Examining Mannitol Use in Kidney Cancer Surgery: A Cautionary Tale of Extrapolated Surgical Data

Nair, Shiva M.; Power, Nicholas; Coleman, Jonathan

doi:10.1016/j.euf.2019.09.021

Cited by 4 publications

(2 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this issue, Nahar et al [10] argue that a reasonable ischemia period is unlikely to damage the kidney and should not be a metric of quality for partial nephrectomy. Meanwhile, Nair et al [11] contextualize findings from a phase 3 clinical trial that assessed the utility of intravenous mannitol administration during NSS.…”

Section: What and How To Cutmentioning

confidence: 99%

Modern Management of Kidney Cancer: Is a Chance to Cut a Chance to Cure?

Kutikov

2019

European Urology Focus

View full text Add to dashboard Cite

Section: What and How To Cutmentioning

confidence: 99%

Modern Management of Kidney Cancer: Is a Chance to Cut a Chance to Cure?

Kutikov

2019

European Urology Focus

View full text Add to dashboard Cite

“…Renal ischemia-reperfusion (I/R) injury (IRI) occurs clinically in different circumstances, such as partial nephrectomy [ 1 ], renal transplantation [ 2 ], complex cardiovascular surgeries requiring cardiac arrest [ 3 , 4 ], postresuscitation shock [ 5 ], and chemical agent/drug-induced renal toxicity [ 6 ]. It is the most familiar cause of the development of acute renal injury and an important influential factor for kidney transplant prognosis [ 2 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Estrogen Protects against Renal Ischemia-Reperfusion Injury by Regulating Th17/Treg Cell Immune Balance

et al. 2022

View full text Add to dashboard Cite

Inflammation is a critical mediator of renal ischemia-reperfusion (I/R) injury (IRI), and T lymphocytes exert a key role in the renal IRI-induced inflammation. Connexin 43 (Cx43) is related to the maintenance of T lymphocyte homeostasis. Various preclinical researches have reported that estrogen is a renoprotective agent based on its anti-inflammatory potential. The present research is aimed at studying the role of T lymphocytes activated by Cx43 in 17β-estradiol-mediated protection against renal IRI. Female rats were classified into six groups: control rats, I/R rats, ovariectomized rats, ovariectomized I/R rats, and ovariectomized rats treated with 17β-estradiol or gap27. Levels of serum creatinine (Scr) and blood urea nitrogen (BUN) and Paller scoring were dramatically increased in I/R rats, especially in ovariectomized rats. By contrast, these indicators were markedly decreased by administering estradiol or gap27. Immunofluorescence staining revealed that CD4+ T cells infiltrated kidney tissues in the early stage of IRI. In both peripheral blood and renal tissue, the proportion of CD3+CD4+ T cells and ratio of CD4+ to CD8+ were high in I/R rats, especially in ovariectomized rats. The proportion of CD3+CD8+ T cells was low in peripheral blood but high in renal tissues. Administration of estrogen or Gap27 reversed these effects. IL-17 levels in both serum and tissue homogenate were significantly increased in ovariectomized rats subjected to I/R but significantly decreased in estrogen or gap 27 treated rats. The opposite trend was observed for IL-10 levels. Correlation analysis demonstrated that IL-17 was correlated positively with BUN, Scr, and Paller scores, while IL-10 was negatively correlated with these indicators. Western blot showed that Cx43 expression was markedly increased in the peripheral blood T lymphocytes of I/R rats, especially ovariectomized rats. After intervention with estrogen and gap27, Cx43 expression was significantly downregulated. These findings indicate that Cx43 may participate in the regulation of Th17/Treg balance by estrogen against renal IRI.

show abstract

Physiology, Pathophysiology, and Anesthetic Management of Patients with Renal Disease

Clark‐Price,

Fischer

2024

Veterinary Anesthesia and Analgesia

View full text Add to dashboard Cite

Examining Mannitol Use in Kidney Cancer Surgery: A Cautionary Tale of Extrapolated Surgical Data

Cited by 4 publications

References 55 publications

Modern Management of Kidney Cancer: Is a Chance to Cut a Chance to Cure?

Modern Management of Kidney Cancer: Is a Chance to Cut a Chance to Cure?

Estrogen Protects against Renal Ischemia-Reperfusion Injury by Regulating Th17/Treg Cell Immune Balance

Physiology, Pathophysiology, and Anesthetic Management of Patients with Renal Disease

Contact Info

Product

Resources

About