Examining the response pressure along a fluid-filled elastic tube to comprehend Frank׳s arterial resonance model

Wang, Yuh Ying Lin; Sze, Wah-Keung; Lin, Chin Chih; Chen, Jiang Ming; Houng, Chin Chi; Chang, Chi Wei; Wang, Wei‐Kung

doi:10.1016/j.jbiomech.2015.02.026

Cited by 15 publications

(6 citation statements)

References 12 publications

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“…Thus, the variation of harmonics reveals variation of status of the arterial system, which has been proved a useful method in cardiovascular researches [18] . According to the observation of the previous researches, Lin Wang et al developed a PS wave model to simulate the low damped oscillation of arterial pressure wave [19] – [24] and to elaborate the meaning of the harmonic components in cardiovascular physiology [25] , [26] .…”

Section: Introductionmentioning

confidence: 99%

Development of a Standard Protocol for the Harmonic Analysis of Radial Pulse Wave and Assessing Its Reliability in Healthy Humans

Chang

Chen

Wang

2015

IEEE J. Transl. Eng. Health Med.

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This study was aimed to establish a standard protocol and to quantitatively assess the reliability of harmonic analysis of the radial pulse wave measured by a harmonic wave analyzer (TD01C system). Both intraobserver and interobserver assessments were conducted to investigate whether the values of harmonics are stable in successive measurements. An intraclass correlation coefficient (ICC) and a Bland–Altman plot were used for this purpose. For the reliability assessments of the intraobserver and the interobserver, 22 subjects (mean age 45 ± 14 years; 14 males and 8 females) were enrolled. The first eleven harmonics of the radial pulse wave presented excellent repeatability (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\text {ICCs}>0.9$ \end{document} and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\text {p}<0.001$ \end{document}) for the intraobserver assessment and high reproducibility (ICCs range from 0.83 to 0.96 and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\text {p}<0.001$ \end{document}) for the interobserver assessment. The Bland–Altman plot indicated that more than 90% of harmonic values fell within two standard deviations of the mean difference. Thus, we concluded that the harmonic analysis of the radial pulse wave using the TD01C system is a feasible and reliable method to assess a hemodynamic characteristic in clinical trial.

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Section: Introductionmentioning

confidence: 99%

Development of a Standard Protocol for the Harmonic Analysis of Radial Pulse Wave and Assessing Its Reliability in Healthy Humans

Chang

Chen

Wang

2015

IEEE J. Transl. Eng. Health Med.

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“…We propose that increasing C4CV may be a sign that the fundamental frequency of the arterial system does not match the heart rate. Contracting the heart at the fundamental frequency of the arterial system will preserve maximum energy in the ventricle‐arterial system (Wang et al ; Lin Wang et al , ) and achieve the highest efficiency of perfusion of the organs (Wang and Wang , , ). This way of working will reduce the burden on the heart and use the least power to maintain the blood supply to the body, which will manifest with the optimal harmonic amplitude and the smallest coefficient variations in these harmonics (Lin Wang et al ; Lin Wang and Wang ).…”

Section: Discussionmentioning

confidence: 99%

“…Contracting the heart at the fundamental frequency of the arterial system will preserve maximum energy in the ventricle‐arterial system (Wang et al ; Lin Wang et al , ) and achieve the highest efficiency of perfusion of the organs (Wang and Wang , , ). This way of working will reduce the burden on the heart and use the least power to maintain the blood supply to the body, which will manifest with the optimal harmonic amplitude and the smallest coefficient variations in these harmonics (Lin Wang et al ; Lin Wang and Wang ). However, the progression of aging atherosclerosis and cardiovascular disease will alter the perfusion status and elasticity of the macrovascular bed or microvascular bed, leading to deviations in specific frequency characteristics of the organs (Jan et al, ; Hsu et al ).…”

Section: Discussionmentioning

confidence: 99%

“…None of them directly measured the physical characteristics of the entire ventricle‐arterial system. Lin et al used a biomechanical model to explain why harmonic analysis of radial pulse waves is one of the complete methods for assessing the physical properties of the ventricular‐arterial system, and why these harmonic indicators of arterial pulse can reflect the function of the heart and organs (Lin Wang et al ; Wang and Wang ; Lin Wang ). Our previous study found that traditional cardiovascular risk factors have limitations in identifying patients with T2DM who is at high risk of heart disease, especially in those without angina symptoms or history of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

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Risk assessment of macrovascular and microvascular events in patients with type 2 diabetes by analyzing the amplitude variation of the fourth harmonic component of radial pulse wave

Liao

Chang²,

Wang³

et al. 2019

Physiol Rep

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This investigation explored the hypothesis that whether the coefficient of variation of the fourth harmonic amplitude of the radial pulse wave (C4CV) predicts the risk of macrovascular and microvascular events in patients with type 2 diabetes mellitus (T2DM). Radial pulse wave and brachial blood pressure were measured at baseline in 2324 patients with T2DM and C4CV was calculated using the Fourier series method. Macrovascular and microvascular events during follow‐up were determined by medical records. We plotted the Kaplan–Meier curve and performed a Cox proportional hazard model and a log‐rank test to estimate the effectiveness of C4CV as a risk predictor. We divided patients into quartile groups based on C4CV (<4.3%, 4.3% to 6.8%, 6.8% to 11.4%, and >11.4%). Compared with patients with C4CV < 4.3%, patients with C4CV> 11.4% had a double incidence of macrovascular events (hazard ratio, 2.13; 95% CI, 1.70–2.67) and microvascular events (hazard ratio, 2.08; 95% CI, 1.67–2.58), and the incidence of cardiovascular death was three times (hazard ratio, 3.03; 95% CI, 1.10–8.83). The Cox regression analysis demonstrated that the risk of both macrovascular and microvascular outcomes increases with the increase in quartile level of C4CV value (P < 0.0001). These associations remained after adjustment for age, gender, smoking, systolic blood pressure, diastolic blood pressure, dyslipidemia, diabetes duration, Hba1c, and cardiovascular disease (P < 0.0001). C4CV is a novel independent predictor of cardiovascular mortality, macrovascular events, and microvascular events in patients with T2DM.

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“…Furthermore, the cross-sectional study showed that the harmonics of the radial pulse spectrum were correlated with the ischemic heart disease [20] , [21] . To summarize results from those studies, the ventricular-arterial coupling system distributed the pressure pulse wave to different organs in proportions of harmonics according to the system state [16] , [22] . Therefore, the pattern of harmonic components could reveal the blood flow condition of organs [17] , [23] , and more specifically, reveal the condition of myocardial perfusion.…”

Section: Introductionmentioning

confidence: 99%

Radial Pulse Spectrum Analysis as Risk Markers to Improve the Risk Stratification of Silent Myocardial Ischemia in Type 2 Diabetic Patients

Chang

Liao

Chen

et al. 2018

IEEE J. Transl. Eng. Health Med.

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Diabetic patients with silent myocardial ischemia (SMI) have elevated rates of morbidity and mortality and need intensive care and monitoring. An early predictor of SMI may lead to early diagnosis and medical treatment to prevent progression and adverse clinical events. Therefore, this paper was aimed to evaluate the radial pulse spectrum as risk markers to improve the risk stratification of SMI in type-2 diabetic patients; 195 diabetic patients at high-risk of SMI were enrolled. All patients underwent myocardial perfusion imaging and radial pressure wave measurement. The spectrum analysis of the radial pressure wave was calculated and transformed into Fourier series coefficients Cns and Pns. The risk of SMI (odds ratio: 4.46, 95%, C.I. 1.61–12.4, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$P<0.01$ \end{document}) was raised in diabetic patients classified high-risk group by C2. Multivariable regression analysis showed that C2 (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$P<0.05$ \end{document}) and ankle–brachial index [(ABI) \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$P<0.05$ \end{document})] were related to SMI (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$R=0.46$ \end{document} and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$P<0.05$ \end{document}). The myocardial ischemic score (MIS), combining C2, C3, and P5, the albumin-to-creatinine ratio (ACR), and ABI, presented an excellent risk stratification performance in enrolled patients (odds ratio: 5.78, 95%, C.I. 2.29–14.6, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$P<0.01$ \end{document}). The area under receiver operating characteristic curves for C2, C3, P5, ABI, ACR, and MIS were 0.66, 0.60, 0.68, 0.51, 0.56, and 0.74, respectively, in identifying SMI. This paper demonstrated that C2 was independently associated with the extent of SMI in multivariable regression analysis. Odds ratio and chi-square tests reflected that C2 could b...

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Examining the response pressure along a fluid-filled elastic tube to comprehend Frank׳s arterial resonance model

Cited by 15 publications

References 12 publications

Development of a Standard Protocol for the Harmonic Analysis of Radial Pulse Wave and Assessing Its Reliability in Healthy Humans

Development of a Standard Protocol for the Harmonic Analysis of Radial Pulse Wave and Assessing Its Reliability in Healthy Humans

Risk assessment of macrovascular and microvascular events in patients with type 2 diabetes by analyzing the amplitude variation of the fourth harmonic component of radial pulse wave

Radial Pulse Spectrum Analysis as Risk Markers to Improve the Risk Stratification of Silent Myocardial Ischemia in Type 2 Diabetic Patients

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