2021
DOI: 10.3390/v13061084
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Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses

Abstract: The transmission of viruses from animal hosts into humans have led to the emergence of several diseases. Usually these cross-species transmissions are blocked by host restriction factors, which are proteins that can block virus replication at a specific step. In the natural virus host, the restriction factor activity is usually suppressed by a viral antagonist protein, but this is not the case for restriction factors from an unnatural host. However, due to ongoing viral evolution, sometimes the viral antagonis… Show more

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Cited by 21 publications
(35 citation statements)
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References 170 publications
(284 reference statements)
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“…The evolutionary pressure that restriction factors and antagonists have exerted on each other resulted in further adaptations at the virus-host interface. Thus, restriction factors are often less effective against viral infections of their natural host but constitute potent barriers to cross-species infections [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…The evolutionary pressure that restriction factors and antagonists have exerted on each other resulted in further adaptations at the virus-host interface. Thus, restriction factors are often less effective against viral infections of their natural host but constitute potent barriers to cross-species infections [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…The apolipoprotein B mRNA editing enzyme, catalytic polypeptide (APOBEC) enzyme family in humans has 11 members with diverse functions in metabolism and immunity [ 1 , 2 , 3 , 4 ]. The enzymes deaminate cytosine in RNA or single-stranded (ss) DNA, which forms uracil.…”
mentioning
confidence: 99%
“…To inhibit HIV, the APOBEC3 enzymes must become encapsidated into the budding virion [ 2 , 3 , 12 ]. This enables access to the viral genome and newly synthesized (-) DNA during reverse transcription.…”
mentioning
confidence: 99%
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