Exacerbation of Undiagnosed Mycosis Fungoides During Treatment With Etanercept

A Case of Mycosis Fungoides with Large Cell Transformation Associated with Infliximab Treatment

“…To the best of our knowledge, 14 cases have been reported in English language publications in which TNF-α inhibitors were associated with the onset or exacerbation of MF (4)(5)(6)(7)9). A review reported that, among 1,298 patients treated with infliximab, one Hodgkin's lymphoma and 3 non-Hodgkin's lymphomas were observed (10).…”

“…Blockade of TNF-α, however, is profoundly immuno suppressive, resulting in reactivation of tuberculosis and histoplasmosis, as well as the emergence of malignant lymphomas (3). In fact, some cases with MF manifested by treatment with TNF-α inhibitors have been reported (4)(5)(6)(7). We describe here a 60-year-old woman diagnosed with psoriasis who showed exacerbation of MF with large cell transformation during treatment with infliximab.…”

Cutaneous Gamma/Delta T-cell Lymphoma During Treatment with Etanercept for Rheumatoid Arthritis

“…To our knowledge, only a few cases of primary cutaneous lymphoma during anti-TNF-a treatment were reported previously (3)(4)(5)(6)(7)(8)(9)(10)(11). Most reports concerned cases of mycosis fungoides.…”

Cutaneous Lymphoproliferative Disorders in Other Iatrogenic and Non‐Iatrogenic Immune Deficiencies

“…In recent years, the onset of cutaneous or extracutaneous lymphomas has been described also in patients undergoing treatment with immunosuppressive or immunomodulatory drugs ("biologics") [5][6][7][8][9][10]. In some of these cases, a wrong diagnosis of atopic dermatitis or psoriasis had been made and treatment with one of the many immunologic agents had been started, resulting in rapid progression of an undiagnosed mycosis fungoides (see also Chapter 2) [7][8][9]. These particular cases have been termed "monoclonal antibody immunomodulator-related lymphoid proliferations" [10].…”