Examination of antitumor potential of some acylpyruvates, interaction with DNA and binding properties with transport protein

Mihajlović, Kristina; Joksimović, Nenad; Radisavljević, Snežana; Petronijević, Jelena; Filipović, Ignjat; Janković, Nenad; Milović, Emilija; Popović, Suzana; Matić, Sanja; Baskić, Dejan

doi:10.1016/j.molstruc.2022.133943

Journal of Molecular Structure

2022

DOI: 10.1016/j.molstruc.2022.133943

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Examination of antitumor potential of some acylpyruvates, interaction with DNA and binding properties with transport protein

Kristina Mihajlović

Nenad Joksimović²,

Snežana Radisavljević³

et al.

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Cited by 7 publications

References 39 publications

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Synthesis, characterization, and biological evaluation of novel cobalt(II) complexes with β-diketonates: crystal structure determination, BSA binding properties and molecular docking study

Joksimović,

Petronijević,

Ćoćić

et al. 2024

J Biol Inorg Chem

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Synthesis, characterization, and biological evaluation of novel cobalt(II) complexes with β-diketonates: crystal structure determination, BSA binding properties and molecular docking study

Joksimović,

Petronijević,

Ćoćić

et al. 2024

J Biol Inorg Chem

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New dinuclear gold(III) complex with 1,5-naphthyridine as bridging ligand: synthesis, characterization, DNA/BSA binding studies, and anticancer activity

Radisavljević,

Ćoćić,

Petrović

et al. 2024

Gold Bull

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With the aim to reveal the antitumor drug which possesses improved activity compared with cisplatin, we synthesized the new dinuclear gold(III) complex with 1,5-naphthyridine as bridging ligand. Further, the newly synthesized complex was characterized by various techniques to con rm the structure. The stability of this complex in water and in PBS buffer was investigated by UV-Vis spectroscopy. DNA binding studies were examined by UV-Vis, uorescence spectroscopy and viscosity measurements. The competitive studies with EB or HOE were done by uorescence spectroscopy. The results showed that the dinuclear gold(III) complex interacts with calf-thymus DNA (CT-DNA) via covalently binding mode. Furthermore, the investigated complex shows high value of binding constants for the interaction with bovine serum albumin (BSA) as well as for the interactions in the presence of site markers (eosin Y or ibuprofen). Dinuclear gold(III) complex induced remarkable cytotoxicity on HCT116 and MDA-MB-231 cancer cell lines, 24 and 72 h after treatment. The complex also showed selectivity and induced signi cantly lower cytotoxic activity on healthy cells compared to cancers. In support of the antitumor activity of this complex, the proapoptotic activity (via increased caspase 9 activity) and low percentages of necrosis were observed. All experimentally obtained results were corroborated by molecular docking simulations.

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Synthesis, characterization, and biological activity of some 2,4-diketo esters containing dehydrozingerone fragment: DNA and protein binding study

Mihajlović

Joksimović

Janković

et al. 2023

Bioorganic & Medicinal Chemistry Letters

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Examination of antitumor potential of some acylpyruvates, interaction with DNA and binding properties with transport protein

Cited by 7 publications

References 39 publications

Synthesis, characterization, and biological evaluation of novel cobalt(II) complexes with β-diketonates: crystal structure determination, BSA binding properties and molecular docking study

Synthesis, characterization, and biological evaluation of novel cobalt(II) complexes with β-diketonates: crystal structure determination, BSA binding properties and molecular docking study

New dinuclear gold(III) complex with 1,5-naphthyridine as bridging ligand: synthesis, characterization, DNA/BSA binding studies, and anticancer activity

Synthesis, characterization, and biological activity of some 2,4-diketo esters containing dehydrozingerone fragment: DNA and protein binding study

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