In this investigation the attention is given to a mathematical model of the non-Newtonian Casson liquid over an unsteady stretching sheet under the combined effects of different natural parameters with heat transfer in the presence of suction/injection phenomena. The movement of a laminar thin liquid film and associated heat transfer from a horizontal stretching surface is studied. Magnetic field is proposed perpendicular to the direction of flow, while surface tension is varied quadratically with temperature of the conducting fluid. Further, variable viscosity and thermal conductivity (linear function of temperature) of the flow are examined. The transformation allows to convert the boundary layer model to a system of nonlinear ODEs (ordinary differential equations). Analytical and numerical solutions of the resulting nonlinear ODEs are obtained by using HAM and BVP4C package. Thickness of the boundary layer is investigated by both methods for a classical selection of the unsteadiness parameter. A selection of the parameter ranges is studied for better solution of the problem. Present observation displays the joined effects of magnetic field, surface tension, suction/injection, and slippage at the boundary is to improve the thermal boundary layer thickness. Results for the heat flux (Nusselt number), skin friction coefficient, and free surface temperature are granted graphically and in a table form. Similarly, the effects of natural parameters on the velocity and temperature profiles are investigated. which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.