Examining the role of neuroinflammation in major depression

Furtado, Melissa; Katzman, Martin A.

doi:10.1016/j.psychres.2015.06.009

Cited by 176 publications

(123 citation statements)

References 74 publications

(105 reference statements)

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“…Research over the past 20 years has shown that pro-inflammatory bodily states are associated with a propensity towards mental disorders such as depression and anxiety (Miller et al, 2009; Slavich and Irwin, 2014; Furtado and Katzman, 2015; Strawbridge et al, 2015) as well as an array of chronic medical illnesses (Aggarwal et al, 2006; Swardfager et al, 2010). Generally, decreases in inflammatory pathway activation during periods without active infection are associated with better physical and mental well-being (Elenkov et al, 2005); however, acute inflammatory responses are also adaptive, so the general decrease of pro-inflammatory (and increase in anti-inflammatory) immune mediators is not always a clear marker of health and wellness, and instead a healthy homeostatic balance between pro- and anti-inflammatory signaling is most adaptive (Black, 2002).…”

Section: Introductionmentioning

confidence: 99%

Yoga, Meditation and Mind-Body Health: Increased BDNF, Cortisol Awakening Response, and Altered Inflammatory Marker Expression after a 3-Month Yoga and Meditation Retreat

Cahn

Goodman

Peterson

et al. 2017

Front. Hum. Neurosci.

226

119

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Thirty-eight individuals (mean age: 34.8 years old) participating in a 3-month yoga and meditation retreat were assessed before and after the intervention for psychometric measures, brain derived neurotrophic factor (BDNF), circadian salivary cortisol levels, and pro- and anti-inflammatory cytokines. Participation in the retreat was found to be associated with decreases in self-reported anxiety and depression as well as increases in mindfulness. As hypothesized, increases in the plasma levels of BDNF and increases in the magnitude of the cortisol awakening response (CAR) were also observed. The normalized change in BDNF levels was inversely correlated with BSI-18 anxiety scores at both the pre-retreat (r = 0.40, p < 0.05) and post-retreat (r = 0.52, p < 0.005) such that those with greater anxiety scores tended to exhibit smaller pre- to post-retreat increases in plasma BDNF levels. In line with a hypothesized decrease in inflammatory processes resulting from the yoga and meditation practices, we found that the plasma level of the anti-inflammatory cytokine Interleukin-10 was increased and the pro-inflammatory cytokine Interleukin-12 was reduced after the retreat. Contrary to our initial hypotheses, plasma levels of other pro-inflammatory cytokines, including Interferon Gamma (IFN-γ), Tumor Necrosis Factor (TNF-α), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), and Interleukin-8 (IL-8) were increased after the retreat. Given evidence from previous studies of the positive effects of meditative practices on mental fitness, autonomic homeostasis and inflammatory status, we hypothesize that these findings are related to the meditative practices throughout the retreat; however, some of the observed changes may also be related to other aspects of the retreat such as physical exercise-related components of the yoga practice and diet. We hypothesize that the patterns of change observed here reflect mind-body integration and well-being. The increased BDNF levels observed is a potential mediator between meditative practices and brain health, the increased CAR is likely a reflection of increased dynamic physiological arousal, and the relationship of the dual enhancement of pro- and anti-inflammatory cytokine changes to healthy immunologic functioning is discussed.

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Section: Introductionmentioning

confidence: 99%

Yoga, Meditation and Mind-Body Health: Increased BDNF, Cortisol Awakening Response, and Altered Inflammatory Marker Expression after a 3-Month Yoga and Meditation Retreat

Cahn

Goodman

Peterson

et al. 2017

Front. Hum. Neurosci.

226

119

View full text Add to dashboard Cite

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“…For example, depression-related changes in the hypothalamic–pituitary–adrenal (HPA) axis and the immunological system may aggravate medical illnesses, leading to functional decline. (Furtado and Katzman 2015). Furthermore, depression is also associated with cognitive and brain changes, (Dotson, Resnick, and Zonderman 2008;Dotson, Szymkowics, Kirton, McLaren, Green, and Rohani 2014;Dotson, Zonderman, Davatzikos, Kraut, and Resnick 2009;Dotson, Zonderman, Kraut, and Resnick 2013) which are also known to impact functional abilities.…”

Section: Discussionmentioning

confidence: 99%

Successful aging: Advancing the science of physical independence in older adults

Anton

Woods

Ashizawa

et al. 2015

Ageing Research Reviews

215

162

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The concept of ‘Successful Aging’ has long intrigued the scientific community. Despite this long-standing interest, a consensus definition has proven to be a difficult task, due to the inherent challenge involved in defining such a complex, multi-dimensional phenomenon. The lack of a clear set of defining characteristics for the construct of successful aging has made comparison of findings across studies difficult and has limited advances in aging research. The domain in which consensus on markers of successful aging is furthest developed is the domain of physical functioning. For example, walking speed appears to be an excellent surrogate marker of overall health and predicts the maintenance of physical independence, a cornerstone of successful aging. The purpose of the present article is to provide an overview and discussion of specific health conditions, behavioral factors, and biological mechanisms that mark declining mobility and physical function and promising interventions to counter these effects. With life expectancy continuing to increase in the United States and developed countries throughout the world, there is an increasing public health focus on the maintenance of physical independence among all older adults.

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“…Neuropathic pain has a strong negative impact on everyday life activities and working performance and immensely reduces patients’ health related quality of life (Blyth et al, 2003). Neuro-immune interactions may be crucial for the development of neuropathic pain (Ellis and Bennett, 2013), and similar pathomechanisms have been implied for depression (Furtado and Katzman, 2015). Interactions between pro- and anti-inflammatory systems seem to play a major role (Üçeyler et al, 2009), which is underlined by data on disturbed pain behavior in animal models of cytokine or immune component deficiency (Cunha et al, 1999; Vale et al, 2003; Schoeniger-Skinner et al, 2007; Karam et al, 2011; Üçeyler et al, 2011; Sun et al, 2016).…”

Section: Introductionmentioning

confidence: 94%

Differential Impact of miR-21 on Pain and Associated Affective and Cognitive Behavior after Spared Nerve Injury in B7-H1 ko Mouse

Karl

Grießhammer

Üçeyler

et al. 2017

Front. Mol. Neurosci.

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MicroRNAs (miRNAs) are increasingly recognized as regulators of immune and neuronal gene expression and are potential master switches in neuropathic pain pathophysiology. miR-21 is a promising candidate that may link the immune and the pain system. To investigate the pathophysiological role of miR-21 in neuropathic pain, we assessed mice deficient of B7 homolog 1 (B7-H1), a major inhibitor of inflammatory responses. In previous studies, an upregulation of miR-21 had been shown in mouse lymphocytes. Young (8 weeks), middle-aged (6 months), and old (12 months) B7-H1 ko mice and wildtype littermates (WT) received a spared nerve injury (SNI). We assessed thermal withdrawal latencies and mechanical withdrawal thresholds. Further, we performed tests for anxiety-like and cognitive behavior. Quantitative real time PCR was used to determine miR-21 relative expression in peripheral nerves, and dorsal root ganglia (DRG) at distinct time points after SNI. We found mechanical hyposensitivity with increasing age of naïve B7-H1 ko mice. Young and middle-aged B7-H1 ko mice were more sensitive to mechanical stimuli compared to WT mice (young: p < 0.01, middle-aged: p < 0.05). Both genotypes developed mechanical and heat hypersensitivity (p < 0.05) after SNI, without intergroup differences. No relevant differences were found after SNI in three tests for anxiety like behavior in B7-H1 ko and WT mice. Also, SNI had no effect on cognition. B7-H1 ko and WT mice showed a higher miR-21 expression (p < 0.05) and invasion of macrophages and T cells in the injured nerve 7 days after SNI without intergroup differences. Our study reveals that increased miR-21 expression in peripheral nerves after SNI is associated with reduced mechanical and heat withdrawal thresholds. These results point to a role of miR-21 in the pathophysiology of neuropathic pain, while affective behavior and cognition seem to be spared. Contrary to expectations, B7-H1 ko mice did not show higher miR-21 expression than WT mice, thus, a B7-H1 knockout may be of limited relevance for the study of miR-21 related pain.

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Examining the role of neuroinflammation in major depression

Cited by 176 publications

References 74 publications

Yoga, Meditation and Mind-Body Health: Increased BDNF, Cortisol Awakening Response, and Altered Inflammatory Marker Expression after a 3-Month Yoga and Meditation Retreat

Yoga, Meditation and Mind-Body Health: Increased BDNF, Cortisol Awakening Response, and Altered Inflammatory Marker Expression after a 3-Month Yoga and Meditation Retreat

Successful aging: Advancing the science of physical independence in older adults

Differential Impact of miR-21 on Pain and Associated Affective and Cognitive Behavior after Spared Nerve Injury in B7-H1 ko Mouse

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