In this study, the effects of the characteristics of droplets of water spray on suppression of fire were analyzed numerically using fire dynamics simulator (FDS) 6.5.2. Additionally, the fire suppression characteristics by the water spray nozzle, including the extinguishing coefficient (EC), droplet size distribution function (SDF), median volumetric diameter (MVD), and droplets per second (DPS), were evaluated in terms of the decreasing normalized heat release rate (HRR) curve and cooling time. It was observed that with increase in the EC, the normalized HRR curve decreased rapidly, and the changing MVD affected the suppression of fire. In case of mono-disperse, the normalized HRR curve decreased slowly with the increase in DPS. On the contrary, in case of multi-disperse, the normalized HRR curve decreased rapidly even with a small increase in DPS.