Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix‐assisted laser desorption/ionisation mass spectrometry

Atkinson, Sally; Loadman, Paul M.; Sutton, Chris W.; Patterson, Laurence H.; Clench, Malcolm R.

doi:10.1002/rcm.2952

Cited by 83 publications

(64 citation statements)

References 16 publications

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“…For small molecules analysis, two main classes may be distinguished -exogenous drugs and endogenous metabolites. Exogenous drugs have been studied in MALDI-MSI far later than proteins (since 2004) for different targets such as olanzapine (antipsychotic) [85][86][87], imatinib [87], vinblastine [88], and banoxantrone [89] (cancer drugs). Among endogenous metabolites, lipids such as glycerophospholipids and glycosphingolipids or simple lipids like cholesterol, diacylglycerols, or triacylglycerols have been extensively investigated [90].…”

Section: Maldi Mass Spectrometry Imagingmentioning

confidence: 99%

MALDI In-Source Decay, from Sequencing to Imaging

Debois

Smargiasso

Demeure

et al. 2012

Topics in Current Chemistry

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Matrix-assisted laser desorption/ionization (MALDI) is now a mature method allowing the identification and, more challenging, the quantification of biopolymers (proteins, nucleic acids, glycans, etc). MALDI spectra show mostly intact singly charged ions. To obtain fragments, the activation of singly charged precursors is necessary, but not efficient above 3.5 kDa, thus making MALDI MS/MS difficult for large species. In-source decay (ISD) is a prompt fragmentation reaction that can be induced thermally or by radicals. As fragments are formed in the source, precursor ions cannot be selected; however, the technique is not limited by the mass of the analyzed compounds and pseudo MS3 can be performed on intense fragments. The discovery of new matrices that enhance the ISD yield, combined with the high sensitivity of MALDI mass spectrometers, and software development, opens new perspectives. We first review the mechanisms involved in the ISD processes, then discuss ISD applications like top-down sequencing and post-translational modifications (PTMs) studies, and finally review MALDI-ISD tissue imaging applications.

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Section: Maldi Mass Spectrometry Imagingmentioning

confidence: 99%

MALDI In-Source Decay, from Sequencing to Imaging

Debois

Smargiasso

Demeure

et al. 2012

Topics in Current Chemistry

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“…To complement the disadvantage of WBA, MALDI-IMS and WBA have recently been used together. The combination of MALDI-IMS and WBA makes it possible to obtain more reliable data for absorption, distribution, metabolism, and excretion of drugs (Atkinson et al, 2007;Caprioli et al, 2008;Clench et al, 2008;Stoeckli et al, 2006). The application of MALDI-IMS to pharmacokinetics in a whole-body mouse section was first reported by Rohner et al in 2005(Rohner et al, 2005.…”

Section: Ims For Exogenous Drugsmentioning

confidence: 99%

Application of Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Zaima¹

2012

Pharmacology

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“…In fact, some advanced researches of pharmacokinetics have already been reported (Atkinson et al 2007;Stoeckli et al 2006). Furthermore, since IMS provides us with various quantitative information as well as positional information, it will be applied not only to the biomedical field but also to the biophysical field in the future.…”

Section: Future Perspectivementioning

confidence: 99%

Imaging mass spectrometry: principle and application

2009

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Imaging mass spectrometry (IMS) is twodimensional mass spectrometry to visualize the spatial distribution of biomolecules, which does not need either separation or purification of target molecules, and enables us to monitor not only the identification of unknown molecules but also the localization of numerous molecules simultaneously. Among the ionization techniques, matrix assisted laser desorption/ionization (MALDI) is one of the most generally used for IMS, which allows the analysis of numerous biomolecules ranging over wide molecular weights. Proper selection and preparation of matrix is essential for successful imaging using IMS. Tandem mass spectrometry, which is referred to MS n , enables the structural analysis of a molecule detected by the first step of IMS. Applications of IMS were initially developed for studying proteins or peptides. At present, however, targets of IMS research have expanded to the imaging of small endogenous metabolites such as lipids, exogenous drug pharmacokinetics, exploring new disease markers, and other new scientific fields. We hope that this new technology will open a new era for biophysics.

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Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix‐assisted laser desorption/ionisation mass spectrometry

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Cited by 83 publications

References 16 publications

MALDI In-Source Decay, from Sequencing to Imaging

MALDI In-Source Decay, from Sequencing to Imaging

Application of Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Imaging mass spectrometry: principle and application

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