Examination of the Pharmacology of Oxytocin and Clinical Guidelines for Use in Labor

Page, Katie; McCool, William F.; Guidera, Mamie

doi:10.1111/jmwh.12610

Cited by 52 publications

(46 citation statements)

References 48 publications

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“…Oxytocin known for its role in labor and lactation is generally used in clinical practice for the induction and augmentation of labor ( 60 ). However, recent investigations in animals evidenced a pivotal role of OTX in the regulation of a central inflammatory response ( 61 – 63 ).…”

Section: Relation Between Otx and The Immune System: Evidences Of An mentioning

confidence: 99%

Modulating the Oxytocin System During the Perinatal Period: A New Strategy for Neuroprotection of the Immature Brain?

et al. 2018

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Oxytocin is a neurohypophysal hormone known for its activity during labor and its role in lactation. However, the function of oxytocin (OTX) goes far beyond the peripheral regulation of reproduction, and the central effects of OTX have been extensively investigated, since it has been recognized to influence the learning and memory processes. OTX has also prominent effects on social behavior, anxiety, and autism. Interaction between glucocorticoids, OTX, and maternal behavior may have long-term effects on the developmental program of the developing brain subjected to adverse events during pre and perinatal periods. OTX treatment in humans improves many aspects of social cognition and behavior. Its effects on the hypothalamic–pituitary–adrenal axis and inflammation appear to be of interest in neonates because these properties may confer benefits when the perinatal brain has been subjected to injury. Indeed, early life inflammation and abnormal adrenal response to stress have been associated with an abnormal white matter development. Recent investigations demonstrated that OTX is involved in the modulation of microglial reactivity in the developing brain. This review recapitulates state-of-the art data supporting the hypothesis that the OTX system could be considered as an innovative candidate for neuroprotection, especially in the immature brain.

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Section: Relation Between Otx and The Immune System: Evidences Of An mentioning

confidence: 99%

Modulating the Oxytocin System During the Perinatal Period: A New Strategy for Neuroprotection of the Immature Brain?

et al. 2018

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“…Jahrhunderts als Hypophysenextrakt genutzt. Aber erst die synthetische Herstellung durch Vigneaud und Kollegen in den 50er Jahren des vorherigen Jahrhunderts, führte zu seiner festen Etablierung in der Geburtshilfe [27]. Verschiedene Analysen unter Erstgebärenden in den USA ergaben, dass der Oxytocingebrauch zur Einleitung oder Wehenunterstützung zwischen 37 und 75 % lag [16].…”

Section: Synthetisches Oxytocinunclassified

“…Zieht man davon die primären Sectiones ab, erhielten sogar mehr als ein Drittel aller Gebärenden Oxytocin zur Wehenunterstützung [3]. [27].…”

Section: Synthetisches Oxytocinunclassified

“…Zusätzlich konnte durch Dopplerflussmessungen bei oxytocinunterstützer Wehentätigkeit ein erhöhter Widerstand der A. uterina im Vergleich zu physiologischen Wehen gemessen werden [27]. Dies muss insbesondere in der AP beachtet werden, wenn Oxytocin zur Geburtsbeschleunigung bei pathologischem CTG eingesetzt und durch das Medikament gleichzeitig die fetale Oxygenierung verschlechtert wird.…”

Section: Nebenwirkungen Von Oxytocinunclassified

“…Weitere Nebenwirkungen wie z. B. eine Hyponatriämie oder eine Hypotonie hängen mit der vasopressinähnlichen Struktur des Oxytocins und mit der Wirkung an der glatten Muskulatur zusammen [27].…”

Section: Nebenwirkungen Von Oxytocinunclassified

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Oxytocin bei der Geburt – wann und wie viel?

Filsinger¹

2019

Hebamme

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Das Medikament Oxytocin wird in der Geburtshilfe bei protrahiertem Geburtsverlauf präventiv eingesetzt, um maternaler und fetaler Morbidität vorzubeugen. Vor jedem Einsatz müssen individuell die positiven Effekte und die vielfältigen potenziellen Nebenwirkungen abgewogen werden. Die Autorin plädiert für interprofessionell entwickelte klinikinterne Standards, auf die das geburtshilfliche Team regelmäßig geschult wird. Ziel ist es, Betreuungskonzepte für Frauen in der Latenzphase zu entwickeln, um den unnötigen Einsatz von Oxytocin zu vermeiden.

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“Blind men and an elephant”: The need for animals in research, drug safety studies, and understanding civilizational diseases

Anbalagan

2023

Anim Models and Exp Med

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Animal‐based research and drug safety studies are essential to understanding the mysteries of nature and the long‐term survival of humans. Due to the rapid increase in the global human population, conflict‐ and economically driven human migration, tourism‐related activities, densely populated metropolitan areas, and local policies, humans will be affected by a multitude of novel disease‐causing microorganisms and civilizational diseases. Despite disparities among countries, recent and planned changes in regulations concerning animal research and drug safety studies could have detrimental effects on both the animal research community and nations lacking sufficient social support systems. Based on existing scientific literature, I argue that we need animal research encompassing aspects such as animal development, behavior, drug safety studies, and for the understanding of future civilizational diseases. Depending on the nature of the research questions and local challenges, a suitable animal model organism should be made mandatory.

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Examination of the Pharmacology of Oxytocin and Clinical Guidelines for Use in Labor

Cited by 52 publications

References 48 publications

Modulating the Oxytocin System During the Perinatal Period: A New Strategy for Neuroprotection of the Immature Brain?

Modulating the Oxytocin System During the Perinatal Period: A New Strategy for Neuroprotection of the Immature Brain?

Oxytocin bei der Geburt – wann und wie viel?

“Blind men and an elephant”: The need for animals in research, drug safety studies, and understanding civilizational diseases

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