytokines [101].…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Antioxidant, Anti-Inflammatory and Cytotoxic Activity of Phenolic Compound Family Extracted from Raspberries (Rubus idaeus): A General Review

et al. 2022

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Raspberries (Rubus idaeus) possess a wide phenolic family profile; this serves the role of self-protection for the plant. Interest in these compounds have significantly increased, since they have been classified as nutraceuticals due to the positive health effects provided to consumers. Extensive chemical, in vitro and in vivo studies have been performed to prove and validate these benefits and their possible applications as an aid when treating several chronic degenerative diseases, characterized by oxidative stress and an inflammatory response. While many diseases could be co-adjuvanted by the intake of these phenolic compounds, this review will mainly discuss their effects on cancer. Anthocyanins and ellagitannins are known to provide a major antioxidant capacity in raspberries. The aim of this review is to summarize the current knowledge concerning the phenolic compound family of raspberries, and topics discussed include their characterization, biosynthesis, bioavailability, cytotoxicity, antioxidant and anti-inflammatory activities.

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“…The activity of the latter was mediated by cell cycle arrest at the G1 phase and induction of apoptosis. Dobani et al (2021) have shown that raspberry polyphenols can reduce DNA damage and protect the colonic epithelium by upregulation of the cytoprotective Nrf2/antioxidant responsive element pathway. Wang et al (2020) pointed out that tea polyphenols (TPs) can exert chemopreventive and therapeutic effects on CRC via multiple pathways mediated by gut microbiota.…”

Section: Phenolicsmentioning

confidence: 99%

Therapeutic approaches to colorectal cancer via strategies based on modulation of gut microbiota

Chen

Lin

et al. 2022

Front. Microbiol.

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Colorectal cancer (CRC) ranks third in terms of global incidence and second in terms of death toll among malignant tumors. Gut microbiota are involved in the formation, development, and responses to different treatments of CRC. Under normal physiological conditions, intestinal microorganisms protect the intestinal mucosa, resist pathogen invasion, and regulate the proliferation of intestinal mucosal cells via a barrier effect and inhibition of DNA damage. The composition of gut microbiota and the influences of diet, drugs, and gender on the composition of the intestinal flora are important factors in the early detection of CRC and prediction of the results of CRC treatment. Regulation of gut microbiota is one of the most promising new strategies for CRC treatment, and it is essential to clarify the effect of gut microbiota on CRC and its possible mechanisms to facilitate the prevention and treatment of CRC. This review discusses the role of gut microbiota in the pathogenesis of CRC, the potential of gut microbiota as biomarkers for CRC, and therapeutic approaches to CRC based on the regulation of gut microbiota. It might provide new ideas for the use of gut microbiota in the prevention and treatment of CRC in the near future and thus reduce the incidence of CRC.

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Ex vivo fecal fermentation of human ileal fluid collected after raspberry consumption modifies (poly)phenolics and modulates genoprotective effects in colonic epithelial cells

Cited by 24 publications

References 49 publications

Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview

Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview

Antioxidant, Anti-Inflammatory and Cytotoxic Activity of Phenolic Compound Family Extracted from Raspberries (Rubus idaeus): A General Review

Therapeutic approaches to colorectal cancer via strategies based on modulation of gut microbiota

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