Examination of the Best Pressure Range for Ion/Molecule Reactions of Anthraquinones in an External Source Ion Trap Mass Spectrometer

Wu, Hui‐Fen; Chen, Chien‐Hung; Ho, Ming‐Yi

doi:10.2116/analsci.17.515

Cited by 15 publications

(8 citation statements)

References 27 publications

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“…Scheme 10 illustrates an interesting example with vincamine where the CH 3 OCH 2 þ ion formally abstracts HO À from the substrate via addition and sequential loses of CH 3 OH and CH 2 =O. Wu and co-workers (Wu & Lin, 2000;Wu & Ho, 2001;Wu, Chen, & Ho, 2001a;Wu, Chen, & Chen, 2001b) also have employed an ion trap to investigate the reactions of ions derived from dimethyl ether ionization. Using a Finnigan GCQ, relatively non-volatile analytes, anthraquinone derivatives, were introduced via a heated direct insertion probe and led to the formation of typical products (i.e., CH 3 OCH 2 þ , CH 3 þ , and CH þ addition) in their reactions with SCHEME 7.…”

Section: Chemical Ionization and Related Workmentioning

confidence: 99%

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Quadrupole ion trap studies of fundamental organic reactions

Gronert

2004

Mass Spectrometry Reviews

128

133

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Over the past several decades, quadrupole ion traps have become important instruments in the study of gas phase ion/molecule reactions. As a part of this work, they have been employed in a number of studies focused on fundamental organic reaction mechanisms. In this review, the general features and limitations of quadrupole ion traps are discussed followed by a description of representative ion trap studies of organic reaction mechanisms such as substitution, elimination, and acyl transfer reactions.

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Section: Chemical Ionization and Related Workmentioning

confidence: 99%

“…the methoxymethyl cation (Wu, Chen, & Ho, 2001a;Wu, Chen, & Chen, 2001b). The mechanisms for forming these types of products have been studied in detail in other instruments (Freitas & O'Hair, 1998).…”

Section: Quadrupole Ion Trap Studies Of Fundamental Organic Reactionsmentioning

confidence: 99%

Quadrupole ion trap studies of fundamental organic reactions

Gronert

2004

Mass Spectrometry Reviews

128

133

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“…In addition to sodium ion, chloride ion, silver ion or silicon ion participate in the formation of adduct ion in TOF-SIMS. Many papers (Donovan and Brodbelt 1992;Iida et al 1993;Wu et al 2001) have reported that adduct ions such as [M+13] + ion and [M+15] + ion, which are considered to be formed by methylene substitution and methyl-cation attachment, respectively, are generated in chemical ionization mass spectrometry such as electron spray ionization mass spectrometry. The m/z 301 ion generated from ferruginol by TOF-SIMS corresponds to [M+15] + ion, and is considered to be an adduct ion formed by methyl-cation attachment.…”

Section: Discussionmentioning

confidence: 99%

Localization of ferruginol, a diterpene phenol, in Cryptomeria japonica heartwood by time-of-flight secondary ion mass spectrometry

Imai

Tanabe

Kato

et al. 2005

Planta

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Time-of-flight secondary ion mass spectrometry (TOF-SIMS) was applied to the investigation of heartwood extractives in Sugi (Cryptomeria japonica). Sugi heartwood tissue generated secondary ions that were not produced from sapwood tissue by TOF-SIMS. Among the peculiar ions generated from heartwood, two positive ions of m/z 285 and 301 were remarkable due to their appearance in a larger mass range and with a high intensity. These two ions were not generated from heartwood tissue preextracted with n-hexane, and the nhexane extract of Sugi heartwood produced both ions. Gas chromatography-mass spectrometry of the n-hexane extract demonstrated that ferruginol, a diterpene phenol, the molecular weight of which is 286, constituted one of the predominant constituents of the extract. Authentic ferruginol also generated both ions by TOF-SIMS. The molecular formula of the m/z 285 ion generated from Sugi heartwood tissue was estimated to be C 20 H 29 O, which corresponds well with that of ferruginol, i.e. C 20 H 30 O, by peak identification. All these results strongly suggest that the m/z 285 ion generated from Sugi heartwood tissue originated significantly from ferruginol in Sugi heartwood. By TOF-SIMS imaging, the m/z 285 ion was detected uniformly in the tracheid cell walls, in the cell walls of the axial parenchyma cells and ray parenchyma cells, and also inside these parenchyma cells. These results indicate that ferruginol was distributed almost evenly in Sugi heartwood tissue.

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“…All experiments were conducted in an external source ion trap mass spectrometer (Finnigan MAT GCQ) 22–26. Dimethyl ether was used as the reagent gas, with its pressure controlled at 8 × 10 − 4 Torr.…”

Section: Methodsmentioning

confidence: 99%

“…However, all these works were performed in a traditional internal ionization ITMS. In 1996, the Finnigan MAT Company began to produce a new bench‐top ion trap with an external CI source (GCQ) 22–26. Previous works have revealed the excellent sensitivity of the MS/MS capability in the external source ion trap mass spectrometer for the studies of dopamine and adrenaline with dimethyl ether 22,.…”

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confidence: 99%

Probing reactive sites for ion‐molecule reactions of anthraquinones with dimethyl ether using an external source ion trap tandem mass spectrometer and computational chemistry

Chen

2001

Rapid Comm Mass Spectrometry

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Gas-phase ion-molecule reactions of anthraquinone derivatives with dimethyl ether (DME) were investigated using an external source ion trap mass spectrometer. Semi-empirical calculations were executed to determine possible reactive sites for the product ions. Collision activated dissociation (CAD) was successfully performed for very low abundance of ion-molecule products. Even for product ions with a relative intensity below 1%, CAD experiments can be successfully performed. Significantly more structural information could be elucidated based on this special feature. Importantly, the CAD spectra of very minor ions could be measured by this ion trap instrument, which significantly enhances the future role of the ion trap as a powerful analytical instrument. CAD of all product ions on anthraquinone compounds typically eliminates neutral molecules such as CO or H(2)O. A hydration phenomenon in the CAD processes resulting from the precursor ions incorporating one molecule of H(2)O and then eliminating one molecule of CO was observed in this study.

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Examination of the Best Pressure Range for Ion/Molecule Reactions of Anthraquinones in an External Source Ion Trap Mass Spectrometer

Cited by 15 publications

References 27 publications

Quadrupole ion trap studies of fundamental organic reactions

Quadrupole ion trap studies of fundamental organic reactions

Localization of ferruginol, a diterpene phenol, in Cryptomeria japonica heartwood by time-of-flight secondary ion mass spectrometry

Probing reactive sites for ion‐molecule reactions of anthraquinones with dimethyl ether using an external source ion trap tandem mass spectrometer and computational chemistry

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