Examining the antitumoral effect of cornelian cherry (Cornus mas) in ehrlich ascites tumor-induced mice

Yılmaz, Seher; Alpa, Şerife; Nisari, Mehtap; Karatoprak, Gökçe Şeker; Doğanyiğit, Züleyha; Ülger, Harun; Ertekın, Tolga

doi:10.4103/jasi.jasi_28_19

Cited by 6 publications

(5 citation statements)

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“…In one study, the aqueous extract of C. mas exhibited cytotoxicity against MCF-7 cells at a high dose of 750 μg/mL [ 44 ]. In a study examining the antitumor effect of C. mas fruit in Balb/C mice, C. mas extract was found to strongly inhibit cancer proliferation in vitro [ 45 ]. Consistent with the literature, the data of this study showed that B. vulgaris and C. mas extract significantly reduced breast cancer cell proliferation in a time- and dose-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

Acetone extracts of Berberis vulgaris and Cornus mas L. induce apoptosis in MCF-7 breast cancer cells

USLU,

YAMAN,

SANCI

et al. 2023

Turkish Journal of Medical Sciences

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Background/aim This study aimed to determine the proliferation and apoptotic effects of extracts from Cornus mas L. and Berberis vulgaris fruits on human breast cancer cells (MCF-7). Materials and methods The Cornus mas L. and Berberis vulgaris fruits, which constitute the herbal material of the study, were turned into 80% acetone extract after washing. The total phenolic content in Berberis vulgaris fruit extracts was determined calorimetrically using Folin-Ciocalteu reagent. The spectrophotometric method was used to determine the total flavonoid amount of the extracts. In order to measure the antioxidant capacity of Cornus mas L. and Berberis vulgaris fruits and extracts, DPPH Radical Scavenging Power test and Cu (II) ion reducing antioxidant capacity method were applied. Cell viability rates were determined by the XTT method. Flow cytometric measurement was performed to examine the apoptotic role of the extracts in the cell by using the Annexin-V/7-AAD commercial kit. Results According to the data, Berberis vulgaris fruit extract appeared more effective on MCF-7 breast cancer cells in both 24 and 48 hours of exposure. Analyses made to examine the phenolic component and antioxidant capacity properties of the fruits used in the study and the results we encountered when we exposed the cell were found to be compatible with each other. Annexin-V/7-AAD method showed that the apoptotic effects of the extracts in 48 hour exposures were more effective. Conclusion It has been determined that Cornus mas L. and Berberis vulgaris fruits, which are rich in phenolic components with high flavonoid content and high antioxidant capacities, support the apoptosis of cancer cells.

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Section: Discussionmentioning

confidence: 99%

Acetone extracts of Berberis vulgaris and Cornus mas L. induce apoptosis in MCF-7 breast cancer cells

USLU,

YAMAN,

SANCI

et al. 2023

Turkish Journal of Medical Sciences

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“…Many inhibit a large molecular target range in the micromolar concentration range by downregulating or suppressing a large number of inflammatory pathways and functions. 9 –11,29,30 Phenolic components obtained from the products of plants play an important role in the prevention of cancer. Epidemiological studies show that diets containing polyphenolic compounds are effective in decreasing cancer rates.…”

Section: Discussionmentioning

confidence: 99%

“…32,33 In the literature, there are articles reporting that the angiogenesis is decreased in the tumor groups as a result of factor VIII staining in studies with plants with antioxidant properties (Cornus mas L, curcumin, resveratrol, Viburnum opulus, quercetin). 8 –11,35 –37 Yang et al showed that AuNPs-Qu-5 inhibits angiogenesis and metastasis of quercetin in breast cancer cells tested by targeting the EGFR/ vascular endothelial growth factor receptor 2 (VEGFR-2) signal pathway. 5 In our study, the expression of FVIII in solid tumor masses was evaluated and the decrease in FVIII expression was found statistically significant in the groups given quercetin ( p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…7,8 Oxidative cell damage is known to be closely related to tumor formation, and the effects of various antioxidant plants (Viburnum opulus, curcumin, and Cornus mas L) on tumor formation have been reported in studies. 9 –11 In the literature, in various studies, quercetin was administered to mice at doses of 30, 40, 70, and 100 mg/kg. 12 –16 In this study, quercetin was investigated, which was tried in various types of cancer in different doses in Ehrlich ascites carcinoma (EAC) model.…”

Section: Introductionmentioning

confidence: 99%

“…The original of this tumor, which has a high transplantable rate, does not show regression and has a fast proliferation and a short survival time, leading to 100% death and does not have tumor-specific transplantation antigens in terms of immunology, and is also hyperdiploid. 9,10 Nucleolar organizer regions (NORs) are ribosomal gene regions on chromosomes. These regions consist of ribosomal DNA (rDNA) and proteins, and some of which have argyrophilic properties.…”

Section: Introductionmentioning

confidence: 99%

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Detection of antitumoral effects of quercetin through protein synthesis associated with argyrophilic nucleolar-regulating region

2020

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Quercetin is a natural flavonoid with potential anticancer properties without significant cytotoxicity in normal tissues. However, the effects of quercetin on Ehrlich ascites carcinoma (EAC) have not yet been clarified. The study aimed to show the antitumoral effect of quercetin through argyrophilic nucleolar organizer region (AgNOR) protein synthesis in mice carrying EAC. Thirty mice were used in the experiment (negative control ( n = 6), tumor control ( n = 8), quercetin 50 mg/kg ( n = 8), and quercetin 100 mg/kg ( n = 8) intravenously). The animals were euthanized on the 14th day, and the solid tumors were removed. Then, the total AgNOR area/nuclear area (TAA/NA) and average AgNOR number were calculated for each mice and the immunoreactivity of the factor VIII protein in tumor was evaluated. Tumor volumes and animal weights were statistically significant compared to the tumor control group ( p < 0.05). Statistically significant differences were observed between the groups in terms of TAA/NA ratio ( p < 0.05). Factor VIII expressions decreased in quercetin groups compared to control tumor tissue ( p < 0.05). The current study showed that quercetin has an important function against cancer development.

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Investigating the anti-tumoral effect of yarrow (Achillea milllefolium) on the mice in which ehrlich solid tumor is created

et al. 2022

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Examining the antitumoral effect of cornelian cherry (Cornus mas) in ehrlich ascites tumor-induced mice

Cited by 6 publications

References 0 publications

Acetone extracts of Berberis vulgaris and Cornus mas L. induce apoptosis in MCF-7 breast cancer cells

Acetone extracts of Berberis vulgaris and Cornus mas L. induce apoptosis in MCF-7 breast cancer cells

Detection of antitumoral effects of quercetin through protein synthesis associated with argyrophilic nucleolar-regulating region

Investigating the anti-tumoral effect of yarrow (Achillea milllefolium) on the mice in which ehrlich solid tumor is created

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