Exacerbations in Idiopathic Pulmonary Fibrosis Triggered by Pulmonary and Nonpulmonary Surgery: A Case Series and Comprehensive Review of the Literature

Ghatol, Abhijeet; Ruhl, A. Parker; Danoff, Sonye K.

doi:10.1007/s00408-012-9389-5

Cited by 86 publications

(58 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, idiopathic AE-IPF is more common in the winter months [24,30], and in patients that are immunosuppressed [9], indicating that some cases of idiopathic AE-IPF may be triggered by a preceding infection [40][41][42]. Additional potential triggers that can lead to a similar presentation in patients with IPF include aspiration [43,44], pollution [45], thoracic surgical procedures [20,25,26,37,[46][47][48][49][50], cryobiopsy [51] and, possibly, bronchoalveolar lavage [20,52]. AE-IPF has also been reported following non-pulmonary surgery [47], potentially related to mechanical trauma secondary to mechanical ventilation.…”

Section: Aetiology and Risk Factorsmentioning

confidence: 99%

“…Additional potential triggers that can lead to a similar presentation in patients with IPF include aspiration [43,44], pollution [45], thoracic surgical procedures [20,25,26,37,[46][47][48][49][50], cryobiopsy [51] and, possibly, bronchoalveolar lavage [20,52]. AE-IPF has also been reported following non-pulmonary surgery [47], potentially related to mechanical trauma secondary to mechanical ventilation. Acute lung injury similar to AE-IPF can also occur secondary to direct pulmonary toxicity from medications or thoracic radiation [53,54], particularly chemotherapy and immunosuppressive biological therapies.…”

Section: Aetiology and Risk Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Acute exacerbation of idiopathic pulmonary fibrosis: shifting the paradigm

et al. 2015

View full text Add to dashboard Cite

The goal of this review is to summarise the clinical features, management, and prognosis of acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF). AE-IPF has previously been defined based on clinical and radiological features that include the subacute onset of dyspnoea, bilateral ground glass changes on chest high-resolution computed tomography, and the absence of an identifiable aetiology. The annual incidence of AE-IPF is typically reported at 5-15%, but is less common in mild disease. Features of diffuse alveolar damage are present when a biopsy is performed. Idiopathic pulmonary fibrosis (IPF) patients with acute respiratory worsening are often initially treated with high dose corticosteroids and antimicrobials; however, there are no clear data to support these therapies, and the short-term mortality of AE-IPF is ∼50%. Recent studies have shown that the features and prognosis of AE-IPF are similar to other causes of acute respiratory worsening, including infection, aspiration, air pollution and mechanical injury to the alveolar epithelium. Based on this emerging evidence, we propose a novel approach to the classification of acute respiratory worsening events in patients with IPF that focuses on clinical and radiological findings consistent with an underlying pathobiology of diffuse alveolar damage. @ERSpublications A review summarising the features, management, and prognosis of acute exacerbations of idiopathic pulmonary fibrosis

show abstract

Section: Aetiology and Risk Factorsmentioning

confidence: 99%

Section: Aetiology and Risk Factorsmentioning

confidence: 99%

Acute exacerbation of idiopathic pulmonary fibrosis: shifting the paradigm

et al. 2015

View full text Add to dashboard Cite

show abstract

“…LESLIE [31] argues that in these areas the traction forces and alveolar collapse are greatest, leading to sheer stress, lung injury and activation of fibrotic cascades. By analogy, mechanical ventilation in IPF can be a risk factor for acute exacerbations of the pulmonary fibrosis [32]. If pressure differences play a role in the pathogenesis of IPF, it could be speculated that the pressure differences caused by cough might influence disease behaviour itself.…”

Section: Pathophysiology Of Cough In Ipfmentioning

confidence: 99%

Cough in idiopathic pulmonary fibrosis

et al. 2016

View full text Add to dashboard Cite

Many patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF, which is most probably "multifactorial" and influenced by mechanical, biochemical and neurosensory changes, with an important role for comorbidities as well. Clinical trials of cough treatment in IPF are emerging, and cough is increasingly included as a secondary end-point in trials assessing new compounds for IPF. It is important that such studies include adequate end-points to assess cough both objectively and subjectively. This article summarises the latest insights into chronic cough in IPF. It describes the different theories regarding the pathophysiology of cough, reviews the different methods to assess cough and deals with recent and future developments in the treatment of cough in IPF. @ERSpublications Latest insights into pathophysiology of cough, methods to assess cough and developments in treatment of cough in IPF http://ow.ly/YfVAH

show abstract

“…Such cases have severe dyspnea even at rest. Reduced forced vital capacity (FVC), non-smoker, and elevation of Krebs von den Lungen-6 (KL-6) have been reported as candidate risk factors for AE [15][16][17][18]. Recently, Arai et al [19] reported a diffuse HRCT pattern, lower serum IgG, and higher serum surfactant protein-D in AE diagnosis.…”

Section: Clinical Symptomsmentioning

confidence: 99%

Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Kishaba

2017

Eurasian J Med

View full text Add to dashboard Cite

Idiopathic pulmonary fibrosis (IPF) is the most common cause of chronic diffuse parenchymal disease of unknown cause. However, IPF patients sometimes develop acute exacerbation (AE), which is a life-threatening condition. The cause of AE of IPF remains unknown. The new criteria for AE of IPF have been proposed last year, wherein both idiopathic and triggered AE were proposed. Triggered AE includes infection, post-procedure and post-operation, drug toxicity, and aspiration. Therefore, detailed history taking is crucial. In this review, the definition, clinical symptoms, chest imaging, management, and prognosis for AE of IPF are described.

show abstract

Exacerbations in Idiopathic Pulmonary Fibrosis Triggered by Pulmonary and Nonpulmonary Surgery: A Case Series and Comprehensive Review of the Literature

Cited by 86 publications

References 26 publications

Acute exacerbation of idiopathic pulmonary fibrosis: shifting the paradigm

Acute exacerbation of idiopathic pulmonary fibrosis: shifting the paradigm

Cough in idiopathic pulmonary fibrosis

Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Contact Info

Product

Resources

About