Recently, a second-order formalism of piezoelectric structures under an external mechanical stress was developed. Because the yield strength of lithium niobate was unknown, this study was not able to describe and evaluate realistic benefits of a prestress load on electromechanical properties. Therefore, in this study, experimental determination of the yield strength of lithium niobate sample is performed and shows that this limit is close to 110 MPa. Then, the nonlinearities and evolutions of electroacoustic parameters of this piezoelectric material under mechanical stress are numerically studied. By varying the initial prestress, as well as azimuthal and elevation angles, the cut planes in which a prestress induces significant benefits on velocities and coupling coefficient are identified. Finally, approximate relations describing changes between electroacoustic parameters defined in the two coordinate systems of the study are determined.