Hemangiomas are common benign vascular anomalies that can occur in various locations throughout the body, including the oral cavity. The lesions are generally asymptomatic and exhibit a variation in the size and colour. Here, we present a case report of a hemangioma located in the buccal mucosa of a 40-year-old female patient who presented with asymptomatic reddish purplish swellings in the buccal mucosa, which had gradually increased in size over the last 6 months. Clinical examination and imaging studies confirmed the diagnosis of a hemangioma. 1 ml of 3% of sclerosing agent (sterol; sodium tetradecyl sulphate) mixed with lignocaine HCL was injected in the periphery of the lesion, once a week for 3 weeks, and periodic follow-up evaluation revealed a marked reduction in the lesion size. This case demonstrates the feasibility and efficacy of sclerotherapy as a minimally invasive treatment option for hemangiomas of the buccal mucosa, particularly in cases where surgical excision may be technically challenging or associated with significant morbidity.