This electronic do This study aims to analyze the effect of the Technological Pedagogical Content Knowledge (TPCK) learning model through online learning on the learning outcomes, effectiveness and competencies of 21st century students and teachers after Covid-19. This research is a type of meta-analysis research. This research sample comes from national and international journals that have been published from 2017-2022. Sample search through journal databases accessed through Google Scholar, Eric journal, Emerald, Elsevier, Sage Journal, Taylor and Francis and IEEE. The data selection technique in this study was through purposive sampling technique. The data that was sampled was in accordance with the criteria or related to TPCK in science learning on the variables of effectiveness and student learning outcomes. The data analysis used is quantitative data analysis with the help of SPSS version 16 application by looking at the value of N-gain and Effect size (ES). The results of this study concluded that the Technological Pedagogical Content Knowledge (TPCK) learning model through online learning had a significant effect on student learning outcomes with an average value of 70.5, student learning effectiveness with an average of 73 with an N-gain of 0.61, and 21st century competence of students and Teachers obtained an average of 77.33 with an effect size of 0.48 with moderate criteria