Examining the Motor Phenotype of Patients with Both Essential Tremor and
                        Parkinson’s Disease

Simões, Rita Moiron; Constantino, Anne; Gibadullina, Eliza; Houghton, David; Louis, Elan D.; Litvan, Irene

doi:10.5334/tohm.89

Cited by 8 publications

(18 citation statements)

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“…In terms of the anatomical distribution of tremor, significantly fewer ET→PD than ET patients had widespread tremor or head tremor, which is in line with previous results. 4 Overall, the above observations suggest possible distinct tremor features in ET patients who are prone to developing PD.…”

Section: Discussionmentioning

confidence: 75%

“…Few previous studies have explored the clinical features of this combination. These studies have indicated the possible presence of several differences in MFs 2 – 4 , 8 , 11 and NMFs 12 , 13 between patients with isolated ET and their ET→PD counterparts.…”

Section: Discussionmentioning

confidence: 98%

“…This is in line with a previous study. 4 The interpretation is not clear, but could point to differences in involvement of the cerebellum in each patient subtype.…”

Section: Discussionmentioning

confidence: 99%

“… 1 Only a small number of studies have examined the prevalence and evolution of clinical features seen in patients with this particular clinical combination. 2 – 4 Moreover, most studies have focused on motor features (MFs) of ET→PD patients. 2 , 3 Given the fact that ET is no longer considered a monosymptomatic condition but, instead, a polysymptomatic disorder with both motor and non-motor elements, 5 , 6 we aimed to examine whether the ET→PD patients are distinct in terms of both MFs as well as non-motor features (NMFs).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Motor and Non-motor Features: Differences between Patients with Isolated Essential Tremor and Patients with Both Essential Tremor and Parkinson’s Disease

Ghika

Kyrozis

Potagas

et al. 2015

Tremor and Other Hyperkinetic Movements

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 98%

“…This is in line with a previous study. 4 The interpretation is not clear, but could point to differences in involvement of the cerebellum in each patient subtype.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Motor and Non-motor Features: Differences between Patients with Isolated Essential Tremor and Patients with Both Essential Tremor and Parkinson’s Disease

Ghika

Kyrozis

Potagas

et al. 2015

Tremor and Other Hyperkinetic Movements

View full text Add to dashboard Cite

“…The evidence ‘for’ a unidirectional relationship is derived from two main sources: (i) abundant anecdotal clinical observation and commentary ; (ii) cross‐sectional , case−control and prospective epidemiological studies .…”

Section: Evidence For a Unidirectional Relationshipmentioning

confidence: 99%

Is there a one‐way street from essential tremor to Parkinson's disease? Possible biological ramifications

Louis

Ottman

2013

Euro J of Neurology

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There is considerable evidence for an association between essential tremor (ET) and Parkinson’s disease (PD), although the topic remains somewhat controversial. An important issue, not previously addressed, is what seems to be the uni-directional nature of the relationship (ET→ET+PD and not PD→PD+ET). The aims of this review are (1) to discuss the evidence for and against a uni-directional relationship and (2) to discuss the implications of such a uni-directional relationship, if it exists, for disease mechanisms. Evidence “for” a uni-directional relationship includes: (1) abundant clinical anecdotal observation, (2) clinical and epidemiological studies. Evidence “against” is theoretic rather than empiric. Overall, the evidence “for” is stronger, though additional studies are needed in order to be certain; for the time being, it might be best to leave this as an open question. The biological ramifications/extensions of such a unidirectional relationship include: (1) that the association is causal (i.e., some aspect of ET pathophysiology predisposes an individual to develop PD), (2) that some ET cases may have a circumscribed form of Lewy body disease, and the secondary development of PD may represent a spread of those Lewy bodies in the brainstem. The presence and nature of the links between ET and PD are controversial. Further primary data (epidemiological and pathological) are needed to improve understanding of the relationship and its implications for the pathogenesis of both disorders.

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Memory Similarities Between Essential Tremor and Parkinson’s Disease: A Final Common Pathway?

Lafo

Jones

Okun

et al. 2015

The Clinical Neuropsychologist

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Objective-A growing body of literature supports the view that essential tremor (ET) involves alteration of cerebellar-thalamo-cortical networks which can result in working memory and executive deficits. In this study we tested the hypothesis that individuals with ET would exhibit worse performance on memory tasks requiring more intrinsic organization and structuring (i.e., word lists) relative to those with fewer 'executive' demands (i.e., stories), similar to that previously observed in individuals with Parkinson's disease (PD).Method-Participants included a convenience sample of 68 ET patients and 68 idiopathic PD patients, retrospectively matched based on age, education, and sex. All patients underwent routine neuropsychological evaluation assessing recent memory, auditory attention/working memory, language, and executive function. Memory measures included the Hopkins Verbal Learning Test-R and WMS-III Logical Memory.Results-Both ET and PD patients performed significantly worse on word list than story memory recall tasks. The magnitude of the difference between these two memory tasks was similar for ET and PD patients. In both patient groups, performance on measures of executive function and auditory attention/working memory was not distinctly correlated with word list vs. story recall.Conclusions-These findings suggest that frontal-executive dysfunction in both ET and PD may negatively influence performance on memory tests that are not inherently organized. Although the pathophysiology of these two 'movement disorders' are quite distinct, both have downstream effects on thalamo-frontal circuitry which may provide a common pathway for a similar memory phenotype. Findings are discussed in terms of neuroimaging evidence, conceptual models, and best practice.

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Examining the Motor Phenotype of Patients with Both Essential Tremor and Parkinson’s Disease

Cited by 8 publications

References 0 publications

Motor and Non-motor Features: Differences between Patients with Isolated Essential Tremor and Patients with Both Essential Tremor and Parkinson’s Disease

Motor and Non-motor Features: Differences between Patients with Isolated Essential Tremor and Patients with Both Essential Tremor and Parkinson’s Disease

Is there a one‐way street from essential tremor to Parkinson's disease? Possible biological ramifications

Memory Similarities Between Essential Tremor and Parkinson’s Disease: A Final Common Pathway?

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