Examining the long-term effects of COVID-19 on the umbilical cord

Taş, Fatih; Yılmaz, Mehmet; ERDEMCİ, Fikri; Aşır, Fırat; Deveci, Engin

doi:10.32322/jhsm.1138691

Cited by 4 publications

(4 citation statements)

References 29 publications

(31 reference statements)

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“…patients. 18,19 The main mechanism determining mortality and morbidity in this disease is considered to be the activation of the innate immune system with cytokine storm. 18 TNF-α is involved in many acute inflammatory reactions and its expression is increased during inflammation.…”

Section: Discussionmentioning

confidence: 99%

Acute and long-term pathological effects of COVID-19 on the placenta during second trimester and labor.

Taş¹,

Erdemci̇²,

Yılmaz³

et al. 2023

Rev. Invest. Univ. Quindío

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Background: COVID-19 pandemic has affected all the world. The consequence of the COVID-19 infection causes many disorders in many organs, one of them is the placenta. COVID-19 disease has long-term effects on various tissues after recovery. The aim of this study was to investigate the placentas of pregnant women with healthy, COVID-19 positive during the second trimester and labor. Material and methods: A total of twenty-four pregnant women (8 patients per each group) were included in the study. Their placentas were processed for routine paraffin wax embedding protocol. The blood parameters of patients were recorded. Placental tissues were stained with hematoxylin-eosin dye and immune stained with TNF-α and ADAMTS-8. Statistical analysis was performed on blood and histological parameters. Results: AST and CRP values of biochemical parameters were higher in women with second trimester and labor groups than in the healthy group. Also, a significant increase in ALT values was observed in the labor group. Normal histology was observed in the placentas of healthy patients. More histopathology was recorded in the placentas of COVID-19 infected women compared to healthy placentas. The expression of TNF-α and ADAMTS-8 were found significantly higher in the COVID-19 placentas compared to the non-COVID-19 group. Conclusions: COVID-19 infection can cause pathological changes during pregnancy and labor. This study shows that COVID-19 not only acutely has adverse effects on placental pathologies but also has long-term effects. TNF-α and ADAMTS-8 primary antibodies can be a guide in demonstrating these effects.

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Section: Discussionmentioning

confidence: 99%

Acute and long-term pathological effects of COVID-19 on the placenta during second trimester and labor.

Taş¹,

Erdemci̇²,

Yılmaz³

et al. 2023

Rev. Invest. Univ. Quindío

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“…In the literature, there are studies showing histopathologic changes caused by COVID-19 infection on both placenta and umbilical cord [12][13] . Apart from covid-19 infection, diseases such as preeclampsia also cause histologic changes in the placenta 14 .…”

Section: Discussionmentioning

confidence: 99%

EGFR expression in COVID19 placentas

LİMANDAL,

AKKUŞ,

DEVECİ

et al. 2023

J. Drug Delivery Ther.

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Introduction: Coronavirus disease 2019 (COVID-19) pandemic is a global health problem that has claimed many lives worldwide. The disease is affecting almost all populations, but it poses a particular risk for groups such as the elderly and those with chronic diseases. Although the number of studies on clinical situations involving pregnant women and their infants infected with COVID-19 is increasing, the factors supporting the negative association between COVID-19 and pregnancy remain unclear. In this study, we aimed to examine the placental histopathologic structure using EGFR (Epidermal Growth Factor) antibody in placentas of COVID-19 pregnant patients. Materials and methods: In our study, placentas of a total of 40 pregnant women (regardless of age), including 20 pregnant women with C0VID-19 and 20 normotensive pregnant women, were used, and placentas were compared histopathologically and immunohistochemically. Results: In the hematoxylin and eosin stained sections of the control group placentas, tissue integrity was preserved and cellular structures were normal. In the placentas of Covid -19 group patients, it was observed that degenerations increased and cellular deformations developed. In sections of control group placentas, EGFR expression was negative in decidual cells and in areas with syncytial nodes. EGFR expression was positive in cytotrophoblast cells. In placenta sections of Covid-19 patients, EGFR expression was positive in vascular endothelium and Hofbauer cells. Conclusion: In our study, it was observed that EGFR expression, an important biomarker in tissue regeneration, was inhibited. We also concluded that Covid-19 caused degeneration and inflammation in placental tissue.

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“…In this study, it was found that especially intervillous thrombosis fibril accumulation was prominent in the basal plaque layer and the distribution of lesions related to the degree of invasive subgroups of structures containing large-scale lacunae was significant 10 . Like placenta previa, preeclampsia and covid-19 infection also cause histologic changes in the placenta and umblical cord [11][12][13] .…”

Section: Discussionmentioning

confidence: 99%

Histopatological Changes in Plasenta Previa, Plasenta Acreata and Normotensive Plasentas in the 3rd Trimestry of Pregnancy

ERDOĞAN,

DEVECİ,

PEKER

et al. 2023

J. Drug Delivery Ther.

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Introduction: One of the consequences of improper placentation is placenta previa, a condition in which the placenta is located on or near the internal cervical os. This condition is the major cause of bleeding in the last trimester of pregnancy. It is one of the causes of both maternal and perinatal morbidity and mortality. Placenta accreta is a disorder caused by abnormal invasion of the placental villi into the myometrium. In this study, we aimed to compare the histopathologic changes in placenta previa, placenta acreata and normotensive placentas during the third trimester of pregnancy. Materials and methods: In our study, placentas of a total of 60 pregnant women including 20 placenta previa, 20 placenta acreata and 20 normotensive pregnant women were used and the placentas were compared histopathologically. Results: In the control group placentas, the appearance of endothelial cells was normal, with a slight distribution of erythrocytes in the intervillous areas. Fibrinoid structures were observed to be smooth. Dysfunctional development of endothelial cells was observed in the sections of the placenta acreata group. Congestion and edema were observed in the vessels and degeneration was detected in the cells in the syncytial region. In placenta previa sections, muscle cells showed prominent pyknotic nucleus structures. Dilatations and fibronoid structures were seen in the vessels. Dense erythrocyte accumulation was detected in the intervillous areas. Conclusion: In our study, we concluded that placenta previa and placenta accreta cause very serious degenerations on the placentas. Keywords: Placenta, Placenta Previa, Plasenta Acreata, histopatology

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Examining the long-term effects of COVID-19 on the umbilical cord

Cited by 4 publications

References 29 publications

Acute and long-term pathological effects of COVID-19 on the placenta during second trimester and labor.

Acute and long-term pathological effects of COVID-19 on the placenta during second trimester and labor.

EGFR expression in COVID19 placentas

Histopatological Changes in Plasenta Previa, Plasenta Acreata and Normotensive Plasentas in the 3rd Trimestry of Pregnancy

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