Ex vivo water diffusion tensor properties of the fibroid uterus at 7 T and their relation to tissue morphology

Thrippleton, Michael J.; Bastin, Mark E.; Munro, Kirsty I.; Williams, Alistair; Oniscu, Anca; Jansen, Maurits A.; Merrifield, Gavin D.; McKillop, Graham; Newby, David E.; Semple, Scott; Marshall, Ian; Critchley, Hilary O. D.

doi:10.1002/jmri.22793

Cited by 6 publications

(10 citation statements)

References 18 publications

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“…The fiber architectures visualized in our study were similar to the previous reports performed ex vivo (20,21), and in vivo (19,29) where circularly arranged fibers appeared in slices taken orthogonally to the long axis of the uterine corpus. The mean FA was highest for the JZ (0.297 6 0.033), followed by the OM (0.257 6 0.022) and EM (0.186 6 0.039).…”

Section: Discussionsupporting

confidence: 89%

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Diffusion tensor imaging (DTI) of the normal human uterus in vivo at 3 tesla: Comparison of DTI parameters in the different uterine layers

Fujimoto

Kido

Okada

et al. 2013

Magnetic Resonance Imaging

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Purpose To investigate the differences in the fiber architecture and related diffusion tensor imaging (DTI) parameters among different uterine layers of the normal human uterus in vivo at 3 Tesla (T). Materials and Methods DTI of the uterus was performed for nine healthy women of reproductive age on a 3T scanner. A volume of interest (VOI) was drawn for the outer myometrium (OM), junctional zone (JZ), and endometrium (EM). Apparent diffusion coefficient (ADC), fractional anisotropy (FA), and maximum fiber length were compared using paired Student's t‐tests. Fibers were classified into four groups and were visually evaluated. Results ADC (×10−3 mm2/s) was highest for OM (1.12), followed by EM (0.97) and JZ (0.83) (OM versus JZ, P < 0.0001; JZ versus EM, P = 0.0001; OM versus EM, P = 0.0057). FA was highest for JZ (0.297), followed by OM (0.257) and EM (0.186) (OM versus JZ, P = 0.0002; JZ versus EM, P < 0.0001; OM versus EM, P < 0.0001). Fibers were longest in OM (42.0 mm), followed by JZ (34.2 mm) and EM (20.0 mm). Circularly oriented fibers were observed in 69% in OM and in 70% in JZ. Conclusion DTI of the uterus in vivo revealed layer‐wise differences in the microstructure of the uterus. J. Magn. Reson. Imaging 2013;38:1494–1500. © 2013 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 89%

“…The fiber architectures visualized in our study were similar to the previous reports performed ex vivo , and in vivo where circularly arranged fibers appeared in slices taken orthogonally to the long axis of the uterine corpus.…”

Section: Discussionsupporting

confidence: 88%

Diffusion tensor imaging (DTI) of the normal human uterus in vivo at 3 tesla: Comparison of DTI parameters in the different uterine layers

Fujimoto

Kido

Okada

et al. 2013

Magnetic Resonance Imaging

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“…Thrippleton et al (14) performed an ex vivo study with a 7T MRI and found the FA value of the leiomyomas to be around 0.20-0.28±0.053, and the myometrium as 0.395±0.032; they concluded that these findings suggest that water molecule diffusion may be fastest in a direction parallel with fibers of the myometrial muscles and dense fibroid structures (14). The differences in the FA and ADC values of the cyclic reproductive and postmenopausal endometrium are likely to determine variations in the viscosity of the interstitial space and in the ratio of the volume occupied by cells to the volume of the interstitial space.…”

Section: Discussionmentioning

confidence: 99%

Diffusion Tensor Imaging of the Uterine Zones Related to the Menstrual Cycle and Menopausal Status at 3 Tesla MRI

Kılıçkesmez¹,

Fırat

Oygen

et al. 2016

Balkan Med J

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Background: Diffusion and diffusion tensor imaging techniques (DTI) are widely available and used both in central nervous system and body imaging, including gynecological diseases. Aims: The aims of this study were to assess the capability of DTI of uterine zones in relation to the menstrual cycle and ascertain the normal apparent diffusion coefficient and fractional anisotropy values at 3T magnetic resonance imaging (MRI).

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“…The addition of DWI, and DTI sequences which serve as functional imaging in the MRI protocol for the evaluation of uterine pathologies have been offered by several papers [2,3,7,8] . Besides quantitative evaluation with values has been found out to be effective in the discrimination of malignancy from benign lesions [1720] .…”

Section: Dwi and Dti Of Diseased Uterusmentioning

confidence: 99%

Diffusion-weighted and diffusion-tensor imaging of normal and diseased uterus

Bozkurt

Nazli

et al. 2015

WJR

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Owing to technical advances and improvement of the software, diffusion weighted imaging and diffusion tensor imaging (DWI and DTI) greatly improved the diagnostic value of magnetic resonance imaging (MRI) of the pelvic region. These imaging sequences can exhibit important tissue contrast on the basis of random diffusion (Brownian motion) of water molecules in tissues. Quantitative measurements can be done with DWI and DTI by apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values respectively. ADC and FA values may be changed by various physiological and pathological conditions providing additional information to conventional MRI. The quantitative DWI assists significantly in the differentiation of benign and malignant lesions. It can demonstrate the microstructural architecture and celluler density of the normal and diseased uterine zones. On the other hand, DWI and DTI are useful for monitoring the treatment outcome of the uterine lesions. In this review, we discussed advantages of DWI and DTI of the normal and diseased uterus. Core tip: Diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) sequences greatly improved the diagnostic value of magnetic resonance imaging of the uterus with the additional benefits of functional information. They reflect the microstructural architecture and cellular density of the uterine zones and enable quantitative evaluation. Depending on this review, DWI and DTI appear to be applicable and reliable methods for demonstrating physiological changes of the uterus, benign and malignant characteristics of uterine zones

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Ex vivo water diffusion tensor properties of the fibroid uterus at 7 T and their relation to tissue morphology

Cited by 6 publications

References 18 publications

Diffusion tensor imaging (DTI) of the normal human uterus in vivo at 3 tesla: Comparison of DTI parameters in the different uterine layers

Diffusion tensor imaging (DTI) of the normal human uterus in vivo at 3 tesla: Comparison of DTI parameters in the different uterine layers

Diffusion Tensor Imaging of the Uterine Zones Related to the Menstrual Cycle and Menopausal Status at 3 Tesla MRI

Diffusion-weighted and diffusion-tensor imaging of normal and diseased uterus

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