Exaggerated pressor responses, but unaltered blood flow regulation and functional sympatholysis during lower limb exercise in young, non-Hispanic black males

Hogwood, Austin C.; Decker, Kevin; Darling, Ashley; Weggen, Jennifer; Chiu, Alex; Richardson, Jacob; Garten, Ryan S.

doi:10.1016/j.mvr.2022.104445

Cited by 1 publication

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“…Indeed, redox imbalance can act to directly or indirectly neutralize numerous vasodilatory molecules and increase the production of circulating and endothelial‐derived vasoconstrictors resulting in peripheral vascular dysfunction (Wray et al., 2017). Elevated pressor responses during exercise can result from substantial peripheral vascular dysfunction, as augmented MAP serves to augment limb perfusion pressure to overcome any inadequate limb perfusion during exercise (Grotle et al., 2020; Hogwood et al., 2023). In support of this, prior work by our group identified lower microvascular function in the upper limb of young individuals with PTSD (Weggen et al., 2021), providing evidence of peripheral vascular dysfunction as a potential mediator of this augmented exercise‐induced MAP response observed in some, but not all, participants with PTSD.…”

Section: Discussionmentioning

confidence: 99%

Lower vascular conductance responses to handgrip exercise are improved following acute antioxidant supplementation in young individuals with post‐traumatic stress disorder

Weggen,

Darling,

Autler

et al. 2024

Experimental Physiology

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Young individuals with post‐traumatic stress disorder (PTSD) display peripheral vascular and autonomic nervous system dysfunction, two factors potentially stemming from a redox imbalance. It is currently unclear if these aforementioned factors, observed at rest, alter peripheral haemodynamic responses to exercise in this population. This study examined haemodynamic responses to handgrip exercise in young individuals with PTSD following acute antioxidant (AO) supplementation. Thirteen young individuals with PTSD (age 23 ± 3 years), and 13 age‐ and sex‐matched controls (CTRL) participated in the study. Exercise‐induced changes to arm blood flow (BF), mean arterial pressure (MAP) and vascular conductance (VC) were evaluated across two workloads of rhythmic handgrip exercise (3 and 6 kg). The PTSD group participated in two visits, consuming either a placebo (PL) or AO prior to their visits. The PTSD group demonstrated significantly lower VC (P = 0.04) across all exercise workloads (vs. CTRL), which was significantly improved following AO supplementation. In the PTSD group, AO supplementation improved VC in participants possessing the lowest VC responses to handgrip exercise, with AO supplementation significantly improving VC responses (3 and 6 kg: P < 0.01) by blunting elevated exercise‐induced MAP responses (3 kg: P = 0.01; 6 kg: P < 0.01). Lower VC responses during handgrip exercise were improved following AO supplementation in young individuals with PTSD. AO supplementation was associated with a blunting of exercise‐induced MAP responses in individuals with PTSD displaying elevated MAP responses. This study revealed that young individuals with PTSD exhibit abnormal, peripherally mediated exercise responses that may be linked to a redox imbalance.

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