Examination stress, platelet peripheral benzodiazepine binding sites, and plasma hormone levels

Karp, Leon; Weizman, Abraham; Tyano, Sam; Gavish, Moshe

doi:10.1016/0024-3205(89)90334-2

Cited by 44 publications

(13 citation statements)

References 21 publications

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“…Stressing situations, such as that of sitting for an exam [23] or a parachute-training course [24] influence the density of the receptors, in the sense that an acute stress seems to provoke an up-regulation, while a repeated stress provokes a down-regulation. There exists also a growing literature on the study of these receptors in some neuropsychiatric conditions, such as generalized anxiety disorder, obsessive-compulsive disorder and Alz heimer's disease [25][26][27],…”

Section: Introductionmentioning

confidence: 99%

Changes in Peripheral Benzodiazepine Receptors in Patients with Panic Disorder and Obsessive-Compulsive Disorder

Marazziti¹,

Rotondo²,

Martini

et al. 1994

Neuropsychobiology

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Peripheral benzodiazepine (BDZ) receptors were investigated through the binding of the specific ligand ³H-PK-11195 to platelet membranes, in 17 patients suffering from panic disorder (PD) and in 16 patients affected by obsessive-compulsive disorder (OCD). The results, showing that the density (Bmax) of peripheral BDZ receptors was significantly lower in patients with PD than in controls or OC patients, suggest that the number of platelet BDZ receptors varies with different anxiety disorders and that perhaps this marker may be beneficial in differentiating some subtypes of these disorders.

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Section: Introductionmentioning

confidence: 99%

Changes in Peripheral Benzodiazepine Receptors in Patients with Panic Disorder and Obsessive-Compulsive Disorder

Marazziti¹,

Rotondo²,

Martini

et al. 1994

Neuropsychobiology

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“…Ten days after the stress there was a 15% decrease in PBR density in the stressed residents, but their values remained 29% higher than the controls. The authors also examined plasma levels of cortisol, growth hormone, and prolactin and found no differences between stressed residents and controls (67).…”

Section: Peripheral Benzodiazepine Receptorsmentioning

confidence: 97%

Searching for the Biological Pathways Between Stress and Health

Kelly

Hertzman

Daniel

1997

Annu. Rev. Public Health

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Population-based, person-specific health surveys, with concomitant biological measures, should provide important information about the processes by which socioeconomic and psychosocial factors embed themselves in human health. Questionnaire responses allow for assessment of the perceived psychosocial environment, but biological measurements will measure the status of the psychoneuroimmunology/psychoneuroendocrinology (PNI/PNE) pathways and may allow us to identify people who have "adapted" to their stress because of experience, expectations, stoicism, etc. This review sets criteria to evaluate potential physiological markers of chronic stress. Because population health surveys involve a massive number of samples, special consideration must be given to the laboratory analysis method and transportation time of the markers chosen. We reviewed five areas: glycosylated proteins, the immune system, hemostasis, peripheral benzodiazepine receptors, and the waist-hip ratio.

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“…It appears that PBRs are sensitive to hormonal changes , Basile et al 1985, Gavish et al 1986a and to stress and anxiety (Drugan et al 1986, Weizman et al 1987a, Karp et al 1989. A recent report indicates that PBRs play a role in steroidogenesis (Papadopoulos et al 1991).…”

Section: Introductionmentioning

confidence: 94%

"Peripheral" Benzodiazepine Receptor Density Is Not Altered by Methylphenidate Treatment in Children with Attention-Deficit Hyperactivity Disorder

Weizman¹,

Dar²,

Landa³

et al. 1993

Journal of Child and Adolescent Psychopharmacology

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"Peripheral" benzodiazepine receptors (PBRs) are located in the central nervous system and the periphery, are involved in the release of dopamine, and are sensitive to agents active at the dopaminergic system. Because attention-deficit hyperactivity disorder (ADHD) is related to dysregulation of dopaminergic neurotransmission, and because benzodiazepines can potentially aggravate the symptoms of ADHD, we have assessed the possible involvement of PBRs in the pathophysiology and pharmacotherapy of ADHD. [(3)H]PK 11195 was used to label platelet PBRs. Platelet PBRs were measured in eight ADHD boys (aged 9-15 years) before and after 4 weeks of treatment with methylphenidate 10-20 mg/day. ADHD patients before treatment did not differ from age-matched healthy controls in [(3)H]PK 11195 binding values. Four weeks of methylphenidate treatment did not significantly affect platelet PBR density in children with ADHD, despite the beneficial clinical effects. These results do not support the involvement of the PBRs in the pathophysiology of ADHD or in the therapeutic effects of methylphenidate.

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Examination stress, platelet peripheral benzodiazepine binding sites, and plasma hormone levels

Cited by 44 publications

References 21 publications

Changes in Peripheral Benzodiazepine Receptors in Patients with Panic Disorder and Obsessive-Compulsive Disorder

Changes in Peripheral Benzodiazepine Receptors in Patients with Panic Disorder and Obsessive-Compulsive Disorder

Searching for the Biological Pathways Between Stress and Health

"Peripheral" Benzodiazepine Receptor Density Is Not Altered by Methylphenidate Treatment in Children with Attention-Deficit Hyperactivity Disorder

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