Examination of long-lasting parental concern after false-positive results of neonatal hearing screening

Ploeg, C.P.B. van der; Lanting, C.I.; Boer, M.A. Kauffman-de; Uilenburg, Noëlle; Ridder-Sluiter, J.G. de; Verkerk, P.H.

doi:10.1136/adc.2007.129320

Cited by 22 publications

(11 citation statements)

References 26 publications

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“…Low PPV of the initial hearing screening step is a limitation of the conventional NHS program, because it brings unnecessary parental anxiety 19 and increases healthcare cost for follow-up evaluations. 20 Studies have reported PPVs of 2.2% to 15% in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Nationwide population genetic screening improves outcomes of newborn screening for hearing loss in China

Wang

Xiang

Sun

et al. 2018

Preprint

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Purpose: Concurrent newborn hearing and genetic screening has been reported, but its benefits have not been statistically proven due to limited sample sizes and outcome data. To fill this gap, we analyzed outcomes of a large number of newborns with genetic screening results.Methods: Newborns in China were screened for 20 hearing-loss-related genetic variants from 2012-2017. Genetic results were categorized as positive, at-risk, inconclusive, or negative. Hearing screening results, risk factors, and up-to-date hearing status were followed-up via phone interviews. Results:We completed genetic screening on one million newborns and followed up 12,778.We found that a positive genetic result significantly indicated a higher positive predictive value of the initial hearing screening (60% vs. 5.0%, P<0.001) and a lower rate of loss-to-follow-up (5% vs. 22%, P<0.001) than an inconclusive one. Importantly, 42% of subjects in the positive group with reported or presymptomatic hearing loss were " missed" by conventional hearing screening. Furthermore, genetic screening identified 0.23% of subjects predisposed to preventable ototoxicity. Conclusion:Our results demonstrate that limited genetic screening identified additional cases, reduced loss-to-follow-up, and informed families of ototoxicity risks, providing convincing evidence to support integrating genetic screening into universal newborn hearing screening programs.

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Section: Discussionmentioning

confidence: 99%

Nationwide population genetic screening improves outcomes of newborn screening for hearing loss in China

Wang

Xiang

Sun

et al. 2018

Preprint

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“…Even though the number was small but this group of mothers might need an intervention by a counselor. However, in a study of long-lasting parental concern after falsepositive results of neonatal hearing screening, van der Ploeg et al had made a conclusion that the test results do not cause long-term general parental anxiety [19]. Nevertheless, they noted a proportion of parents continued to experience hearing-specific worries even after 6 months of screening.…”

Section: [ ( ) T D $ F I G ]mentioning

confidence: 94%

“…The mothers of the baby with high risk to have hearing problem as registered in High Risk Criteria for Hearing Loss in Infants were excluded from the study [18]. Sample size was calculated using single proportion formula based on the prevalence of parental worry about their child's hearing after falsepositive results at 10-15% [19]. After considering 20% drop out during the follow up, 60 mothers were needed in this study where they were chosen by using simple random sampling.…”

Section: Methodsmentioning

confidence: 99%

Anxiety of the mothers with referred baby during Universal Newborn Hearing Screening

Khairi

Rafidah

Asghari

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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“…However, in this study the age of the infants in both groups differed which may have had a substantial effect on the results [8]. Another controlled study found that false-positive results after newborn hearing screening did not cause long-term parental anxiety in the majority of the parents [6]. During a study comparing two novel strategies for NBSCF we investigated whether or not increased parental anxiety induced by a false-positive screening test persisted after six months [9].…”

Section: Introductionmentioning

confidence: 91%

“…Long-lasting parental stress after false-positive results in newborn screening has been described for various screening programs [3], [5], [6], [7], [8]. Only two of these studies were controlled.…”

Section: Introductionmentioning

confidence: 99%

Parental knowledge reduces long term anxiety induced by false-positive test results after newborn screening for cystic fibrosis

Langen

Pal²,

Reijntjens

et al. 2014

Molecular Genetics and Metabolism Reports

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BackgroundFalse-positive screening results in newborn screening for cystic fibrosis may lead to parental stress, family relationship problems and a changed perception of the child's health.Aim of the studyTo evaluate whether parental anxiety induced by a false positive screening result disappears after six months and to assess whether a special program to inform parents prior and during the screening procedure prevents or diminishes parental anxiety.MethodsProspective controlled study assessing the long term effects of false-positive test results of newborn screening for cystic fibrosis (NBSCF) on parental anxiety and stress by means of questionnaires sent to parents of 106 infants with a false positive newborn screening test and 318 randomly selected infants with a true negative screening test. Additionally we interviewed 25 parents of the false-positive group.ResultsParents showed negative feelings after being informed about the positive screening test result. After confirmation that their child was healthy and not suffering from CF, most parents felt reassured. After six months no difference in anxiety levels between both groups of parents was found. Well-informed parents in the false positive group experienced less stress.ConclusionsA positive screening test result induces parental anxiety but false positive test results in NBSCF do not seem to cause long-term anxiety. Well-informed parents show lower stress and anxiety levels.

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Examination of long-lasting parental concern after false-positive results of neonatal hearing screening

Abstract: False-positive UNHS test results do not cause long-term general parental anxiety. However, 6 months after screening, a considerable proportion of parents continued to experience hearing-specific worries regarding their child.

Cited by 22 publications

References 26 publications

Nationwide population genetic screening improves outcomes of newborn screening for hearing loss in China

Nationwide population genetic screening improves outcomes of newborn screening for hearing loss in China

Anxiety of the mothers with referred baby during Universal Newborn Hearing Screening

Parental knowledge reduces long term anxiety induced by false-positive test results after newborn screening for cystic fibrosis

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