Examining the relationship between diet-induced acidosis and cancer

Robey, Ian

doi:10.1186/1743-7075-9-72

Cited by 73 publications

(72 citation statements)

References 162 publications

(155 reference statements)

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“…There is some reporting on the palliative role of alkalinization through sodium bicarbonate treatment in cancer patients [36, 37], but most studies examining alkalinization in cancer treatment focus on animal models for breast and prostate cancer [15–19, 35, 38]. Although diet-induced, endogenous acid production is a relevant factor in chronic diseases [39–41] and may have a potential role in cancer [39, 42], it is not yet clear if dietary alkaline loading helps to prevent cancer or diminishes tumor aggression. …”

Section: Discussionmentioning

confidence: 99%

Investigating Mechanisms of Alkalinization for Reducing Primary Breast Tumor Invasion

Robey

Nesbit

2013

BioMed Research International

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The extracellular pH (pHe) of many solid tumors is acidic as a result of glycolytic metabolism and poor perfusion. Acidity promotes invasion and enhances metastatic potential. Tumor acidity can be buffered by systemic administration of an alkaline agent such as sodium bicarbonate. Tumor-bearing mice maintained on sodium bicarbonate drinking water exhibit fewer metastases and survive longer than untreated controls. We predict this effect is due to inhibition of tumor invasion. Reducing tumor invasion should result in fewer circulating tumor cells (CTCs). We report that bicarbonate-treated MDA-MB-231 tumor-bearing mice exhibited significantly lower numbers of CTCs than untreated mice (P < 0.01). Tumor pHe buffering may reduce optimal conditions for enzymes involved in tumor invasion such as cathepsins and matrix metalloproteases (MMPs). To address this, we tested the effect of transient alkalinization on cathepsin and MMP activity using enzyme activatable fluorescence agents in mice bearing MDA-MB-231 mammary xenografts. Transient alkalinization significantly reduced the fluorescent signal of protease-specific activatable agents in vivo (P ≤ 0.003). Alkalinization, however, did not affect expression of carbonic anhydrase IX (CAIX). The findings suggest a possible mechanism in a live model system for breast cancer where systemic alkalinization slows the rate of invasion.

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Section: Discussionmentioning

confidence: 99%

Investigating Mechanisms of Alkalinization for Reducing Primary Breast Tumor Invasion

Robey

Nesbit

2013

BioMed Research International

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“…Since MDPA is a glucocorticoids (cortisol) receptor agonist, then it may increase plasma cortisol and result in reduced calcium absorption and bone demineralization. Acidity enhances osteoblastic activity, increases osteoclastic activity and may also increase bone resorption by a direct, noncellular physicochemical process, Similarly acidogenic (high-protein) diets induce calciuria [16], However, the bicarbonate wasn't statistically different in cases compare with controls probably because of the diet of the participants or compensatory mechanism of the acid-base balance [17].…”

Section: Resultsmentioning

confidence: 84%

Serum Cortisol and the Risk of Osteoporosis in Nigerians on Medroxyprogesterone Acetate

Popoola¹,

Omotosho²,

Amenkhienan³

et al. 2016

Am. J. Biomed. Sci.

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Depo-Provera®; Depot-Medroxyprogesterone Acetate (DMPA) is one of the most used contraceptives and it is currently used by more than 30 million women in most of developed and developing countries. The study was designed to investigate the relationship between serum cortisol and the risk of osteoporosis in Nigerians using Depo-Provera®. We investigated 50 women using Depo-Provera® and 50 age-matched control, not on DPMA. Serum cortisol, progesterone, estrogen, estradiol, serum calcium, cathepsin K and urinary excretion rate of calcium were determined in subjects and controls. Serum cortisol and cathepsin K were significantly higher in women using DPMA Vs controls (P<0.01), we also found a significantly lower estradiol, serum calcium and an increased urinary excretion rate of calcium in subjects using DPMA as compared to controls (P<0.05). We found a positive correlation between serum cortisol and serum calcium (r=0.553) (P<0.01), serum cortisol and cathepsin K (r=0.568, P<0.05). Our study shows that hypercortisolaemia may be responsible for calcium loss, further investigation is needed to determine if cortisol induced calcium loss is responsible for bone demineralization associated with the use of DPMA.

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“…These stimulatory responses may have been caused by alterations in gastro-intestinal digestion, acid-base disequilibrium and tissue responses to metabolic hormones (5,21,27).…”

Section: Resultsmentioning

confidence: 99%

Growth rate and acid-base balance in turkeys fed a silage-containing diet modified by different dietary cation-anion difference

Gruszczyński¹,

Strobel

Wójcik

et al. 2017

Medycyna Weterynaryjna

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One of alternative foods for broiler turkeys might be inexpensive corn silage added to the typical formula. Although the addition of corn silage to the daily meal is well accepted by turkeys, the growth rate, according to our observations, is diminished. So far, very little attention has been paid to the manipulation of DCAD in growing turkeys. Since one of the causes of the growth rate suppression by silage may be a deviation in DCAD, we sought to determine whether lowering or increasing these values may improve the performance of growing young turkeys. It is known that in other species a higher DCAD stimulates the apparent digestibility coefficient (ADC) of protein and dry matter, but concomitantly the maintenance energy expenditure (MEm) is also higher (20,22). At least in some species, a lower acidic content and high potassium in the diet enhance both bone accretion and bone health. Seemingly, Kim et al. (14) discovered that, in opposition to chloride, cation supplementation alleviates the lysine-arginine antagonism in chicks.Hitherto, our attention in broilers has been focused on the specific effects of cations and anions in the diet (1, 13, 17, 23). Our aim was to determine the responses of turkeys to a corn silage diet with different values of DCAD and to draw attention to the possible usefulness of this kind of ingredient in turkey farming. Moreover, since the dietary intake has been shown to influence the acid-base balance (ABB), our studies were aimed at clarifying the response of ABB-parameters in turkeys fed a corn silage diet with different DCAD. To obtain Compared to the control group, the anion gap was insignificantly lower in birds exposed to the acidic diet, and was comparable to the decrease in HCO 3 -. Conversely, the addition of NaHCO 3 to the diet led to a marked elevation in HCO 3 -to 29.63 ± 0.4 mEq/L in group D and to 30.3 ± 0.69 mEq/l in group E. In conclusion, a change in DCAD during the feeding of forage containing CS exerts stimulatory effects on productive parameters of turkeys.

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Examining the relationship between diet-induced acidosis and cancer

Cited by 73 publications

References 162 publications

Investigating Mechanisms of Alkalinization for Reducing Primary Breast Tumor Invasion

Investigating Mechanisms of Alkalinization for Reducing Primary Breast Tumor Invasion

Serum Cortisol and the Risk of Osteoporosis in Nigerians on Medroxyprogesterone Acetate

Growth rate and acid-base balance in turkeys fed a silage-containing diet modified by different dietary cation-anion difference

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