Examining Muscle Regeneration in Zebrafish Models of Muscle Disease

Montandon, Margo; Currie, Peter D.; Ruparelia, Avnika A.

doi:10.3791/62071

Cited by 8 publications

(6 citation statements)

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“…Macrophages resident within muscle tissue are highly plastic in establishing the stem cell niche and interact with satellite and other cells (Ratnayake et al 2021). Experiments using a beautifully designed system to follow individual macrophages in real time in living zebrafish (Montandon et al 2021) revealed that there are early interactions of muscle-resident macrophages with satellite cells through a macrophage-secreted compound, nicotinamide phosphoribosyl transferase (NAMPT). NAMPT in turn, acts via the CCR5 chemokine receptor and establishes a short-lived niche that activates satellite cells; the same signaling contributes to regulate the pace and timing of myogenic regeneration (Ratnayake et al 2021).…”

Section: Inflammationmentioning

confidence: 99%

“…Again, fiber type plays a role, since shear forces on the sarcolemma are higher in rapidly contracting type-II fibers and make them more susceptible to exercise-related damage. Different species and taxa also present fascinating distinctions across many features of muscle development, satellite cell distribution and regulation, muscle use, and evolutionary modifications based on life-history that may affect regeneration capacity, as recently explored in a variety of fish species (Zhang and Anderson 2014;Knappe et al 2015;Gurevich et al 2016;Ratnayake and Currie 2017;Anderson et al 2019;Pourghadamyari et al 2019;Tingle et al 2019;Christian and Benian 2020;Hiebert and Anderson 2020;Montandon et al 2021). Although autophagy may decrease with aging, inducing an increase in autophagy can rescue the effectiveness of regeneration by muscles in old animals (Park et al 2019;.…”

Section: Myogenesis Vs Muscle-tissue Regenerationmentioning

confidence: 99%

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Key concepts in muscle regeneration: muscle “cellular ecology” integrates a gestalt of cellular cross-talk, motility, and activity to remodel structure and restore function

Anderson

2021

Eur J Appl Physiol

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This review identifies some key concepts of muscle regeneration, viewed from perspectives of classical and modern research. Early insights noted the pattern and sequence of regeneration across species was similar, regardless of the type of injury, and differed from epimorphic limb regeneration. While potential benefits of exercise for tissue repair was debated, regeneration was not presumed to deliver functional restoration, especially after ischemia–reperfusion injury; muscle could develop fibrosis and ectopic bone and fat. Standard protocols and tools were identified as necessary for tracking injury and outcomes. Current concepts vastly extend early insights. Myogenic regeneration occurs within the environment of muscle tissue. Intercellular cross-talk generates an interactive system of cellular networks that with the extracellular matrix and local, regional, and systemic influences, forms the larger gestalt of the satellite cell niche. Regenerative potential and adaptive plasticity are overlain by epigenetically regionalized responsiveness and contributions by myogenic, endothelial, and fibroadipogenic progenitors and inflammatory and metabolic processes. Muscle architecture is a living portrait of functional regulatory hierarchies, while cellular dynamics, physical activity, and muscle–tendon–bone biomechanics arbitrate regeneration. The scope of ongoing research—from molecules and exosomes to morphology and physiology—reveals compelling new concepts in muscle regeneration that will guide future discoveries for use in application to fitness, rehabilitation, and disease prevention and treatment.

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Section: Inflammationmentioning

confidence: 99%

Section: Myogenesis Vs Muscle-tissue Regenerationmentioning

confidence: 99%

Key concepts in muscle regeneration: muscle “cellular ecology” integrates a gestalt of cellular cross-talk, motility, and activity to remodel structure and restore function

Anderson

2021

Eur J Appl Physiol

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“…The disruption of the regular muscle structure, caused by dystrophy or injury, can be detected in polarised light as a dark area, in contrast to bright, unchanged muscle structure. This simple method, known as birefringence assay, allows for qualitative and quantitative measurement of muscle integrity [ 164 , 165 ]. There are also several microscopic techniques based on the distinct kinds of staining.…”

Section: Perspectivesmentioning

confidence: 99%

Zebrafish as a Model for the Study of Lipid-Lowering Drug-Induced Myopathies

Dubińska–Magiera

Migocka-Patrzałek

Lewandowski

et al. 2021

IJMS

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Drug-induced myopathies are classified as acquired myopathies caused by exogenous factors. These pathological conditions develop in patients without muscle disease and are triggered by a variety of medicaments, including lipid-lowering drugs (LLDs) such as statins, fibrates, and ezetimibe. Here we summarise the current knowledge gained via studies conducted using various models, such as cell lines and mammalian models, and compare them with the results obtained in zebrafish (Danio rerio) studies. Zebrafish have proven to be an excellent research tool for studying dyslipidaemias as a model of these pathological conditions. This system enables in-vivo characterization of drug and gene candidates to further the understanding of disease aetiology and develop new therapeutic strategies. Our review also considers important environmental issues arising from the indiscriminate use of LLDs worldwide. The widespread use and importance of drugs such as statins and fibrates justify the need for the meticulous study of their mechanism of action and the side effects they cause.

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“…Their complex organs, such as fins, the heart, and central nervous system structures, can be efficiently restored after major injuries by amputation, resection, or freezing [1][2][3] . Skeletal muscle regenerates after minor damage [4][5][6][7][8] . Whether extensive degeneration of locomotory musculature is followed by a restoration process has not yet been analyzed in adult zebrafish.…”

mentioning

confidence: 99%

“…As in mammals, muscle progenitors receive cues from their niche to undergo transition into myoblasts and finally mature myofibers 35 . The activation of satellite cells has been demonstrated after local chemical injury or stab wounding in larval and adult zebrafish [4][5][6][7][8] . However, in some other injury models, no evidence of stem cell activation has been identified.…”

mentioning

confidence: 99%

Skeletal muscle regeneration after extensive cryoinjury of caudal myomeres in adult zebrafish

Oudhoff,

Hisler,

Baumgartner

et al. 2024

npj Regen Med

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Skeletal muscles can regenerate after minor injuries, but severe structural damage often leads to fibrosis in mammals. Whether adult zebrafish possess the capacity to reproduce profoundly destroyed musculature remains unknown. Here, a new cryoinjury model revealed that several myomeres efficiently regenerated within one month after wounding the zebrafish caudal peduncle. Wound clearance involved accumulation of the selective autophagy receptor p62, an immune response and Collagen XII deposition. New muscle formation was associated with proliferation of Pax7 expressing muscle stem cells, which gave rise to MyoD1 positive myogenic precursors, followed by myofiber differentiation. Monitoring of slow and fast muscles revealed their coordinated replacement in the superficial and profound compartments of the myomere. However, the final boundary between the muscular components was imperfectly recapitulated, allowing myofibers of different identities to intermingle. The replacement of connective with sarcomeric tissues required TOR signaling, as rapamycin treatment impaired new muscle formation, leading to persistent fibrosis. The model of zebrafish myomere restoration may provide new medical perspectives for treatment of traumatic injuries.

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Examining Muscle Regeneration in Zebrafish Models of Muscle Disease

Cited by 8 publications

References 0 publications

Key concepts in muscle regeneration: muscle “cellular ecology” integrates a gestalt of cellular cross-talk, motility, and activity to remodel structure and restore function

Key concepts in muscle regeneration: muscle “cellular ecology” integrates a gestalt of cellular cross-talk, motility, and activity to remodel structure and restore function

Zebrafish as a Model for the Study of Lipid-Lowering Drug-Induced Myopathies

Skeletal muscle regeneration after extensive cryoinjury of caudal myomeres in adult zebrafish

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