Examining cognitive speed and accuracy dysfunction in youth and young adults with pediatric-onset multiple sclerosis using a computerized neurocognitive battery.

Barlow-Krelina, Emily; Fabri, Tracy L.; O’Mahony, Julia; Gur, Ruben C.; Gur, Raquel E.; Somma, Elisea De; Bolongaita, Lady; Dunn, Candice L; Bacchus, Micky K.; Yeh, E. Ann; Marrie, Ruth Ann; Bar‐Or, Amit; Banwell, Brenda; Till, Christine

doi:10.1037/neu0000729

Cited by 7 publications

(2 citation statements)

References 57 publications

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“…This suggested that the prolongation of reaction time might be a result of an effort to reduce the rate of error. Previous studies also supported that SRTT results indicated longer reaction times in patients with MS and that this difference became further manifest with increased severity of disease (18)(19)(20)(21)(22). Previous studies on memory in patients with MS generally reported impaired memory (23)(24)(25)(26)(27)(28)(29).…”

Section: Discussionmentioning

confidence: 55%

Evaluation of Patients with Multiple Sclerosis in Terms of Memory, Attention, Executive Functions, Fine Motor Movement and the Association thereof with Magnetic Resonance Imaging Results

Sahin,

Kılıçaslan Şahin,

Dağ

2024

Düzce Tıp Fakültesi Dergisi

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Aim: This study aimed to review cognitive function and fine motor skills in patients with multiple sclerosis (MS) and investigate the association with magnetic resonance imaging (MRI) results. Material and Methods: The study included 22 patients diagnosed with relapsing-remitting MS and 22 controls. Participants underwent neuropsychological tests, including the Stroop test, Rey auditory verbal learning test (RAVLT), line bisection test (LBT), serial reaction time test (SRTT), and finger tapping test (FTT). The relationship between severity of disease, MRI, and test performance was investigated. Results: It was determined that the patients were lateralized to the right in the LBT data, while the control group was lateralized to the left (p=0.024). On cognitive tests, there was no significant difference in Stroop test results (p=0.134), but the mean overall RAVLT of the patient group was significantly lower than that of the control group (p

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Section: Discussionmentioning

confidence: 55%

Evaluation of Patients with Multiple Sclerosis in Terms of Memory, Attention, Executive Functions, Fine Motor Movement and the Association thereof with Magnetic Resonance Imaging Results

Sahin,

Kılıçaslan Şahin,

Dağ

2024

Düzce Tıp Fakültesi Dergisi

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“…Moreover, the study showed an association between higher IQ and older age at disease onset, shorter MS duration and lower EDSS. Using a computerized neurocognitive battery, a more recent study demonstrated reduced accuracy on tests of attention/inhibition, visuospatial processing working memory and verbal memory (after adjusting for response time), in adolescents and young adults with POMS, compared with healthy control [ 26 ]. On the other hand, the absence of significant differences between cognitive performances among pediatric patients compared with a control healthy group was described in a recent study by Krupp et al [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

Neuropsychological performances, quality of life, and psychological issues in pediatric onset multiple sclerosis: a narrative review

Tarantino,

Proietti Checchi,

Papetti

et al. 2023

Neurol Sci

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Multiple sclerosis (MS) is primarily a disease diagnosed in young and middle-aged adults. Although MS is a rare condition in pediatric age, an increasing rate of patients is diagnosed under the age of 18. The disabling nature of the disease cannot be reduced only to physical symptoms. Several additional symptoms such as cognitive impairment, fatigue, and psychological symptoms are common features of pediatric MS. The reviewed literature suggests that, despite the lower physical disability, children and adolescents diagnosed with MS are vulnerable to cognitive impairment even in the early stage of the disease. The neuropsychological profile of pediatric MS may resemble that of adult MS, including an impairment in attention/information processing speed, learning, verbal, and visuospatial memory. However, cognitive difficulties in children and adolescents are more likely to involve also general intelligence and linguistic abilities, presumably due to patients’ younger age and cognitive growth stage. Cognitive difficulties, beyond physical disability and relapses, may have a considerable impact on learning and school achievement. Depression and fatigue are other highly prevalent disturbances in pediatric MS and may contribute to patients’ low functional outcomes. Overall, these manifestations may cause considerable functional impairment on daily activities and quality of life that may require individualized rehabilitative treatment and extensive psychosocial care. Additional neuropsychological research evaluating larger samples, using more homogenous methods, and exploring the role of MS treatment on cognitive and psychological development is required.

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Pediatric multiple sclerosis and acute disseminated encephalomyelitis

O'Neill,

Fernandez-Carbonell,

Maletic-Savatic

et al. 2024

The Rose and Mackay Textbook of Autoimmune Diseases

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Examining cognitive speed and accuracy dysfunction in youth and young adults with pediatric-onset multiple sclerosis using a computerized neurocognitive battery.

Cited by 7 publications

References 57 publications

Evaluation of Patients with Multiple Sclerosis in Terms of Memory, Attention, Executive Functions, Fine Motor Movement and the Association thereof with Magnetic Resonance Imaging Results

Evaluation of Patients with Multiple Sclerosis in Terms of Memory, Attention, Executive Functions, Fine Motor Movement and the Association thereof with Magnetic Resonance Imaging Results

Neuropsychological performances, quality of life, and psychological issues in pediatric onset multiple sclerosis: a narrative review

Pediatric multiple sclerosis and acute disseminated encephalomyelitis

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