This study aimed to understand job characteristics of generations Y and Z who present a new workforce demographic challenge for organizations. Using the Work Design Questionnaire, data were collected from 582 representatives of these generations residing in Pakistan and Russia and analyzed using a latent profile analysis and a multinomial logistic regression. The analysis resulted in three profiles across both generations that point to weak, moderate, and strong preference for job characteristics. The results indicate generation Z have higher preferences for feedback from others and from the job than generation Y while generation Y have higher preferences for work conditions than generation Z. Specifically, we examine the effects of generation and work experience on the membership in job characteristics profiles. The results could assist organizations in re‐calibrating their work design approaches and practices to better integrate, motivate, and retain these cohorts of employees. Adjustments should be made to the attraction, recruitment, selection, and onboarding strategies for new employees and motivation, communication, and retention practices for current employees.