Exacerbation of radiocontrast nephrotoxicity by endothelin receptor antagonism

Wang, Andrew; Holcslaw, Terry L.; Bashore, Thomas M.; Freed, Martin I.; Miller, Diane; Rudnick, Michael R.; Szerlip, Harold M.; Thames, Marc D.; Davidson, Charles J.; Shusterman, Neil H.; Schwab, Sidney I.

doi:10.1046/j.1523-1755.2000.00012.x

Cited by 214 publications

(111 citation statements)

References 28 publications

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“…A nonselective ET antagonist increased the risk of contrast nephropathy in patients with chronic renal failure undergoing coronary angiography. These negative effects were thought to relate to an intrarenal "steal" phenomenon, due to an predominant increase of the cortical blood flow with a worsening of medullary ischemia (74).…”

Section: Endothelin Antagonismmentioning

confidence: 99%

Prevention and Treatment of Acute Renal Failure in Sepsis

Vriese

2003

Journal of the American Society of Nephrology

112

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Section: Endothelin Antagonismmentioning

confidence: 99%

Prevention and Treatment of Acute Renal Failure in Sepsis

Vriese

2003

Journal of the American Society of Nephrology

112

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“…The use of theophylline or aminophylline has been assessed in nine clinical trials, and the results were conflicting. [41][42][43][44] Other vasodilating drugs that showed no benefit as compared with placebo in preventing CN were the atrial natriuretic peptide, 45 endothelin antagonists, 46 prostaglandin E 1 , 47 ACE inhibitors 2,48 , and L-arginine. 49 In reality, endothelin antagonists not only did not benefit but also increased the risk of CN for users.…”

Section: Saline Solutionmentioning

confidence: 99%

“…49 In reality, endothelin antagonists not only did not benefit but also increased the risk of CN for users. 46 Prophylactic hemofiltration has been associated with a reduction in the adverse events related to CN in high risk patients. 50,51 On the other hand, early dialysis after contrast medium use showed no benefit regarding the development of CN.…”

Section: Saline Solutionmentioning

confidence: 99%

Prevenção de nefrotoxicidade por contraste com solução de bicarbonato: resultados preliminares e revisão da literatura

Silva¹,

Silva²,

Lucchesi³

et al. 2010

J. Bras. Nefrol.

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“…Acute diarrheal diseases, acute glomerulonephritis, tropical infections (mainly malaria and leptospirosis), environmental agents and snakebite are the common causes of AKI. 3 Acute radio contrast nephropathy (ACN) is an important cause of AKI in hospitalized patients undergoing contrast-based procedure. 4 SCr has been the predominant marker of renal function in clinical practice for more than half a century and its limitations are well documented.…”

Section: Introductionmentioning

confidence: 99%

Serum neutrophil gelatinase-associated lipocalin as an early biomarker of acute kidney injury in subjects undergoing percutaneous transluminal coronary angiogram with normal EGFR

Sonagra¹,

Makandar²,

Patnaik³

et al. 2020

IJCBR

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Introduction: Detecting AKI in a timely fashion with the current AKIN staging criteria is a challenge because the diagnosis of AKI is usually based on changes in serum creatinine (SCr) which is a poor marker of early renal dysfunction. Aim: To study the role of Serum Neutrophil Gelatinase-Associated Lipocalcin (NGAL) as early biomarker for the detection of Contrast induced acute kidney injury (CIAKI) in subjects undergoing Percutaneous transluminal coronary angiogram (PTCA) with normal eGFR. Materials and Methods: Prospective cohort study was conducted, where SCr and serum NGAL were serially measured in a heterogeneous group of subjects (n=60) presenting to cardiology department. Results: The study population consisted of 60 subjects. All subjects were divided into 2 groups "CIAKI group" and "no-CIAKI group" according to predefined definition. The serum NGAL increased and reached its peak at 4 hours after contrast media (CM) administration and did not returned to baseline by 24 hours while the SCr increased at 24 hours and reached peak at 48 hours respectively (P<0.001).Thus, 4 hours after CM administration were considered to be appropriate time point for NGAL measurement and there was no significant correlation between serum NGAL with SCr at 0 hours, 4hours, 24 hours and 48hours. Conclusion: In our study, we found that serum NGAL promises to be a simple, safe, non-invasive and reliable early biomarker for predicting possible onset of CIAKI following contrast administration.

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Exacerbation of radiocontrast nephrotoxicity by endothelin receptor antagonism

Abstract: In patients with chronic renal insufficiency who were undergoing cardiac angiography, endothelin receptor antagonism with SB 209670 and intravenous hydration exacerbate radiocontrast nephrotoxicity compared with hydration alone.

Cited by 214 publications

References 28 publications

Prevention and Treatment of Acute Renal Failure in Sepsis

Prevention and Treatment of Acute Renal Failure in Sepsis

Prevenção de nefrotoxicidade por contraste com solução de bicarbonato: resultados preliminares e revisão da literatura

Serum neutrophil gelatinase-associated lipocalin as an early biomarker of acute kidney injury in subjects undergoing percutaneous transluminal coronary angiogram with normal EGFR

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