Exaggerated Liver Injury Induced by Ischemia–Reperfusion in Spontaneously Hypertensive Rats

Ohmori, Masami; Araki, Nobutaka; Harada, Kenichi; Sudoh, Toshiaki; Sugimoto, Koh‐ichi; Fujimura, Akio

doi:10.1016/j.amjhyper.2005.05.025

Cited by 1 publication

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“…Hypertension in the recipient or donor, longer CIT or WIT, and male donor were identified as risk factors of moderate to severe IRI. Ohmori et al reported that the counts of PMNs and their functions are elevated in hypertensive patients and spontaneously hypertensive rats (SHRs) compared to humans and normal rats, which, in turn, contributes to the development of liver IRI damage in hypertensive rats 34,35 . Of interest, an analysis of 3844 adult patients from the Scientific Registry of Transplant Recipients (SRTR) database indicated that hypertensive donor grafts are associated with poor prognosis in liver‐kidney transplantation 36 .…”

Section: Discussionmentioning

confidence: 99%

Ischemia-reperfusion injury and its relationship with early allograft dysfunction in liver transplant patients

Itô

Naini

Markovic

et al. 2021

American Journal of Transplantation

102

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Ischemia‐reperfusion injury (IRI) is believed to contribute to graft dysfunction after liver transplantation (LT). However, studies on IRI and the impact of early allograft dysfunction (EAD) in IRI grafts are limited. Histological IRI was graded in 506 grafts from patients who had undergone LT and classified based on IRI severity (no, minimal, mild, moderate, and severe). Of the 506 grafts, 87.4% had IRI (no: 12.6%, minimal: 38.1%, mild: 35.4%, moderate: 13.0%, and severe: 0.8%). IRI severity correlated with the incidence of EAD and graft survival at 6 months. Longer cold/warm ischemia time, recipient/donor hypertension, and having a male donor were identified as independent risk factors for moderate to severe IRI. Among 70 grafts with moderate to severe IRI, 42.9% of grafts developed EAD, and grafts with EAD had significantly inferior survival compared to grafts without EAD. Longer cold ischemia time and large droplet macrovesicular steatosis (≥20%) were identified as independent risk factors for EAD. Our study demonstrated that increased IRI severity was correlated with inferior short‐term graft outcomes. Careful consideration of IRI risk factors during donor‐recipient matching may assist in optimizing graft utilization and LT outcomes. Furthermore, identification of risk factors of IRI‐associated EAD may guide patient management and possible timely graft replacement.

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Section: Discussionmentioning

confidence: 99%