Context: Minimalist shoes have been suggested as a way to alter running biomechanics to improve running performance and reduce injuries. However, to date, researchers have only considered the effect of minimalist shoes at slow running speeds.Objective: To determine if runners change foot-strike pattern and alter the distribution of mechanical work at the knee and ankle joints when running at a fast speed in minimalist shoes compared with conventional running shoes.Design: Crossover study. Setting: Research laboratory.Patients or Other Participants: Twenty-six trained runners (age ¼ 30.0 6 7.9 years [age range, 18À40 years], height ¼ 1.79 6 0.06 m, mass ¼ 75.3 6 8.2 kg, weekly training distance ¼ 27 6 15 km) who ran with a habitual rearfoot foot-strike pattern and had no experience running in minimalist shoes.Intervention(s): Participants completed overground running trials at 18 km/h in minimalist and conventional shoes.Main Outcome Measure(s): Sagittal-plane kinematics and joint work at the knee and ankle joints were computed using 3-dimensional kinematic and ground reaction force data. Footstrike pattern was classified as rearfoot, midfoot, or forefoot strike based on strike index and ankle angle at initial contact.Results Conclusions: Running in minimalist shoes at a fast speed caused a redistribution of work from the knee to the ankle joint. This finding suggests that runners changing from conventional to minimalist shoes for short-distance races could be at an increased risk of ankle and calf injuries but a reduced risk of knee injuries.