Examining protocol compliance and self-report congruence between daily diaries and event-contingent ecological momentary assessments of college student drinking

Hultgren, Brittney A.; Scaglione, Nichole M.; Buben, Alex; Turrisi, Rob

doi:10.1016/j.addbeh.2020.106471

Cited by 13 publications

(10 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PCP is a potent non-competitive N-methyl-D-aspartate receptor (NMDA-R) antagonist that can result in symptoms such as hallucinations, delusions, and disorganized speech, thereby mimicking the episodic phase of psychosis in humans (Bubeníková-Valeš sová et al, 2008). The class of arylcyclohexylamine anesthetics, such as ketamine and PCP, exerts a complex array of behavioral and neurochemical effects in the brain, which are considered part of the basis of the NMDA-R hypofunction hypothesis of SCZ (Javitt and Zukin, 1991;Castañé et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia

Calovi

Mut-Arbona

Tod

et al. 2020

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Background : It has been consistently reported that the deficiency of the adenosine triphosphate (ATP) sensitive purinergic receptor P2X7 (P2X7R) ameliorates symptoms in animal models of brain diseases. Objective : This study aimed to investigate the role of P2X7R in rodent models of acute and subchronic schizophrenia based on phencyclidine (PCP) delivery in animals lacking or overexpressing P2X7R, and to identify the underlying mechanisms involved. Methods : The psychotomimetic effects of acute i.p. PCP administration in C57Bl/6J wild-type, P2X7R knockout (P2rx7 −/− ) and overexpressing (P2X7-EGFP) young adult mice were quantified. The medial prefrontal cortex (mPFC) of P2rx7 −/− and heterozygous P2X7-EGFP acutely treated animals was characterized through immunohistochemical staining. The prefrontal cortices of young adult P2rx7 −/− and P2rx7 tg/+ mice were examined with tritiated dopamine release experiments and the functional properties of the mPFC pyramidal neurons in layer V from P2rx7 −/− mice were assessed by patch-clamp recordings. P2rx7 −/− animals were subjected to a 7 days subchronic systemic PCP treatment. The animals working memory performance and PFC cytokine levels were assessed. Results : Our data strengthen the hypothesis that P2X7R modulates schizophrenia-like positive and cognitive symptoms in NMDA receptor antagonist models in a receptor expression level-dependent manner. P2X7R expression leads to higher medial PFC susceptibility to PCP-induced circuit hyperactivity. The mPFC of P2X7R knockout animals displayed distinct alterations in the neuronal activation pattern, microglial organization, specifically around hyperactive neurons, and were associated with lower intrinsic excitability of mPFC neurons. Conclusions : P2X7R expression exacerbated PCP-related effects in C57Bl/6J mice. Our findings suggest a pleiotropic role of P2X7R in the mPFC, consistent with the observed behavioral phenotype, regulating basal dopamine concentration, layer-specific neuronal activation, intrinsic excitability of neurons in the mPFC, and the interaction of microglia with hyperactive neurons. Direct measurements of P2X7R activity concerning microglial ramifications and dynamics could help to further elucidate the molecular mechanisms involved.

show abstract

Section: Introductionmentioning

confidence: 99%

P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia

Calovi

Mut-Arbona

Tod

et al. 2020

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

“…The current study utilizes daily assessments with detailed timing questions as opposed to momentary ecological assessments because of the limitations related to completing assessments in the moment while under the influence [ 89 , 90 ]. This detailed time assessment will allow us to determine impairment with less subjectivity than self-report of impaired driving and will provide insight on how often young adults may be driving impaired without judging themselves as impaired.…”

Section: Discussionmentioning

confidence: 99%

Daily level predictors of impaired driving behaviors in young adults: Protocol design for utilizing daily assessments

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background Motor vehicle crashes remain a leading cause of death among young adults (ages 18–25) in the United States. Many drivers implicated in these crashes are under the influence of alcohol, cannabis, or the simultaneous use of alcohol and cannabis. Extremely limited research has assessed impaired driving behaviors and their predictors at the daily level. Perceived norms and motives to use substances have empirical support suggesting they may impact impaired driving-related behavior. Novel approaches to assess these associations at the daily level are needed and may inform future intervention and prevention programs. Objective The goal of the current study is to utilize electronic daily assessments to assess driving under the influence of alcohol, cannabis, or simultaneous use and riding with a driver impaired by these substances to assess variability and predictors of these impaired driving-related behaviors at the daily level. This present manuscript details a protocol, measures, and a plan of analyses to assess how within-person differences in perceived norms and motives to use are associated with the likelihood of engaging in impaired driving-related behaviors. Methods Participants include young adults in Washington State who report simultaneous use in the past month and either driving under the influence of alcohol, cannabis, or simultaneous use, or riding with a driver under the influence of both substances in the past 6 months. Individuals who verify their identity and meet eligibility requirements will complete a baseline assessment after which they will be scheduled for training on the daily assessment procedure via Zoom. Next, they will be invited to complete daily surveys on Thursday, Friday, Saturday, and Sunday every other week for 6 months and a 6-month follow up assessment. Analyses will utilize multilevel models with days nested within individuals. Results The study is currently recruiting participants. A total of 192 participants have been recruited and 100 have completed the study protocol. Data collection is expected to be completed in Fall 2022. Conclusions This study utilizes a novel design to assess impaired driving and predictors at the daily level among young adults at high risk of impaired driving-related behaviors. Findings will provide unique data that will shape the knowledge base in the field of social science and public health substance use research and that may be helpful for future prevention and intervention efforts on impaired driving.

show abstract

“…At the end of each training, participants completed a trial survey and a procedural knowledge test on how and when to complete the EMA surveys. Study staff then reviewed answers and discussed incorrect answers with the group (see Hultgren et al, 2020). Trained research assistants also observed and coded each training session for fidelity to ensure consistency in training over time and across participants.…”

Section: Methodsmentioning

confidence: 99%

Alcohol's Role in Sexual Decision Making in First-Year College Women: An Event-Level Assessment

Scaglione

Ward

Buben³

et al. 2023

Psychology of Women Quarterly

Self Cite

View full text Add to dashboard Cite

Sexual decision making is often grounded in social scripts that can be detrimental to women's healthy relationships and sexual development during the transition to college. Little is known about the malleable decision-making processes and drinking behaviors that influence sexual behaviors from day-to-day. We examined whether women were more likely to engage in sexual behaviors on days they had higher intentions and willingness to engage in sex or drink alcohol. We also explored interactions between sex- and alcohol-related decision constructs. Eighty-two first-year college women completed 14 days of ecological momentary assessment, reporting on alcohol- and sex-related intentions and willingness (3x daily) and daily drinking and sexual behaviors. We found partial support for our hypotheses: intentions and willingness to have sex were positively associated with sex behaviors, but the willingness to drink was negatively associated with sex behaviors. Heavy drinking was associated with sexual behavior, even when women indicated no prior willingness to engage in sexual behavior on those days. Findings highlight the need to address event-level variability in sexual decision making, with a particular focus on how alcohol impacts these processes. Further, the robust association between sexual intentions and behavior suggests intention setting may be a particularly useful sexual empowerment education tool.

show abstract

Examining protocol compliance and self-report congruence between daily diaries and event-contingent ecological momentary assessments of college student drinking

Cited by 13 publications

References 28 publications

P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia

P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia

Daily level predictors of impaired driving behaviors in young adults: Protocol design for utilizing daily assessments

Alcohol's Role in Sexual Decision Making in First-Year College Women: An Event-Level Assessment

Contact Info

Product

Resources

About