Examining object recognition and object-in-Place memory in plateau zokors, Eospalax baileyi

Hegab, Ibrahim M.; Tan, Yuchen; Wang, Chan; Yao, Baohui; Wang, Haifang; Ji, Weihong; Su, Jian

doi:10.1016/j.beproc.2017.11.007

Cited by 14 publications

(4 citation statements)

References 58 publications

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“…In our study, naloxone reversed the morphine‐induced recognition memory deficit. The Y‐maze has been used to determine the morphine‐induced change in spatial working memory (Hegab et al, ). However, no significant differences were observed after repeated morphine.…”

Section: Discussionmentioning

confidence: 99%

Naloxone reversed cognitive impairments induced by repeated morphine under heavy perceptual load in the 5‐choice serial reaction time task

Guo

Xie

Cui

et al. 2019

J of Neuroscience Research

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Repeated opioids abuse may produce long‐lasting and complicated cognitive deficits in individuals. Naloxone is a typical mu‐opioid receptor antagonist widely used in clinical treatment for opioid overdose and opioid abuse. However, it remains unclear whether naloxone affects morphine‐induced cognitive deficits. Using the 5‐choice serial reaction time task (5‐CSRTT), the present study investigated cognitive profiles including attention, impulsivity, compulsivity, and processing speed in repeated morphine‐treated mice. Repeated morphine administration (10 mg/kg, i.p.) induced complex cognitive changes including decreased attention and increased impulsivity, compulsivity, processing speed. Systemic naloxone administration (5 mg/kg, i.p.) reversed these cognitive changes under the heavy perceptual load in 5‐CSRTT. Using the novel object recognition (NOR), Y‐maze and open‐field test (OFT), the present study investigated the memory ability and locomotor activity. Naloxone reversed the effect of morphine on recognition memory and locomotion but had no effect on working memory. In addition, repeated morphine administration decreased the expression of postsynaptic density protein 95 (PSD95) and cAMP response element binding protein (CREB) phosphorylation in the prefrontal cortex (PFC) and hippocampus (HIP), and these effects were significantly reversed by naloxone in PFC. Our study suggests that repeated exposure to morphine affects multiple cognitive aspects and impairs synaptic functions. Systemic naloxone treatment reverses the mu‐opioids‐induced cognitive changes, especially under the heavy perceptual load, possibly by restoring the synaptic dysfunctions.

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Section: Discussionmentioning

confidence: 99%

Naloxone reversed cognitive impairments induced by repeated morphine under heavy perceptual load in the 5‐choice serial reaction time task

Guo

Xie

Cui

et al. 2019

J of Neuroscience Research

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“…The animals were housed in the laboratory for seven days without contact to reduce stress and given ad libitum access to their preferred food (carrots and potatoes) during the acclimatization and experimental period. The temperature was maintained at 12 ± 4 °C and humidity at 45–55% [ 53 ]. Our experiments were approved by the Animal Ethics Committee of Gansu Agricultural University and supported by the local government (GAU-LC-2020-014).…”

Section: Methodsmentioning

confidence: 99%

Comparative transcriptomes reveal geographic differences in the ability of the liver of plateau zokors (Eospalax baileyi) to respond and adapt to toxic plants

Tan,

Wang,

Liu

et al. 2023

BMC Genomics

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Background Environmental changes are expected to intensify in the future. The invasion of toxic plants under environmental changes may change herbivore feeding environments. Herbivores living long-term in toxic plant-feeding environments will inevitably ingest plant secondary metabolites (PSMs), and under different feeding environments are likely to have unique protection mechanisms that support improved adaptation to PSMs in their habitat. We aimed to compare different subterranean herbivore population responses and adaptations to toxic plants to unveil their feeding challenges. Results Here, we investigated the adaptive capacity of the liver in two geographically separated populations of plateau zokors (Eospalax baileyi) before and after exposure to the toxic plant Stellera chamaejasme (SC), at the organ, biochemical, and transcriptomic levels. The results showed no significant liver granules or inflammatory reactions in the Tianzhu (TZ) population after the SC treatment. The transaminase level in the TZ population was significantly lower than that in the Luqu population. Transcriptome analysis revealed that the TZ population exhibited interactions with other detoxification metabolic pathways by oxytocin pathway-associated genes, including diacylglycerol lipase alpha (Dagla), calcium/calmodulin dependent protein kinase II Alpha (Camk2a), and CD38 molecule (Cd38). The phase II process of liver drug metabolism increased to promote the rate of metabolism. We found that alternative splicing (AS) and the expression of the cyclin D (Ccnd1) gene interact—a TZ population hallmark—reduced liver inflammatory responses. Conclusion Our study supports the detoxification limitation hypothesis that differences in liver detoxification metabolism gene expression and AS are potential factors in herbivore adaptation to PSMs and may be a strategy of different herbivore populations to improve toxic plant adaptability.

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“…Our result was that CO voles displayed decreased object and place recognition compared to DW voles is consistent with these studies. In wild niches, exploration of novel objects or places that depart from normal circumstances comprises ambulatory and investigatory responses, which help acquaint animals with their surroundings, secure better information, avoid danger, and gain prospective knowledge, which can affect their survival [91]. Thus, deficient object and place recognition ability in CO voles could very well contribute to an altered life strategy, e.g., improving reproduction, to increase inclusive fitness.…”

Section: Effects On Cognitive Performance In Adulthoodmentioning

confidence: 99%

Adolescence Predatory Risk Alters Social Behaviors and Cognitive Ability and Central Oxytocin and Vasopressin Expression in Adult Brandt’s Voles

Pang

et al. 2022

Neuroendocrinology

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Introduction: Stress during adolescence causes long-term behavioral changes in adulthood. We previously found that adolescent exposure to predatory risk augments adolescent social contact and adult parental behavior in Brandt’s voles (Lasiopodomys brandtii). Methods: Here we determined whether this experience alters sexual behavior, pair-bond formation, and recognition ability, as well as basal HPA axis activity, central oxytocin (OT), and arginine-vasopressin (AVP) expression in adulthood. Results: In the social interaction test, repeated cat odor (CO) exposure enhanced the frequency of lordosis by female voles toward an unfamiliar opposite-sex conspecific. CO voles preferred to engage with their partners after 48 h cohabitation whereas the control groups did not, which may reflect stable pair bonds in the CO treatment group. Furthermore, adolescent exposure to CO inhibited novel object and place recognition ability, while it influenced social recognition only among adult males. No effect of adolescent CO exposure was observed for basal HPA axis activity, showing a habituation effect. Finally, we found that CO exposure increased OT and decreased AVP expression in the hypothalamus, including the paraventricular nucleus and anterior hypothalamus. The levels of OT in the medial amygdala were lower, and AVP in the lateral septum was higher in CO voles compared with the control. Discussion/Conclusion: These findings demonstrate that adolescent exposure to predator risk promotes adult reproductive behavior of Brandt’s voles. Deficits in recognition ability may necessitate alterations in reproductive strategies to enhance inclusive fitness. OT and AVP systems may play a modulatory role in the alteration of social behaviors elicited by adolescent predatory risk.

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Examining object recognition and object-in-Place memory in plateau zokors, Eospalax baileyi

Cited by 14 publications

References 58 publications

Naloxone reversed cognitive impairments induced by repeated morphine under heavy perceptual load in the 5‐choice serial reaction time task

Naloxone reversed cognitive impairments induced by repeated morphine under heavy perceptual load in the 5‐choice serial reaction time task

Comparative transcriptomes reveal geographic differences in the ability of the liver of plateau zokors (Eospalax baileyi) to respond and adapt to toxic plants

Adolescence Predatory Risk Alters Social Behaviors and Cognitive Ability and Central Oxytocin and Vasopressin Expression in Adult Brandt’s Voles

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