Examining health-related quality of life patterns in women with breast cancer

Abstract

Purpose We aimed to identify subgroups of women with breast cancer who experience different health-related quality of life (HRQOL) patterns during active treatment and survivorship and determine characteristics associated with subgroup membership. Methods We used data from the third phase of the population-based Carolina Breast Cancer Study and included 2,142 women diagnosed with breast cancer from 2008–2013. HRQOL was measured, on average, 5- and 25-months post-diagnosis. Latent profile analysis was used to identify HRQOL latent profiles (LPs) at each time point. Latent transition analysis was used to determine probabilities of women transitioning profiles from 5- to 25-months. Multinomial logit models estimated adjusted odds ratios (aORs) and 95% confidence intervals for associations between patient characteristics and LP membership at each time point. Results We identified four HRQOL LPs at 5- and 25-months. LP1 had the poorest HRQOL and LP4 the best. Membership in the poorest profile at 5-months was associated with younger age aOR 0.95; 0.93–0.96, White race aOR 1.48; 1.25–1.65, being unmarried aOR 1.50; 1.28–1.65, and having public aOR 3.09; 1.96–4.83 or no insurance aOR 6.51; 2.12–20.10. At 25-months, Black race aOR 1.75; 1.18–1.82 was associated with poorest profile membership. Black race and smoking were predictors of deteriorating to a worse profile from 5- to 25- months. Conclusions Our results suggest patient-level characteristics including age at diagnosis and race may identify women at risk for experiencing poor HRQOL patterns. If women are identified and offered targeted HRQOL support, we may see improvements in long-term HRQOL and better breast cancer outcomes.

Health‐related quality of life outcomes among breast cancer survivors

“…Previous work has shown that women with breast cancer may experience impaired physical and emotional functioning after cancer treatment 12‐24 . Several demographic and clinical determinants may negatively influence survivors' HRQOL 12‐18 .…”

“…Previous work has shown that women with breast cancer may experience impaired physical and emotional functioning after cancer treatment 12‐24 . Several demographic and clinical determinants may negatively influence survivors' HRQOL 12‐18 . For instance, breast cancer survivors with comorbid conditions, such as heart failure, 19 arthritis, 13,20 diabetes, 13 and lymphedema, 20,21 have poorer physical and mental health outcomes than those without these conditions 20,22‐24 .…”

Qualidade de Vida de Mulheres Negras com Câncer de Mama: Uma Revisão de Literatura

“…Com relação à sobrevivência, é imprescindível assinalar que Samuel et al (2016), Pinheiro et al (2016), Pinheiro et al (2017), Vadaparampil et al (2017) e Claridy, Ansa, Damus, Alema-Mensah e Smith (2018) não concordaram quanto aos parâmetros temporais referentes a essa etapa da experiência oncológica. Seus estudos acataram desde o período de recebimento do diagnóstico até um período indeterminado que pode ser confundido com o próprio ciclo vital da paciente.…”

Perceptions of a Breast Cancer Survivorship Intervention: Pearls of Wisdom from Young African American Women

“…This group displayed high education attainment, but the impact of socioeconomic status on QOL and information needs across other studies is inconclusive. [45][46][47] Although one participant did not complete the second interview, data saturation was met and findings were verified by the participants. Maximum variation improved sample heterogeneity, but a larger sample may have yielded additional findings.…”