Exact solution of the hydrodynamic focusing driven by hydrostatic pressure

Minetti, Florencia; Giorello, Antonella; Olivares, María Laura

doi:10.1007/s10404-020-2322-y

Cited by 5 publications

(5 citation statements)

References 50 publications

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“…However, the external equipment and algorithm modulation are complex. Secondly, the gravity-driven method can be used for microparticle manipulation [111,112]. For example, Devendra and Drazer [112] changes the angle of the separation device.…”

Section: Gravity-drivenmentioning

confidence: 99%

“…It utilizes particle gravity as the driving force to realize the microparticle separation based on gravity-driven deterministic lateral displacement (DLD), as shown in figure 11(b). Unlike the above research, Minetti et al [111] use hydrostatic pressure to provide accurate gravity-driven flow for the hydrodynamic focusing the microfluidic nanoprecipitation. However, the flow rate is very low, and the increasing throughout will reduce the separation quality.…”

Section: Gravity-drivenmentioning

confidence: 99%

See 1 more Smart Citation

A comprehensive review on non-active micro-pumps for microfluidic platforms

Wang

Yuan

Yang

et al. 2021

J. Micromech. Microeng.

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In conventional microfluidic systems, the flow drives, and controls rely principally on external pumps, which have severely prevented the applications for point-of-care testing and disposable biomedicine because of the factors such as high price, large volume, and the electricity-fueled. Several modern portable pumps have therefore been built in recent years to resolve this problem. We give a comprehensive description of non-active microfluidic systems pumps in this study. These pumps have been split into two groups in terms of their operating mechanisms: human-powered and passive pumps. The ‘human-powered’ pumps are directly powered by the human hand or finger; the passive pumps are powered by kinds of basic machinery including capillary control, siphoning, chemical reaction, vacuum pressure, osmotic pressure, and gravity. In addition, many explanations of the configurations, capability and limitations are given. Finally, it discusses emerging developments and potential strategies for extending the usage of the pumps on microfluidic platforms.

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Section: Gravity-drivenmentioning

confidence: 99%

Section: Gravity-drivenmentioning

confidence: 99%

A comprehensive review on non-active micro-pumps for microfluidic platforms

Wang

Yuan

Yang

et al. 2021

J. Micromech. Microeng.

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“…The difference between flow-rate control using syringe or peristaltic pumps and pressure pumps has mostly been studied in the case of immiscible [10] or miscible [11] two-phase flows. Guidelines have been provided to adapt the design of channels to pressure flow control [12,13]. Positive pressure at the inlet can be imposed by a pressure manifold fed with compressed air [14,15] or by fluid columns [16].…”

Section: Introductionmentioning

confidence: 99%

Flow rate variations in microfluidic circuits with free surfaces

Messelmani,

Zarpellon Nascimento,

Leclerc

et al. 2023

Microfluid Nanofluid

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We investigate analytically and experimentally the flow rate through a biochip in a circuit involving a peristaltic pump and reservoirs with liquid/air interfaces. Peristaltic pumps are a convenient way to achieve recirculation in microfluidic circuits. We consider different cases: reservoirs in contact with ambient air, tight reservoirs, and imperfect tightness leading to air or liquid leaks. We demonstrate that if changes in hydraulic resistance are slow enough, i.e. if cells do not proliferate too fast, the system may reach an equilibrium, with a difference in liquid height between inlet and outlet reservoir compensating the pressure drop in the biochip. We compute the flow rate through the biochip in the transient regime as well as the characteristic time. We also show that depending on the circuit dimensions, this equilibrium may never be reached. We provide guidelines to design tubings and reservoirs to avoid this situation and ensure a smooth recirculation at a desired flow rate, which is a necessary condition for dynamic cell culture.

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“…As a solution to this problem, we proposed the integration of a hydrodynamic flow focusing technique to reduce the particle dispersion that involves a TAMA in an F DEP application. There are different unique microelectrode designs with flow focusing combinations that have been reported [ 33 , 34 , 35 ]. According to Shkolnikov et al, the manipulation of particles has achieved an 80% separation efficiency by the integration of the F DEP and the hydrodynamic flow focusing technique [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

“…This advantage can lead to a hydrodynamic flow focusing technique. Hydrodynamic flow focusing is a technique in which a sheath fluid is introduced from the side to the side of the main flow to squeeze the flow sample [ 34 ]. The inability of the sample fluid to mix with the sheath fluid in the laminar flow region is the reason for producing flow-focusing with a different flow rate ratio.…”

Section: Introductionmentioning

confidence: 99%

Integration of a Dielectrophoretic Tapered Aluminum Microelectrode Array with a Flow Focusing Technique

Rashid

Deivasigamani

Wee

et al. 2021

Sensors

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We present the integration of a flow focusing microfluidic device in a dielectrophoretic application that based on a tapered aluminum microelectrode array (TAMA). The characterization and optimization method of microfluidic geometry performs the hydrodynamic flow focusing on the channel. The sample fluids are hydrodynamically focused into the region of interest (ROI) where the dielectrophoresis force (FDEP) is dominant. The device geometry is designed using 3D CAD software and fabricated using the micro-milling process combined with soft lithography using PDMS. The flow simulation is achieved using COMSOL Multiphysics 5.5 to study the effect of the flow rate ratio between the sample fluids (Q1) and the sheath fluids (Q2) toward the width of flow focusing. Five different flow rate ratios (Q1/Q2) are recorded in this experiment, which are 0.2, 0.4, 0.6, 0.8 and 1.0. The width of flow focusing is increased linearly with the flow rate ratio (Q1/Q2) for both the simulation and the experiment. At the highest flow rate ratio (Q1/Q2 = 1), the width of flow focusing is obtained at 638.66 µm and at the lowest flow rate ratio (Q1/Q2 = 0.2), the width of flow focusing is obtained at 226.03 µm. As a result, the flow focusing effect is able to reduce the dispersion of the particles in the microelectrode from 2000 µm to 226.03 µm toward the ROI. The significance of flow focusing on the separation of particles is studied using 10 and 1 µm polystyrene beads by applying a non-uniform electrical field to the TAMA at 10 VPP, 150 kHz. Ultimately, we are able to manipulate the trajectories of two different types of particles in the channel. For further validation, the focusing of 3.2 µm polystyrene beads within the dominant FDEP results in an enhanced manipulation efficiency from 20% to 80% in the ROI.

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Exact solution of the hydrodynamic focusing driven by hydrostatic pressure

Cited by 5 publications

References 50 publications

A comprehensive review on non-active micro-pumps for microfluidic platforms

A comprehensive review on non-active micro-pumps for microfluidic platforms

Flow rate variations in microfluidic circuits with free surfaces

Integration of a Dielectrophoretic Tapered Aluminum Microelectrode Array with a Flow Focusing Technique

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