Cable-in-conduit conductors, known as CICCs, were developed for constructing superconducting coils in tokamak fusion reactors. To achieve large currents in high magnetic field, CICCs were utilized with a short-twist-pitch (STP) cable pattern to prevent irreversible performance degradation, but also inducing higher AC losses. Institute Of Plasma Physics Chinese Academy Of Sciences (ASIPP) designed and manufactured three innovative CICCs, all featuring CWS (copper wire with a short-twist-pitch wound around superconducting strands with a long-twist-pitch) structure to increase both the current density and structure stiffness of CICC cable. These CICCs had the same new CWS cable pattern but the Nb3Sn superconducting strands were from different suppliers. All samples were subsequently tested under electromagnetic cycling tests in SULTAN. For similar electromagnetic performance degradation, the Lorentz load threshold of the CWS cable pattern exhibited to be higher than that of STP cable pattern. Moreover, the AC losses of CWS were 15% lower than that of STP cable pattern for low frequencies of the applied alternating magnetic field. Both results indicated that the CWS cable pattern has a higher margin of engineering safety and lower AC losses than STP cable pattern under the target operating conditions. This provides new insights in finding solutions for optimizing the CICCs’ cable pattern and preventing its electromagnetic performance degradation.