Exacerbation of Psoriasis by the Hypolipidemic Agent, Gemfibrozil

Fisher, David A.; Elias, Peter M.; LeBoit, Philip L.

doi:10.1001/archderm.1988.01670060012006

Cited by 37 publications

(9 citation statements)

References 7 publications

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“…The other major group of drugs to lower triglycerides, the fibrates (e.g. gemfibrozil), was similarly found to be able to cause exacerbations of psoriasis, 6 although the pharmacological mechanism is different. The general importance of the lipid metabolism in the pathogenesis of eczema and psoriasis and other skin diseases has been determined previously; however, it was assumed that bezafibrate more commonly exacerbates psoriasis but that statins are more likely to cause eczema 5 .…”

mentioning

confidence: 99%

A clinical dilemma while treating hypercholesterolaemia in psoriasis

Jacobi

Highet

2003

Br J Dermatol

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confidence: 99%

A clinical dilemma while treating hypercholesterolaemia in psoriasis

Jacobi

Highet

2003

Br J Dermatol

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“…At the end of 8 weeks of the treatment with simvastatin 40 mg/d, the researchers found a statistically significant decrease in the mean PASI score. The aggravation of psoriasis was observed after gemfibrozil [25], atorvastatin [26] and pravastatin therapy [27]. Eruption or aggravation of pustular psoriasis after the treatment with statins was not observed so far.…”

Section: Discussionmentioning

confidence: 95%

Eruption of palmoplantar pustular psoriasis in patient treated with anti-androgen therapy for prostate cancer and aggravation of lesions after statin treatment

et al. 2014

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AbstractThe article focuses on the eruption of palmoplantar pustular psoriasis, which was documented in a 53-year-old man diagnosed with prostate cancer with bone metastases. This clinical finding was made during routine hormone therapy and palliative radiotherapy. The local improvement in skin lesions was achieved following administration of topical ointments and the use of UVA 311 nm radiation therapy. The management of prostate cancer in this subject resulted in malaise, onset of diabetes mellitus and increased concentration of serum lipids. Interestingly, a few days after the statin treatment was initiated, the intensive pustule eruption was observed as well as severe pain and burning sensation in the palms and soles. The dermatological treatment led to significant improvement. The patient is still receiving oncological therapy and is monitored by dermatologists on a regular basis.

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“…Several other drugs have been reported to exacerbate psoriasis, including potassium iodide, procaine, salicylate, and sulfonamides 3,66 . Miscellaneous drugs that are associated with the exacerbation of psoriasis include IFN (α, β), imiquimod, cimetidine and gemfibrozil 115–119 . Recently, the induction or exacerbation of psoriasis by cytokine therapy has also been reported, especially after IFN‐α2b administration for the treatment of hepatitis C 120 .…”

Section: Miscellaneous Drugsmentioning

confidence: 99%

The role of drugs in the induction and/or exacerbation of psoriasis

et al. 2010

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Psoriasis is a common skin disorder; knowledge of the factors that may induce, trigger, or exacerbate the disease is of primary importance in clinical practice. Drug intake is a major concern in this respect, as new drugs are constantly being added to the list of factors that may influence the course of this disease. Drug ingestion may result in exacerbation of pre-existing psoriasis, in induction of psoriatic lesions on clinically uninvolved skin in patients with psoriasis, or in precipitation of the disease in persons without family history of psoriasis or in predisposed individuals. In view of their relationship to drug-provoked psoriasis, therapeutic agents may be classified as drugs with strong evidence for a causal relationship to psoriasis, drugs about which there are considerable but insufficient data to support the induction or aggravation of the disease, and drugs that are occasionally reported to be associated with aggravation or induction. This review focuses on the most common causative agents for drug-induced, drug-triggered, or drug-aggravated psoriasis, such as β-blockers, lithium, synthetic antimalarial drugs, nonsteroidal anti-inflammatory agents, and tetracyclines, and the mechanisms of action of these drugs in the pathogenesis of psoriasis.

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Exacerbation of Psoriasis by the Hypolipidemic Agent, Gemfibrozil

Cited by 37 publications

References 7 publications

A clinical dilemma while treating hypercholesterolaemia in psoriasis

A clinical dilemma while treating hypercholesterolaemia in psoriasis

Eruption of palmoplantar pustular psoriasis in patient treated with anti-androgen therapy for prostate cancer and aggravation of lesions after statin treatment

The role of drugs in the induction and/or exacerbation of psoriasis

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