Examination of optical coherence tomography findings in patients with methamphetamine use disorder

Demir, Bahadır; Özsoy, Filiz; Kepenek, Idris; Altındağ, Abdurrahman

doi:10.1080/10550887.2021.1983294

Cited by 2 publications

(7 citation statements)

References 22 publications

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“…In another study, it was observed that there was thinning in certain quadrants of the macula [ 26 ]. In addition, in another study conducted in our country, no differences were found in terms of macular thickness between patients with MUD and healthy controls [ 16 ]. Our results were similar to those of that study (macular thickness did not differ in any quadrant between controls and patients with MUD).…”

Section: Discussionmentioning

confidence: 96%

“…With this similarity in its development, it is considered that a change in brain function may be reflected in the retina [ 21 ]. With this mechanism in mind, studies conducted with OCT in individuals with psychiatric diseases have gained momentum in recent years [ 10 , 12 , 13 , 14 , 15 , 16 ]. However, a slightly more limited number of papers have studied addiction and OCT measurements.…”

Section: Discussionmentioning

confidence: 99%

“…However, a slightly more limited number of papers have studied addiction and OCT measurements. The results reported are contradictory [ 15 , 16 , 22 , 23 , 24 , 25 ]. In a study in which OCT measurements were measured in patients with alcohol use disorder, RNLF thicknesses were not different from those of healthy controls [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…In one of the other studies that were conducted with MUD patients, no difference was detected between patients and healthy controls. In one patient group, minimal thinning was found in the superior and temporal quadrants [ 16 , 26 ]. In an animal study that considered three groups of mice (mice injected with a high or low dose of methamphetamine, as well as healthy mice), it was shown that increased chemokines resulted in damage to the retina in the mouse group injected with high-dose methamphetamine [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…As for psychiatric diseases, a relationship was detected between neural degeneration in the retina layer of patients with schizophrenia and the severity of the disease, findings which were then also identified in patients with major depressive disorder and obsessive-compulsive disorder [ 10 , 14 ]. There are very few studies reporting retinal neural loss using OCT in methamphetamine use disorder [ 15 , 16 ]. For this reason, the purpose of the present study was to compare the RNLF, MMT, and CMT measurements of patients diagnosed with methamphetamine use disorder with those of healthy controls by using OCT, in an effort to contribute to the data in the literature.…”

Section: Introductionmentioning

confidence: 99%

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OCT Findings in Patients with Methamphetamine Use Disorder

Kaya

Kaya²

2023

JPM

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Purpose: In the present study, the purpose was to examine the results of optical coherence tomography (OCT) measurements in patients diagnosed with methamphetamine use disorder (MUD) by comparing them with healthy controls. Materials and Methods: A total of 114 eyes were evaluated in this study (27 patients and 30 control group participants). After detailed biomicroscopic examinations of all participants by the same ophthalmologist, both eyes were evaluated by OCT. The retinal nerve fiber layer thickness (RNFL) and macular thickness were calculated from OCT. Results: No statistically significant differences were detected between the demographic data of the patient and control groups (p > 0.05). When OCT findings were evaluated, macular thickness and volume were not different between the groups (p > 0.05). With respect to RNFL, the left eye superior, inferior, temporal, and nasal quadrants, as well as the left eye’s total measurements were found to be thicker than those of controls (p < 0.05). In both eyes, the left eye nasal quadrant and APIS total score were negatively correlated, the total RNLF measurement of the right eye and APIS motivation subscale score were negatively correlated, central macular thickness and the APIS motivation subscale score were positively correlated, and the APIS substance use characteristics subscale score and left eye temporal quadrant RNLF measurement were positively correlated. Conclusion: Our study is the first to evaluate addiction severity and OCT findings in MUD. However, this study needs to be supported by further studies so that OCT findings, which can be used as an effective method for demonstrating possible neurodegeneration in methamphetamine use disorder, gain importance.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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OCT Findings in Patients with Methamphetamine Use Disorder

Kaya

Kaya²

2023

JPM

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Degenerative brain changes associated with tramadol use: an optical coherence tomography study

Khalil,

Esmael

et al. 2023

Middle East Curr Psychiatry

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Background Tramadol—a synthetic opioid originally used as an analgesic—has been widely misused as an addictive drug in the middle east in the last twenty years. Brain changes associated with long-term tramadol use are understudied. This study aimed to detect the possible effects of tramadol use for at least one year on the brain. Optical coherence tomography (OCT) as a noninvasive measure can assess changes in retinal thickness which reflects degenerative changes in the brain. Methods Twenty-five patients fulfilling the tramadol use disorder according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) criteria were compared to 25 matched control subjects free of substance use disorders. Other psychiatric and medical conditions that may affect OCT were excluded from both groups. Patients were assessed using Addiction Severity Index; meanwhile, both groups were evaluated using OCT. Results Patients with tramadol use showed a lower thickness of most OCT parameters than healthy non-tramadol controls. The retinal nerve fiber layer (RNFL) thickness was not associated with tramadol dose, duration of use, or the age of first use. There were differences between the right and left eyes in RNFL and Ganglion cell complex (GCC) thickness. Conclusions Long-term tramadol use is associated with decreased thickness of RNFL that can be a potential marker and an early sign for degeneration detected by noninvasive techniques like OCT.

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Examination of optical coherence tomography findings in patients with methamphetamine use disorder

Cited by 2 publications

References 22 publications

OCT Findings in Patients with Methamphetamine Use Disorder

OCT Findings in Patients with Methamphetamine Use Disorder

Degenerative brain changes associated with tramadol use: an optical coherence tomography study

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