Examining the Association of Knee Pain With Modifiable Cardiometabolic Risk Factors

Charen, Daniel A; Zubizarreta, Nicole; Poeran, Jashvant; Colvin, Alicia

doi:10.1002/acr.24423

Cited by 11 publications

(4 citation statements)

References 56 publications

(57 reference statements)

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“…BMI was significantly greater in the PHFKP group but was not selected as a factor in the development of PHFKP in the logistic regression analysis. Overweight is a factor that increased the risk of knee pain in older adults 22 but did not seem to influence the development of PHFKP.…”

Section: Discussionmentioning

confidence: 90%

Predictors of post‐hip fracture knee pain in hospitalized older adults with intertrochanteric femoral fracture

Kaizu

Miyata

Arii

2022

PM&R

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Background: Post-hip fracture knee pain (PHFKP) is an important issue that contributes to reduced gait speed and prolonged hospitalization. Femoral morphology has been reported to contribute to the development of PHFKP, but an independent association has not been confirmed and clinically applicable cutoffs for predicting the development of PHFKP remain unclear. Objective: To determine whether femoral morphology and knee extension range of motion limitation are independent factors in PHFKP and to determine cutoffs for predicting the development of PHFKP. Design: Retrospective chart review study. Setting: Convalescent inpatient rehabilitation hospital. Participants: Patients in a convalescent ward after intertrochanteric femoral fracture surgery. Main Outcome Measures: PHFKP development, radiographic femoral morphology (leg length discrepancy and neck-shaft angle), and knee extension range of motion limitation. Results: PHFKP developed in 36 (35%) of the 103 patients enrolled. The PHFKP group had a longer hospital stay (p = .029), greater weight (p = .031), greater knee extension range of motion limitation (p = .001), and more varus neck-shaft angle (p < .001) compared to the non-PHFKP group. Varus neckshaft angle (odds ratio, 0.85; 95% confidence interval [CI], 0.78-0.92; p < .001) and knee extension range of motion limitation (odds ratio, 1.18; 95% CI, 1.07-1.30; p = .001) were significant factors for PHFKP development. Neck-shaft angle discrepancy and knee extension range of motion limitation demonstrated moderate accuracy in discriminating development of PHFKP according to receiver operating characteristic analysis, with cutoffs of 9.6 and 7.5 , respectively. Areas under the receiver operating characteristic curve were 0.77 (95% CI, 0.66-0.88; p < .001) for neck-shaft angle discrepancy and 0.67 (95% CI, 0.56-0.79; p = .004) for knee extension range of motion limitation. Conclusions: Varus neck-shaft angle and knee extension range of motion limitation were identified as independent predictors of PHFKP. The cutoff for neckshaft angle may be useful for predicting PHFKP development and to define an acceptable angle of fracture reduction to prevent PHFKP.

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Section: Discussionmentioning

confidence: 90%

Predictors of post‐hip fracture knee pain in hospitalized older adults with intertrochanteric femoral fracture

Kaizu

Miyata

Arii

2022

PM&R

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“…A further, and important aspect would be a more profound study of the influence of comorbidities, and other interesting players, such as oxidative stress [ 86 ]. More precise and organic studies on the interactions between anabolic/catabolic processes, diabetes, and degeneration of the cartilages would be much more useful than the sectorial or sporadic existing ones [ 87 , 88 , 89 ].…”

Section: Discussionmentioning

confidence: 99%

Osteoarthritis: New Insight on Its Pathophysiology

Coaccioli

Sarzi‐Puttini

Zis

et al. 2022

JCM

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Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements in recent years. It has been observed that cartilage degeneration is preceded by subchondral bone lesions, suggesting a key role of this mechanism within the pathogenesis and progression of OA, as well as the formation of ectopic bone and osteophytes. Moreover, low-grade, chronic inflammation of the synovial lining has gained a central role in the definition of OA physiopathology, and central immunological mechanisms, innate but also adaptive, are now considered crucial in driving inflammation and tissue destruction. In addition, the role of neuroinflammation and central sensitization mechanisms as underlying causes of pain chronicity has been characterized. This has led to a renewed definition of OA, which is now intended as a complex multifactorial joint pathology caused by inflammatory and metabolic factors underlying joint damage. Since this evidence can directly affect the definition of the correct therapeutic approach to OA, an improved understanding of these pathophysiological mechanisms is fundamental. To this aim, this review provides an overview of the most updated evidence on OA pathogenesis; it presents the most recent insights on the pathophysiology of OA, describing the interplay between immunological and biochemical mechanisms proposed to drive inflammation and tissue destruction, as well as central sensitization mechanisms. Moreover, although the therapeutic implications consequent to the renewed definition of OA are beyond this review scope, some suggestions for intervention have been addressed.

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“…Furthermore, this study did not include people with or at risk of knee OA. People with OA and DM are at a greater risk of metabolic syndromes and functional limitations such as higher pain and slower gait speed [ 21 , 24 , 31 , 32 , 33 , 34 , 35 ] requiring early intervention. Therefore, it is essential to examine the prognostic utility for gait speed in predicting incident DM, and its associated cutoff value.…”

Section: Introductionmentioning

confidence: 99%

Gait Speed as a Predictor for Diabetes Incidence in People with or at Risk of Knee Osteoarthritis: A Longitudinal Analysis from the Osteoarthritis Initiative

Alenazi

Alqahtani

Vennu

et al. 2021

IJERPH

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Background: This study examined the association between baseline gait speed with incident diabetes mellitus (DM) among people with or at elevated risk for knee OA. Materials and Methods: Participants from the Osteoarthritis Initiative, aged 45 to 79 years, where included. Participants with or at risk of knee OA from baseline to the 96-month visit were included. Participants with self-reported DM at baseline were excluded. DM incidence was followed over the 4-time points. Gait speed was measured at baseline using a 20-m walk test. Generalized estimating equations with logistic regression were utilized for analyses. Receiver operator characteristic curves and area under the curve were used to determine the cutoff score for baseline speed. Results: Of the 4313 participants included in the analyses (58.7% females), 301 participants had a cumulative incidence of DM of 7.0% during follow-up. Decreased gait speed was a significant predictor of incident DM (RR 0.44, p = 0.018). The threshold for baseline gait speed that predicted incident DM was 1.32 m/s with an area under the curve of 0.59 (p < 0.001). Conclusions: Baseline gait speed could be an important screening tool for identifying people at risk of incident diabetes, and the determined cutoff value for gait speed should be examined in future research.

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Examining the Association of Knee Pain With Modifiable Cardiometabolic Risk Factors

Cited by 11 publications

References 56 publications

Predictors of post‐hip fracture knee pain in hospitalized older adults with intertrochanteric femoral fracture

Predictors of post‐hip fracture knee pain in hospitalized older adults with intertrochanteric femoral fracture

Osteoarthritis: New Insight on Its Pathophysiology

Gait Speed as a Predictor for Diabetes Incidence in People with or at Risk of Knee Osteoarthritis: A Longitudinal Analysis from the Osteoarthritis Initiative

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