Examination of the Patient with Head and Neck Cancer

Georgopoulos, Rachel; Liu, Jeffrey

doi:10.1016/j.soc.2015.03.003

Cited by 11 publications

(8 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Staging oral and maxillofacial cancers in human and animal patients is crucial in creating a treatment plan for surgery and adjunctive treatment modalities. 1 Staging these neoplasms has been described by the World Health Organization and is currently the standard used in both human and veterinary medicine. The staging protocol includes the extent of the primary tumor (T), the status of the regional lymph nodes (N), and the presence or absence of distant metastasis (M).…”

Section: Introductionmentioning

confidence: 99%

Validation of Regional Lymph Node Excisional Biopsy for Staging Oral and Maxillofacial Malignant Neoplasms in 97 Dogs and 10 Cats (2006-2016)

2019

View full text Add to dashboard Cite

The objective of this retrospective clinical study was to confirm the validity of excisional biopsy of regional lymphocentrums for staging oral and maxillofacial neoplasms in a population of 97 dogs and 10 cats. Patients diagnosed with oral and maxillofacial malignant neoplasms underwent ipsilateral excisional biopsy of the mandibular, parotid, and medial retropharyngeal lymphocentrums that receive afferent drainage from the oral and maxillofacial region followed by curative intent surgery of the neoplasm. Biopsy specimens and the resected neoplasm were submitted to a commercial pathology laboratory for histopathologic assessment. The incidence of metastasis to one or more regional lymphocentrums was 14.0%. Of the cases with metastatic disease, 26.7% did not involve the mandibular lymphocentrum. Although the incidence of regional lymph node metastasis was less than reported previously, regional lymph node assessment is warranted in cases of oral and maxillofacial neoplasia.

show abstract

Section: Introductionmentioning

confidence: 99%

Validation of Regional Lymph Node Excisional Biopsy for Staging Oral and Maxillofacial Malignant Neoplasms in 97 Dogs and 10 Cats (2006-2016)

2019

View full text Add to dashboard Cite

show abstract

“…Because NCI‐CTC oral mucositis grading scale is mentioned as the most commonly used scale for assessing oral mucositis in researches (Common Terminology Criteria for Adverse Events V4.0 (CTCAE), ; Georgopoulos and Liu, ), we chose this scale in current study. Moreover, for better evaluation based on both subjective and objective criteria, we also selected WHO grading scale for use in this research.…”

Section: Discussionmentioning

confidence: 99%

Effect of Oral Silymarin Administration on Prevention of Radiotherapy Induced Mucositis: A Randomized, Double‐Blinded, Placebo‐Controlled Clinical Trial

Elyasi

Hosseini

Moghadam

et al. 2016

Phytotherapy Research

View full text Add to dashboard Cite

Mucositis is a frequent severe complication of radiation therapy in patient with head and neck cancer. Silymarin is a polyphenolic flavonoid extracted from the milk thistle that exhibits strong antioxidant and antiinflammatory activities. In this study, we evaluate silymarin efficacy in prevention of radiotherapy induced mucositis in patients with head and neck cancer, as the first human study. During this pilot, randomized, double-blinded, placebo-controlled clinical trial, the effect of oral silymarin 420 mg daily in three divided doses starting at the first day of radiotherapy for 6 weeks, on oral mucositis occurrence was assessed. Twenty-seven patients fulfilled the inclusion criteria assigned to the silymarin or placebo group. World Health Organization and National Cancer Institute-Common Terminology Criteria oral mucositis grading scale scores were recorded at baseline and weekly during these 6 weeks. The median World Health Organization and National Cancer Institute Common Terminology Criteria scores were significantly lower in silymarin group at the end of the first to sixth week (p < 0.05). The scores increased significantly in both placebo and silymarin groups during radiotherapy, but there was a delay for mucositis development and progression in silymarin group. Prophylactic administration of conventional form of silymarin tablets could significantly reduce the severity of radiotherapy induced mucositis and delay its occurrence in patients with head and neck cancer. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

“…On the other hand, MRI offers superior soft-tissue resolution and allows assessing bone-marrow signal abnormalities, intracranial extension and perineural spread. 4 In the examination of patients with head and neck cancer, flexible fibre-optic laryngoscopy (FFL) is one of the modalities used to evaluate the nasal cavity, nasopharynx, oropharynx, hypopharynx and larynx. This technique permits evaluation of normal anatomy and functionality of the larynx.…”

Section: Introductionmentioning

confidence: 99%

“…5 Some disadvantages of this procedure include that it is invasive, it requires specialist equipment and it depends on the operator’s experience. 4 In addition, this procedure fails in cases of stenosis or obstruction, 6 and in some cases it does not allow the assessment of the subglottis and upper trachea. 4…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of diagnostic accuracy of computed tomography virtual endoscopy and flexible fibre-optic laryngoscopy in the evaluation of neck anatomic structures and neoplasms

et al. 2020

View full text Add to dashboard Cite

Background and purpose Computed tomography virtual endoscopy (CT-VE) is a non-invasive technique which allows visualisation of intraluminal surfaces by tridimensional reconstruction of air/soft tissues. The aim of this study was to compare the diagnostic accuracy of CT-VE and flexible fibre-optic laryngoscopy (FFL) in identifying normal neck anatomic structures and pharyngeal and laryngeal lesions. Methods Forty-two patients with a history of neck cancer were assessed by two ENT surgeons using FFL and by one neuroradiologist using CT-VE in order to evaluate the visualisation of the epiglottis, vallecula, glossoepiglottic folds, pyriform sinuses, vocal cords and mass pathology. The visualisation of the structures in both modalities was assessed according to the following score: 0 = not visualised, 1 = partial visualisation, 2 = complete and clear visualisation. A weighted kappa coefficient was used to evaluate the inter-observer agreement. McNemar’s test was performed to compare the two diagnostic tests. Results The inter-observer agreement between FFL and CT-VE was fair in the assessment of the vocal cords ( k = 0.341); moderate in the assessment of the glossoepiglottic folds ( k = 0.418), epiglottis ( k = 0.513) and pyriform sinuses ( k = 0.477); and substantial in the assessment of the vallecula ( k = 0.618) and the tumour (0.740). McNemar’s test showed no significant difference between the two tests ( p<0.05). Conclusion CT-VE is a non-invasive technique with a diagnostic accuracy comparable to FFL in terms of visualisation of anatomical structures and pharyngeal and laryngeal lesions.

show abstract

Examination of the Patient with Head and Neck Cancer

Cited by 11 publications

References 51 publications

Validation of Regional Lymph Node Excisional Biopsy for Staging Oral and Maxillofacial Malignant Neoplasms in 97 Dogs and 10 Cats (2006-2016)

Validation of Regional Lymph Node Excisional Biopsy for Staging Oral and Maxillofacial Malignant Neoplasms in 97 Dogs and 10 Cats (2006-2016)

Effect of Oral Silymarin Administration on Prevention of Radiotherapy Induced Mucositis: A Randomized, Double‐Blinded, Placebo‐Controlled Clinical Trial

Comparison of diagnostic accuracy of computed tomography virtual endoscopy and flexible fibre-optic laryngoscopy in the evaluation of neck anatomic structures and neoplasms

Contact Info

Product

Resources

About